Development Level

Tbio 39 | 11,445
Tdark 4 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased mean corpuscular hem... 2 | 50
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased or absent threshold ... 1 | 101
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 25 | 11,493
osteosarcoma 25 | 7,950
ovarian cancer 23 | 8,520
psoriasis 15 | 6,694
medulloblastoma, large-cell 14 | 6,241
glioblastoma 13 | 5,792
adult high grade glioma 9 | 3,801
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
lung cancer 9 | 4,740
subependymal giant cell astrocytoma 9 | 2,287
astrocytoma 8 | 1,146
non-small cell lung cancer 8 | 2,890
tuberculosis 8 | 2,010
Cancer 6 | 2,499
Pick disease 6 | 1,894
invasive ductal carcinoma 6 | 2,951
malignant mesothelioma 6 | 3,232
primary pancreatic ductal adenocarcinoma 6 | 1,109
Astrocytoma, Pilocytic 5 | 3,081
Multiple myeloma 5 | 1,332
Oculocerebrorenal syndrome 5 | 29
primitive neuroectodermal tumor 5 | 3,035
Alzheimer's disease 4 | 658
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Neurodegenerative disease 4 | 414
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
dermatomyositis 4 | 966
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
spina bifida 4 | 1,074
Abdominal Pain 3 | 98
Cognitive delay 3 | 608
Dyspnea 3 | 76
Gaucher disease type 1 3 | 180
Glaucoma 3 | 239
Global developmental delay 3 | 608
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Mental and motor retardation 3 | 608
Neuropathy 3 | 261
Phenotypic variability 3 | 150
Renal Cell Carcinoma 3 | 214
Seizures 3 | 596
breast carcinoma 3 | 1,638
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
Abnormality of female internal genitalia 2 | 13
Adult onset 2 | 82
Autistic Disorder 2 | 364
Brain Diseases 2 | 24
COPD 2 | 118
Carcinoma, Squamous Cell 2 | 110
Cardiovascular system disease 2 | 246
Cataract 8 multiple types 2 | 33
Chemical and Drug Induced Liver Injury 2 | 195
Chest Pain 2 | 38
Congenital pes cavus 2 | 88
Cystic kidney 2 | 30
Deglutition Disorders 2 | 132
Distal amyotrophy 2 | 51
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Dysarthria 2 | 192
Fibromatosis, Gingival 2 | 8
Generalized muscle weakness 2 | 57
Hereditary gingival fibromatosis 2 | 8
Idiopathic gingival hyperplasia 2 | 8
Impaired cognition 2 | 96
Infantile onset 2 | 238
Lymphadenopathy 2 | 62
Mental impairment 2 | 95
Mood swings 2 | 77
Myoclonic Epilepsies, Progressive 2 | 44
Nerve Degeneration 2 | 121
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Paralysed 2 | 42
Precocious Puberty 2 | 28
Prominent back of the head 2 | 21
Prominent occiput 2 | 21
Renal cyst 2 | 30
Sebaceous adenoma 2 | 26
Skeletal muscle atrophy 2 | 139
Specific learning disability 2 | 47
Squamous cell carcinoma 2 | 129
Warburg micro syndrome 2 | 18
West Syndrome 2 | 28
hereditary spastic paraplegia 2 | 318
hypopigmented skin patch 2 | 59
muscle degeneration 2 | 139

Tissue

Blood and immune system 45 | 16,909
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Nervous System 44 | 16,725

Target Family

Non-IDG 26 | 12,091
Enzyme 18 | 4,145
Kinase 1 | 634

Reactome Pathway

TBC/RABGAPs 45 | 45
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
TBC1 domain family member 13 TBC1D13 Tdark Non-IDG -0.10266 1.34 92
TBC1 domain family member 2A TBC1D2 Tbio Non-IDG -1.28188 18.5 80
TBC1 domain family member 10A TBC1D10A Tbio Non-IDG -0.65759 0.00000 99
TBC1 domain family member 10B TBC1D10B Tbio Non-IDG 0.07 0.81 84
TBC1 domain family member 24 TBC1D24 Tbio Non-IDG -2.24696 145.0 34
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
Ras-related protein Rab-33A RAB33A Tbio Enzyme -0.82907 6.23 86
Ras-related protein Rab-35 RAB35 Tbio Enzyme -1.61645 42.9 224