Development Level

Tbio 7 | 10,625
Tchem 6 | 1,890
Tclin 2 | 602

IMPC Term

abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased heart rate 1 | 10
decreased mean platelet volume 1 | 12
decreased total body fat amoun... 1 | 186
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased lactate dehydrogenas... 1 | 3
persistence of hyaloid vascula... 1 | 22
shortened QRS complex duration 1 | 1

Disease

Cancer 8 | 2,346
Cholestasis 7 | 93
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
psoriasis 6 | 6,685
Prostatic Neoplasms 5 | 471
lung carcinoma 5 | 2,844
medulloblastoma, large-cell 5 | 6,234
osteosarcoma 5 | 7,933
Endometriosis 4 | 535
Intrahepatic cholestasis 4 | 19
aldosterone-producing adenoma 4 | 664
interstitial cystitis 4 | 2,299
invasive ductal carcinoma 4 | 2,950
lung cancer 4 | 4,466
non-small cell lung cancer 4 | 2,798
ovarian cancer 4 | 8,484
Atopic dermatitis 3 | 944
Cerebrotendinous xanthomatosis 3 | 12
Congenital bile acid synthesis defect 3 | 13
Disorders of Sex Development 3 | 5
Dysmenorrhea 3 | 19
Neoplasms, Hormone-Dependent 3 | 3
Neoplastic Cell Transformation 3 | 81
Obesity 3 | 616
Pain 3 | 70
Polycystic Ovary Syndrome 3 | 332
astrocytoma 3 | 1,493
atypical teratoid / rhabdoid tumor 3 | 4,369
glioblastoma 3 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
malignant mesothelioma 3 | 3,162
Atherosclerosis 2 | 275
Breast cancer 2 | 3,094
Carcinoma 2 | 2,147
Degenerative polyarthritis 2 | 93
Drug-Induced Liver Injury 2 | 118
Endometrial Neoplasms 2 | 50
Fatty liver disease 2 | 84
Hepatitis B 2 | 103
Leber congenital amaurosis 2 | 72
Liver carcinoma 2 | 217
Liver disease 2 | 219
Liver diseases 2 | 66
MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE 2 | 2
Mammary Neoplasms 2 | 410
Osteoarthritis 2 | 96
Patent ductus arteriosus 2 | 23
Peripheral Neuropathy 2 | 303
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,665
ductal carcinoma in situ 2 | 1,745
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
nephrosclerosis 2 | 329
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Acquired immunodeficiency syndrome 1 | 164
Adenocarcinoma 1 | 115
Ankylosing spondylitis 1 | 138
Bipolar Disorder 1 | 266
Calculus in biliary tract 1 | 2
Cataract 1 | 104
Cholelithiasis Prevention 1 | 1
Cholestasis of pregnancy 1 | 5
Chronic Lymphocytic Leukemia 1 | 242
Clubfoot 1 | 35
Common variable immunodeficiency 1 | 72
Extravasation of Diagnostic and Therapeutic Materials 1 | 6
Fatty Liver 1 | 48
Fragile X syndrome 1 | 31
Gaucher disease type 1 1 | 171
Gaucher disease type 3 1 | 76
Gout 1 | 93
Intestinal Neoplasms 1 | 11
Legg-Calve-Perthes Disease 1 | 8
Liver Cirrhosis 1 | 101
Liver neoplasms 1 | 109
Lung Neoplasms 1 | 171
Mammary Neoplasms, Experimental 1 | 150
Neoplasm Metastasis 1 | 138
Neurodegenerative disease 1 | 383
Neurogenic bowel 1 | 6
Oligohydramnios 1 | 18
Osteonecrosis 1 | 25
Osteoporosis 1 | 257
Primary cutaneous T-cell lymphoma 1 | 24
Sclerosing cholangitis 1 | 16
Septic arthritis 1 | 8
Stevens-Johnson syndrome 1 | 78
Thyroid Neoplasm 1 | 33
fascioscapulohumeral muscular dystrophy 1 | 100
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
hereditary spastic paraplegia 1 | 313
post-traumatic stress disorder 1 | 45

Tissue

Blood and immune system 15 | 17,995
Cardiovascular System 15 | 17,958
Digestive Tract 15 | 18,473
Endocrine System 15 | 18,512
Female tissues 15 | 18,647
Liver and Pancreas 15 | 18,136
Male tissues 15 | 17,969
Nervous System 15 | 18,561
Respiratory system 15 | 17,484
Skin and soft tissues 15 | 18,115
Urinary Tract 15 | 18,444

Target Family

Enzyme 11 | 4,146
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
Non-IDG 1 | 11,971

Reactome Pathway

Synthesis of bile acids and bi... 15 | 15
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.79404 68.6 142
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.48530 306.4 272
Aldo-keto reductase family 1 member C2 AKR1C2 Tchem Enzyme -2.61272 410.8 179
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.59796 38.3 100
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.65657 466.5 87
25-hydroxycholesterol 7-alpha-hydroxylase CYP7B1 Tbio Enzyme -1.63993 46.1 169
3 beta-hydroxysteroid dehydrogenase type 7 HSD3B7 Tbio Enzyme -1.08975 12.4 104
Aldo-keto reductase family 1 member C1 AKR1C1 Tchem Enzyme -3.05107 1183.3 130
Nuclear receptor coactivator 2 NCOA2 Tchem Non-IDG -2.13863 135.4 163
Prostacyclin synthase PTGIS Tbio Enzyme -2.49444 316.9 146