Development Level

Tbio 9 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

abnormal heart morphology 1 | 162
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 11 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Cholestasis 5 | 155
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
psoriasis 5 | 6,694
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Cancer 4 | 2,499
glioblastoma 4 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
Atopic dermatitis 3 | 952
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Intrahepatic cholestasis 3 | 20
alpha-methylacyl-CoA racemase deficiency 3 | 9
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
46,XY disorder of sex development due to testicular 17,20-desmolase deficiency 2 | 2
Alcoholic Intoxication, Chronic 2 | 289
BILIARY TRACT ABNORMALITY 2 | 16
Biliary Tract Diseases 2 | 16
Blood Coagulation Disorders 2 | 42
Cell Transformation, Neoplastic 2 | 97
Cerebrotendinous xanthomatosis 2 | 13
Congenital bile acid synthesis defect 2 | 15
Depressive disorder 2 | 409
Diarrhea 2 | 253
Disorders of Sex Development 2 | 5
Dysmenorrhea 2 | 21
Elevated hepatic transaminases 2 | 81
Endometriosis 2 | 540
Failure to gain weight 2 | 365
Hepatic enzyme increased 2 | 81
Hepatomegaly 2 | 285
Increased bilirubin level (finding) 2 | 18
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Experimental 2 | 769
Liver Dysfunction 2 | 99
Liver Failure 2 | 73
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE 2 | 2
Male Pseudohermaphroditism due to Deficiency of Testicular 17,20-Desmolase 2 | 2
Muscle Spasticity 2 | 195
Neonatal onset 2 | 21
Neoplasms, Hormone-Dependent 2 | 3
Neoplastic Cell Transformation 2 | 89
Neuropathy 2 | 261
Osteoarthritis 2 | 184
Pain 2 | 103
Patent ductus arteriosus 2 | 90
Pediatric failure to thrive 2 | 365
Peripheral Neuropathy 2 | 134
Peroxisomal disease 2 | 22
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
lung adenocarcinoma 2 | 2,716
nasopharyngeal carcinoma 2 | 1,058
nephrosclerosis 2 | 333
ovarian cancer 2 | 8,520
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
Abnormality of vision 1 | 40
Alkaline phosphatase serum increased 1 | 29
Ankylosing spondylitis 1 | 140
Common variable immunodeficiency 1 | 101
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Fibrosis 1 | 44
Intermittent migraine headaches 1 | 68
Male Pseudohermaphroditism 1 | 19
Migraine Disorders 1 | 76
Myoclonus 1 | 74
Neurogenic bowel 1 | 6
Pallor of optic disc 1 | 39
Renal Cell Carcinoma 1 | 214
Stevens-Johnson syndrome 1 | 92
Weight Gain 1 | 100
inflammatory breast cancer 1 | 286

Tissue

Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Blood and immune system 11 | 16,909
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Cardiovascular System 9 | 15,192

Target Family

Enzyme 11 | 4,145
Transporter 2 | 473

Reactome Pathway

Synthesis of bile acids and bi... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
Prostacyclin synthase PTGIS Tchem Enzyme -2.55019 341.8 152
3 beta-hydroxysteroid dehydrogenase type 7 HSD3B7 Tbio Enzyme -1.13969 12.9 112
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.73251 54.7 121
Sterol 26-hydroxylase, mitochondrial CYP27A1 Tchem Enzyme -2.99010 980.2 164
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.96016 6.61 126
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.87479 75.7 171
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.65191 40.5 121
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.47448 310.5 545