Development Level

Tbio 10 | 10,625
Tchem 4 | 1,890

IMPC Term

decreased circulating insulin ... 1 | 75
decreased heart rate 1 | 10
decreased mean platelet volume 1 | 12
improved glucose tolerance 1 | 56
persistence of hyaloid vascula... 1 | 22
shortened QRS complex duration 1 | 1

Disease

pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Cancer 5 | 2,346
lung cancer 5 | 4,466
non-small cell lung cancer 5 | 2,798
psoriasis 5 | 6,685
Cholestasis 4 | 93
glioblastoma 4 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
malignant mesothelioma 4 | 3,162
medulloblastoma, large-cell 4 | 6,234
osteosarcoma 4 | 7,933
pilocytic astrocytoma 4 | 3,086
Atopic dermatitis 3 | 944
Breast cancer 3 | 3,094
Congenital bile acid synthesis defect 3 | 13
Disorders of Sex Development 3 | 5
Dysmenorrhea 3 | 19
Endometriosis 3 | 535
Intrahepatic cholestasis 3 | 19
Neoplasms, Hormone-Dependent 3 | 3
Neoplastic Cell Transformation 3 | 81
Pain 3 | 70
Polycystic Ovary Syndrome 3 | 332
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
invasive ductal carcinoma 3 | 2,950
lung carcinoma 3 | 2,844
oligodendroglioma 3 | 2,849
ovarian cancer 3 | 8,484
pediatric high grade glioma 3 | 2,712
Cerebrotendinous xanthomatosis 2 | 12
Degenerative polyarthritis 2 | 93
Endometrial Neoplasms 2 | 50
Hepatitis B 2 | 103
MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE 2 | 2
Osteoarthritis 2 | 96
Patent ductus arteriosus 2 | 23
Peripheral Neuropathy 2 | 303
Prostatic Neoplasms 2 | 471
Schizophrenia 2 | 501
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,665
ductal carcinoma in situ 2 | 1,745
group 3 medulloblastoma 2 | 2,254
lung adenocarcinoma 2 | 2,713
nasopharyngeal carcinoma 2 | 1,056
nephrosclerosis 2 | 329
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
Adenoma 1 | 165
Adrenoleukodystrophy 1 | 31
Amyotrophic Lateral Sclerosis 1 | 431
Ankylosing spondylitis 1 | 138
Atherosclerosis 1 | 275
Atrophic vaginitis 1 | 14
Bipolar Disorder 1 | 266
Cataract 1 | 104
Clubfoot 1 | 35
Colorectal Neoplasms 1 | 217
Common variable immunodeficiency 1 | 72
Contraception 1 | 15
Drug-Induced Liver Injury 1 | 118
Dysfunctional uterine bleeding 1 | 9
Endometrial Hyperplasia Prevention 1 | 9
Endometrial carcinoma 1 | 18
Essential Hypertension 1 | 82
Gaucher disease type 3 1 | 76
Gout 1 | 93
Hypertension 1 | 287
Liver Cirrhosis 1 | 101
Liver Cirrhosis, Experimental 1 | 108
Liver carcinoma 1 | 217
Liver diseases 1 | 66
Lung Neoplasms 1 | 171
Malaria 1 | 140
Menopausal flushing 1 | 17
Neurogenic bowel 1 | 6
Osteonecrosis 1 | 25
Osteoporosis 1 | 257
Peroxisomal disease 1 | 20
Postmenopausal osteoporosis 1 | 19
Prostate cancer 1 | 172
Renal Cell Carcinoma 1 | 199
Schizoaffective disorder 1 | 33
Secondary malignant neoplasm of kidney 1 | 9
Secondary physiologic amenorrhea 1 | 9
Stevens-Johnson syndrome 1 | 78
Stomach Neoplasms 1 | 282
active Crohn's disease 1 | 918
atypical teratoid/rhabdoid tumor 1 | 1,095
fascioscapulohumeral muscular dystrophy 1 | 100
head and neck cancer 1 | 270
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
limb girdle muscular dystrophy 2A 1 | 156
non-small cell lung carcinoma 1 | 413
post-traumatic stress disorder 1 | 45

Tissue

Blood and immune system 14 | 17,995
Cardiovascular System 14 | 17,958
Digestive Tract 14 | 18,473
Endocrine System 14 | 18,512
Female tissues 14 | 18,647
Liver and Pancreas 14 | 18,136
Male tissues 14 | 17,969
Nervous System 14 | 18,561
Respiratory system 14 | 17,484
Skin and soft tissues 14 | 18,115
Urinary Tract 14 | 18,444

Target Family

Enzyme 12 | 4,146
Transporter 2 | 473

Reactome Pathway

Synthesis of bile acids and bi... 14 | 14
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.79404 68.6 142
Aldo-keto reductase family 1 member C2 AKR1C2 Tchem Enzyme -2.61272 410.8 179
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.59796 38.3 100
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.44034 296.1 443
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.19630 166.6 135
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.79562 66.0 151
Very long-chain acyl-CoA synthetase SLC27A2 Tbio Transporter -1.69835 51.8 98
3 beta-hydroxysteroid dehydrogenase type 7 HSD3B7 Tbio Enzyme -1.08975 12.4 104
Aldo-keto reductase family 1 member C1 AKR1C1 Tchem Enzyme -3.05107 1183.3 130