Development Level

Tbio 24 | 11,445
Tchem 7 | 1,598
Tclin 2 | 613

IMPC Phenotype

decreased total body fat amoun... 3 | 207
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
decreased mean corpuscular vol... 2 | 79
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 28 | 11,493
psoriasis 16 | 6,694
ovarian cancer 14 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
lung cancer 12 | 4,740
osteosarcoma 12 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
medulloblastoma, large-cell 11 | 6,241
Cholestasis 10 | 155
glioblastoma 10 | 5,792
Atopic dermatitis 8 | 952
Cancer 8 | 2,499
atypical teratoid / rhabdoid tumor 8 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
Astrocytoma, Pilocytic 7 | 3,081
Autosomal recessive predisposition 7 | 1,442
astrocytoma 7 | 1,146
interstitial cystitis 7 | 2,312
subependymal giant cell astrocytoma 7 | 2,287
Prostatic Neoplasms 6 | 495
adult high grade glioma 6 | 3,801
cystic fibrosis 6 | 1,696
ependymoma 6 | 4,679
non-small cell lung cancer 6 | 2,890
pituitary cancer 6 | 1,972
Breast cancer 5 | 3,578
Failure to gain weight 5 | 365
Intrahepatic cholestasis 5 | 20
Pediatric failure to thrive 5 | 365
aldosterone-producing adenoma 5 | 665
alpha-methylacyl-CoA racemase deficiency 5 | 9
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
oligodendroglioma 5 | 2,850
Elevated hepatic transaminases 4 | 81
Endometriosis 4 | 540
Hepatic enzyme increased 4 | 81
Hepatomegaly 4 | 285
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
Liver Dysfunction 4 | 99
Liver enzymes abnormal 4 | 81
Liver function test increased 4 | 81
Liver function tests abnormal finding 4 | 81
Polycystic ovary syndrome 4 | 360
Subclinical abnormal liver function tests 4 | 81
Transaminases increased 4 | 81
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
chronic rhinosinusitis 4 | 512
colon cancer 4 | 1,478
lung adenocarcinoma 4 | 2,716
nasopharyngeal carcinoma 4 | 1,058
pancreatic cancer 4 | 2,398
Adrenoleukodystrophy 3 | 29
BILIARY TRACT ABNORMALITY 3 | 16
Biliary Tract Diseases 3 | 16
Bipolar Disorder 3 | 666
Blood Coagulation Disorders 3 | 42
Cell Transformation, Neoplastic 3 | 97
Cerebrotendinous xanthomatosis 3 | 13
Diarrhea 3 | 253
Disorders of Sex Development 3 | 5
Dysmenorrhea 3 | 21
Fatty liver disease 3 | 103
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Liver Cirrhosis 3 | 181
Liver Failure 3 | 73
Liver diseases 3 | 87
Neonatal onset 3 | 21
Neoplasms, Hormone-Dependent 3 | 3
Neoplastic Cell Transformation 3 | 89
Neuropathy 3 | 261
Obesity 3 | 678
Osteoarthritis 3 | 184
Osteoporosis 3 | 363
Pain 3 | 103
Peripheral Neuropathy 3 | 134
Phenotypic variability 3 | 150
Simpson-Golabi-Behmel syndrome 3 | 19
Steatorrhea 3 | 34
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
dermatomyositis 3 | 966
nephrosclerosis 3 | 333
pediatric high grade glioma 3 | 1,064
ulcerative colitis 3 | 1,819
Atherosclerosis 2 | 291
Epilepsy 2 | 792
Seizures 2 | 596
breast carcinoma 2 | 1,638
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Liver and Pancreas 33 | 16,750
Skin and soft tissues 33 | 17,230
Female tissues 32 | 17,400
Male tissues 32 | 17,142
Urinary Tract 32 | 16,678
Blood and immune system 31 | 16,909
Respiratory system 29 | 16,393
Nervous System 28 | 16,725
Cardiovascular System 26 | 15,192

Target Family

Enzyme 18 | 4,145
Non-IDG 10 | 12,091
Nuclear Receptor 2 | 48
Transporter 2 | 473
Epigenetic 1 | 242

Reactome Pathway

Synthesis of bile acids and bi... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
Oxysterol-binding protein 1 OSBP Tbio Non-IDG -2.22394 167.6 160
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.17283 152.2 275
Oxysterol-binding protein-related protein 6 OSBPL6 Tbio Non-IDG -0.48139 2.36 100
Oxysterol-binding protein-related protein 7 OSBPL7 Tbio Non-IDG -0.33412 2.31 32
Oxysterol-binding protein-related protein 1 OSBPL1A Tbio Non-IDG -0.69214 5.13 145
Oxysterol-binding protein-related protein 9 OSBPL9 Tbio Non-IDG -0.70686 4.96 101
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.70498 494.6 94