Development Level

Tbio 27 | 10,625
Tchem 3 | 1,890

IMPC Term

preweaning lethality, complete... 3 | 633
increased NK cell number 2 | 19
increased or absent threshold ... 2 | 128
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal pelvic girdle bone mo... 1 | 11
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased Ly6C-positive mature... 1 | 4
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
increased CD11b-high dendritic... 1 | 5
increased CD4-positive, alpha ... 1 | 15
increased CD8-positive, alpha-... 1 | 11
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased circulating triglyce... 1 | 24
increased dendritic cell numbe... 1 | 2
increased fasted circulating g... 1 | 68
limb grasping 1 | 35
male infertility 1 | 62
short tibia 1 | 82
small liver 1 | 8

Disease

ovarian cancer 23 | 8,492
lung cancer 12 | 4,473
glioblastoma 11 | 5,572
medulloblastoma, large-cell 11 | 6,234
atypical teratoid / rhabdoid tumor 9 | 4,369
osteosarcoma 9 | 7,933
psoriasis 9 | 6,685
Multiple myeloma 8 | 1,328
astrocytic glioma 7 | 2,241
Cancer 6 | 2,346
Breast cancer 5 | 3,099
acute quadriplegic myopathy 5 | 1,157
adult high grade glioma 5 | 2,148
ependymoma 5 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
juvenile dermatomyositis 5 | 1,189
malignant mesothelioma 5 | 3,163
pancreatic cancer 5 | 2,300
primitive neuroectodermal tumor 5 | 3,031
Rheumatoid Arthritis 4 | 1,171
breast carcinoma 4 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
non-small cell lung cancer 4 | 2,798
oligodendroglioma 4 | 2,849
spina bifida 4 | 1,064
Atopic dermatitis 3 | 944
Intellectual disability 3 | 573
Liddle syndrome 3 | 14
active Crohn's disease 3 | 918
acute myeloid leukemia 3 | 785
adrenocortical carcinoma 3 | 1,427
astrocytoma 3 | 1,493
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
invasive ductal carcinoma 3 | 2,950
lung adenocarcinoma 3 | 2,714
pediatric high grade glioma 3 | 2,712
primary pancreatic ductal adenocarcinoma 3 | 1,271
progressive supranuclear palsy 3 | 674
Alzheimer's disease 2 | 644
Amyotrophic Lateral Sclerosis 2 | 432
Angelman syndrome 2 | 38
Carcinoma 2 | 2,147
Celiac disease 2 | 112
Endometriosis 2 | 535
Male infertility 2 | 170
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Parkinson's disease 2 | 364
Pick disease 2 | 1,893
Pick's disease 2 | 14
diabetes mellitus 2 | 1,663
ductal carcinoma in situ 2 | 1,745
limb girdle muscular dystrophy 2B 2 | 74
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pilocytic astrocytoma 2 | 3,086
posterior fossa group A ependymoma 2 | 1,511
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 686
Anemia 1 | 252
Arsenic Poisoning 1 | 59
Autistic Disorder 1 | 320
Bladder Neoplasm 1 | 109
Cardiovascular system disease 1 | 194
Cockayne syndrome 1 | 54
Coronary heart disease 1 | 59
Crohn Disease 1 | 97
Dermatologic disorders 1 | 65
Exophthalmos 1 | 16
Familial encephalopathy with neuroserpin inclusion bodies 1 | 8
Fanconi's anemia 1 | 50
Gaucher disease type 1 1 | 171
Gout 1 | 93
Head and neck squamous cell carcinoma 1 | 12
Hepatitis B 1 | 103
IGA Glomerulonephritis 1 | 454
Inflammatory Bowel Diseases 1 | 87
Juvenile arthritis 1 | 124
Kidney disease 1 | 397
Mammary Neoplasms 1 | 410
Muscular atrophy 1 | 67
Neoplasm Metastasis 1 | 138
Neurodegenerative disease 1 | 383
Peripheral vascular disease 1 | 90
Polycystic Ovary Syndrome 1 | 335
aldosterone-producing adenoma 1 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
fascioscapulohumeral muscular dystrophy 1 | 100
inflammatory breast cancer 1 | 404
nasopharyngeal carcinoma 1 | 1,056
pituitary cancer 1 | 1,972
sarcoidosis 1 | 368
sonic hedgehog group medulloblastoma 1 | 1,482
systemic lupus erythematosus 1 | 172
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 30 | 17,995
Cardiovascular System 30 | 17,958
Digestive Tract 30 | 18,473
Endocrine System 30 | 18,512
Female tissues 30 | 18,647
Liver and Pancreas 30 | 18,136
Male tissues 30 | 17,969
Nervous System 30 | 18,561
Respiratory system 30 | 17,484
Skin and soft tissues 30 | 18,115
Urinary Tract 30 | 18,444

Target Family

Non-IDG 25 | 11,969
Enzyme 5 | 4,146

Reactome Pathway

Synthesis of active ubiquitin:... 30 | 30
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 Q2 UBE2Q2 Tbio Non-IDG -0.88971 8.59 121
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Ubiquitin carboxyl-terminal hydrolase isozyme L3 UCHL3 Tchem Enzyme -2.08253 117.5 237
Ubiquitin-conjugating enzyme E2 D1 UBE2D1 Tbio Non-IDG -2.64320 417.6 171
Ubiquitin-conjugating enzyme E2 K UBE2K Tbio Non-IDG -2.25938 146.6 299
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.07855 124.6 194
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.20511 165.7 375
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.85028 69.5 187
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.49397 30.7 117