Development Level

Tbio 6 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal tooth morphology 1 | 24
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to t... 1 | 278
increased fasted circulating g... 1 | 76
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 6 | 11,493
ovarian cancer 6 | 8,520
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
tuberculosis 4 | 2,010
diabetes mellitus 3 | 1,728
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Byzanthine arch palate 2 | 194
Dysarthria 2 | 192
Exocrine pancreatic insufficiency 2 | 32
Hyperglycemia 2 | 137
Muscle hypotonia 2 | 571
Obesity 2 | 678
Pancreatic steatorrhea 2 | 6
Steatorrhea 2 | 34
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
subependymal giant cell astrocytoma 2 | 2,287
Abnormality of the immune system 1 | 18
Acquired scoliosis 1 | 281
Adenocarcinoma of lung 1 | 142
Arthrogryposis 1 | 54
Barrett's esophagus 1 | 182
Bell Palsy 1 | 58
Blepharoptosis 1 | 231
Cardiomyopathy, Dilated 1 | 83
Class III malocclusion 1 | 78
Conductive hearing loss 1 | 123
Congenital disorder of glycosylation 1 | 54
Congenital myasthenic syndrome 1 | 25
Curvature of spine 1 | 282
Deglutition Disorders 1 | 132
Desbuquois dysplasia 1 | 13
Disease Models, Animal 1 | 155
Easy fatigability 1 | 18
Essential Hypertension 1 | 94
Facial Paresis 1 | 59
Facial muscle weakness of muscles innervated by CN VII 1 | 58
Gowers sign 1 | 24
Gowers sign present 1 | 24
Highly variable severity 1 | 157
Hypertrophy of lower jaw 1 | 78
Hypesthesia 1 | 7
Immunologic Deficiency Syndromes 1 | 113
Impaired cognition 1 | 96
Increased size of mandible 1 | 78
Infantile onset 1 | 238
Liver Cirrhosis, Experimental 1 | 769
Lymphopenia 1 | 67
Mandibular hyperplasia 1 | 78
Mental impairment 1 | 95
Mildly increased creatine kinase 1 | 20
Motor delay 1 | 147
Muscle atrophy, proximal 1 | 11
Myasthenic Syndrome, Congenital, 4C, Associated With Acetylcholine Receptor Deficiency 1 | 5
Neck muscle weakness 1 | 17
Neoplasm Metastasis 1 | 168
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Neutrophil count decreased 1 | 47
No development of motor milestones 1 | 147
Parkinson's disease 1 | 392
Reactive airway disease 1 | 21
Recurrent respiratory infections 1 | 141
Reduced fetal movement 1 | 51
Sensorineural Hearing Loss (disorder) 1 | 284
Skeletal muscle atrophy 1 | 139
Strabismus 1 | 270
Tires quickly 1 | 18
Variable expressivity 1 | 157
Waddling gait 1 | 34
X-linked cerebral adrenoleukodystrophy 1 | 116
adrenocortical carcinoma 1 | 1,428
astrocytoma 1 | 1,146
cystic fibrosis 1 | 1,696
esophageal adenocarcinoma 1 | 737
hepatocellular carcinoma 1 | 547
lung adenocarcinoma 1 | 2,716
mandibular excess (physical finding) 1 | 78
muscle degeneration 1 | 139
pancreatic carcinoma 1 | 562
spina bifida 1 | 1,074
type II diabetes mellitus and post-ischemic heart failure 1 | 88

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 6 | 4,145
Kinase 1 | 634

Reactome Pathway

Synthesis of UDP-N-acetyl-gluc... 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.54336 33.7 87
UDP-N-acetylhexosamine pyrophosphorylase UAP1 Tbio Enzyme -2.32564 204.9 178
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 GFPT1 Tchem Enzyme -2.79406 584.2 135
Glucosamine 6-phosphate N-acetyltransferase GNPNAT1 Tbio Enzyme -1.45058 29.4 58
Phosphoacetylglucosamine mutase PGM3 Tbio Enzyme -2.21311 167.5 175
N-acetyl-D-glucosamine kinase NAGK Tbio Kinase -1.63894 41.9 210
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 Tbio Enzyme -2.69474 462.3 148