Development Level

Tbio 35 | 11,445
Tchem 13 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
abnormal sleep behavior 2 | 70
decreased circulating creatini... 2 | 39
embryonic growth retardation 2 | 106
persistence of hyaloid vascula... 2 | 33
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 50
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
tremors 1 | 39

Disease

Carcinoma 44 | 11,493
osteosarcoma 31 | 7,950
ovarian cancer 31 | 8,520
medulloblastoma, large-cell 28 | 6,241
ependymoma 22 | 4,679
glioblastoma 22 | 5,792
atypical teratoid / rhabdoid tumor 21 | 5,112
lung cancer 21 | 4,740
psoriasis 21 | 6,694
adult high grade glioma 16 | 3,801
oligodendroglioma 15 | 2,850
Breast cancer 14 | 3,578
astrocytic glioma 14 | 2,597
Kidney cancer 13 | 2,613
Astrocytoma, Pilocytic 12 | 3,081
invasive ductal carcinoma 12 | 2,951
Cancer 11 | 2,499
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung carcinoma 11 | 2,843
subependymal giant cell astrocytoma 11 | 2,287
group 3 medulloblastoma 10 | 4,104
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
ulcerative colitis 10 | 1,819
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
Autosomal recessive predisposition 8 | 1,442
Centronuclear myopathy 8 | 27
Pick disease 8 | 1,894
Schizophrenia 8 | 1,160
juvenile dermatomyositis 8 | 1,187
non-small cell lung cancer 8 | 2,890
Oculocerebrorenal syndrome 7 | 29
diabetes mellitus 7 | 1,728
tuberculosis 7 | 2,010
Acquired scoliosis 6 | 281
Curvature of spine 6 | 282
Epilepsy 6 | 792
Frontal bossing 6 | 157
Intellectual disability 6 | 1,016
Seizures 6 | 596
gastric carcinoma 6 | 807
spina bifida 6 | 1,074
Big calvaria 5 | 147
Cataract 5 | 297
DOID:2627 5 | 94
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
dermatomyositis 5 | 966
malignant mesothelioma 5 | 3,232
pancreatic carcinoma 5 | 562
primary Sjogren syndrome 5 | 735
Charcot-Marie-Tooth disease 4 | 62
Cognitive delay 4 | 608
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Diffuse large B-cell lymphoma 4 | 39
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Hydrocephalus 4 | 152
Hyperkyphosis 4 | 111
Kyphosis deformity of spine 4 | 114
Lens Opacities 4 | 231
Liver cancer 4 | 604
Low intelligence 4 | 645
Lymphoma, Large B-Cell, Diffuse 4 | 34
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
follicular lymphoma 4 | 20
medulloblastoma 4 | 720
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer's disease 3 | 658
Bipolar Disorder 3 | 666
Prostatic Neoplasms 3 | 495
Vascular disease 3 | 319
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962

Tissue

Blood and immune system 52 | 16,909
Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Cardiovascular System 51 | 15,192

Target Family

Enzyme 24 | 4,145
Kinase 16 | 634
Non-IDG 12 | 12,091

Reactome Pathway

Synthesis of PIPs at the plasm... 52 | 52
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Myotubularin-related protein 1 MTMR1 Tbio Enzyme -0.89579 6.93 82
Myotubularin-related protein 13 SBF2 Tbio Non-IDG -1.38747 24.7 15
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12941 13.9 47
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.47825 30.5 103
Synaptojanin-2 SYNJ2 Tbio Non-IDG -1.15573 16.3 157
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 INPPL1 Tchem Enzyme -2.05056 144.2 215
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.23001 181.6 129
Pleckstrin homology domain-containing family A member 4 PLEKHA4 Tbio Non-IDG 0.60 0.25 96