Development Level

Tbio 11 | 11,445
Tchem 3 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 1 | 220
decreased body weight 1 | 161
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
decreased heart weight 1 | 27
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased heart weight 1 | 62
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 14 | 11,493
ovarian cancer 11 | 8,520
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
Kidney cancer 7 | 2,613
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
astrocytic glioma 5 | 2,597
lung cancer 5 | 4,740
Centronuclear myopathy 4 | 27
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
psoriasis 4 | 6,694
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Neuropathy 3 | 261
Schizophrenia 3 | 1,160
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Acquired scoliosis 2 | 281
Bell Palsy 2 | 58
Bipolar Disorder 2 | 666
Cancer 2 | 2,499
Curvature of spine 2 | 282
Dental caries 2 | 164
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Myopathy 2 | 185
Neurodegenerative disease 2 | 414
Pick disease 2 | 1,894
Respiratory Failure 2 | 104
Yunis-Varon syndrome 2 | 6
aldosterone-producing adenoma 2 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Arachnodactyly 1 | 49
Big calvaria 1 | 147
Blepharoptosis 1 | 231
Charcot-Marie-Tooth disease 1 | 62
Chromosome 15q13.3 microdeletion syndrome 1 | 11
Congenital clubfoot 1 | 109
Congenital stationary night blindness 1 | 29
Contracture 1 | 96
Contracture of joint 1 | 93
Decreased liver function 1 | 24
Distal amyotrophy 1 | 51
Distal sensory impairment 1 | 52
Electromyogram abnormal 1 | 49
Exophthalmos 1 | 112
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Generalized muscle weakness 1 | 57
Hemangioma, Cavernous 1 | 20
Hypokinesia 1 | 19
Hypotonia, severe 1 | 33
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Leptospirosis 1 | 18
Liver disease 1 | 237
Liver dysfunction, mild 1 | 24
Long QT syndrome 1 1 | 20
Malignant hyperthermia 1 | 26
Mesothelioma, Malignant 1 | 105
Metabolic acidosis 1 | 90
Motor delay 1 | 147
Myocardial Infarction 1 | 151
Neck muscle weakness 1 | 17
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
No development of motor milestones 1 | 147
Pneumonia 1 | 174
Polyhydramnios 1 | 108
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Ptosis 1 | 48
Pyloric Stenosis 1 | 47
Reduced fetal movement 1 | 51
Skeletal muscle atrophy 1 | 139
Trichinosis 1 | 7
muscle degeneration 1 | 139
posterior fossa group A ependymoma 1 | 468
sarcoidosis 1 | 370

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 7 | 4,145
Kinase 5 | 634
Non-IDG 3 | 12,091

Reactome Pathway

Synthesis of PIPs at the early... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12941 13.9 47
Myotubularin-related protein 4 MTMR4 Tbio Enzyme -0.76288 7.50 138
Type II inositol 3,4-bisphosphate 4-phosphatase INPP4B Tbio Enzyme -1.55176 41.6 79
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha PIK3C2A Tchem Kinase -3.50398 3129.0 525
Phosphatidylinositol 4-kinase type 2-beta PI4K2B Tbio Enzyme -0.11208 1.83 135
Phosphatidylinositide phosphatase SAC2 INPP5F Tbio Enzyme -0.71120 5.56 89
Myotubularin MTM1 Tbio Enzyme -2.72507 527.3 235
Myotubularin-related protein 10 MTMR10 Tdark Non-IDG 0.10 0.58 25
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146