Development Level

Tbio 24 | 11,445
Tchem 12 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

cataract 3 | 92
decreased bone mineral content 3 | 151
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
decreased circulating aspartat... 2 | 34
decreased lactate dehydrogenas... 2 | 16
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
abnormal cranium morphology 1 | 36
abnormal maxilla morphology 1 | 17
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating iron lev... 1 | 30
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 22 | 11,493
ovarian cancer 18 | 8,520
psoriasis 18 | 6,694
osteosarcoma 17 | 7,950
medulloblastoma, large-cell 14 | 6,241
lung cancer 12 | 4,740
glioblastoma 11 | 5,792
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
atypical teratoid / rhabdoid tumor 9 | 5,112
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung carcinoma 8 | 2,843
Breast cancer 7 | 3,578
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
lung adenocarcinoma 5 | 2,716
Autosomal recessive predisposition 4 | 1,442
Barth syndrome 4 | 23
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
Toxic encephalopathy 4 | 141
active ulcerative colitis 4 | 764
malignant mesothelioma 4 | 3,232
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Acute pancreatitis 3 | 10
Amyotrophic lateral sclerosis 3 | 451
Arthritis 3 | 290
Atherosclerosis 3 | 291
Bipolar Disorder 3 | 666
Cancer 3 | 2,499
Coronary artery disease 3 | 268
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Paraplegia 3 | 74
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
spina bifida 3 | 1,074
Asphyxiating thoracic dystrophy 2 | 44
Atopic dermatitis 2 | 952
Cardiomegaly 2 | 116
Diabetes Mellitus, Experimental 2 | 108
Duchenne muscular dystrophy 2 | 601
Gas gangrene 2 | 17
Hepatomegaly 2 | 285
Hypertriglyceridemia result 2 | 37
IGA Glomerulonephritis 2 | 50
Lipodystrophy 2 | 40
MAJOR AFFECTIVE DISORDER 2 2 | 22
Melanoma 2 | 711
Membranous glomerulonephritis 2 | 13
Nephrotic Syndrome 2 | 78
Neurodegenerative disease 2 | 414
Polycystic ovary syndrome 2 | 360
Proteinuria 2 | 144
Sengers syndrome 2 | 18
Short stature 2 | 531
Steatohepatitis 2 | 44
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 665
familial hypertriglyceridemia 2 | 4
hereditary spastic paraplegia 2 | 318
juvenile dermatomyositis 2 | 1,187
primary Sjogren syndrome 2 | 735
Advanced bone age 1 | 35
Fatty Liver 1 | 70
Lupus nephritis 1 | 13
Sclerocystic Ovaries 1 | 17
Tall stature 1 | 34

Tissue

Blood and immune system 37 | 16,909
Digestive Tract 37 | 17,369
Female tissues 36 | 17,400
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Endocrine System 35 | 18,159
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 33 | 16,725
Respiratory system 32 | 16,393
Cardiovascular System 31 | 15,192

Target Family

Enzyme 35 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Synthesis of PA 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon AGPAT5 Tbio Enzyme -0.79526 4.42 180
Group IIE secretory phospholipase A2 PLA2G2E Tchem Enzyme -0.44734 2.04 30
Cytosolic phospholipase A2 delta PLA2G4D Tbio Enzyme -0.54284 3.41 45
Phospholipase A2, membrane associated PLA2G2A Tchem Enzyme -2.83666 743.3 137
Glycerol-3-phosphate acyltransferase 3 GPAT3 Tbio Enzyme -1.54939 32.0 138
Mitoguardin 1 MIGA1 Tbio Non-IDG -0.81790 6.81 22
Group IIF secretory phospholipase A2 PLA2G2F Tchem Enzyme -0.17609 1.39 2
Calcium-dependent phospholipase A2 PLA2G5 Tchem Enzyme -1.38065 26.2 137
Dihydroxyacetone phosphate acyltransferase GNPAT Tchem Enzyme -1.82166 68.1 178