Development Level

Tbio 5 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

increased mean corpuscular hem... 1 | 96

Disease

Carcinoma 6 | 11,493
psoriasis 5 | 6,694
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
atypical teratoid / rhabdoid tumor 3 | 5,112
colon cancer 3 | 1,478
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
lung adenocarcinoma 3 | 2,716
medulloblastoma, large-cell 3 | 6,241
ovarian cancer 3 | 8,520
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Autosomal recessive predisposition 2 | 1,442
Hypoglycemia 2 | 152
Liver Cirrhosis, Experimental 2 | 769
Pick disease 2 | 1,894
Seizures 2 | 596
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
beta-ketothiolase deficiency 2 | 13
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency 1 | 1
3-Methylcrotonyl-CoA carboxylase deficiency 1 | 11
3-methylglutaconic aciduria 1 | 29
Alpha-Methylacetoacetic Aciduria 1 | 1
Argininosuccinic aciduria 1 | 17
Astrocytoma, Pilocytic 1 | 3,081
Atopic dermatitis 1 | 952
Beta ketothiolase deficiency 1 | 1
Breast cancer 1 | 3,578
Carnitine deficiency 1 | 6
Chemical and Drug Induced Liver Injury 1 | 195
Chromosome 3q29 microdeletion syndrome 1 | 11
Chromosome 3q29 microduplication syndrome 1 | 6
Colonic Neoplasms 1 | 142
Comatose 1 | 56
Death in childhood 1 | 14
Deficiency of acetyl-CoA acetyltransferase 1 | 1
Dehydration 1 | 40
Dull intelligence 1 | 645
Epilepsy 1 | 792
Fever 1 | 138
Gaucher's disease 1 | 26
Glutaric aciduria 1 | 5
HMG CoA lyase deficiency 1 | 1
Hepatomegaly 1 | 285
Hydroxymethylglutaric aciduria 1 | 1
Hyperammonemia 1 | 30
Hyperargininemia 1 | 8
Intellectual disability 1 | 1,016
Isovaleric acidemia 1 | 15
Ketoacidosis, episodic 1 | 4
Kidney Failure, Chronic 1 | 46
Low intelligence 1 | 645
Maple syrup urine disease 1 | 24
Medium chain acyl-CoA dehydrogenase deficiency 1 | 13
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Metabolic acidosis 1 | 90
Methylmalonic acidemia 1 | 37
Mouth Neoplasms 1 | 55
Multiple carboxylase deficiency 1 | 7
Multiple myeloma 1 | 1,332
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Poor school performance 1 | 645
Propionic acidemia 1 | 16
Recurrence 1 | 33
Reye syndrome 1 | 11
Short chain acyl-CoA dehydrogenase deficiency 1 | 9
Somnolence 1 | 15
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
Vomiting 1 | 116
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
adrenocortical carcinoma 1 | 1,428
aldosterone-producing adenoma 1 | 665
astrocytic glioma 1 | 2,597
chronic rhinosinusitis 1 | 512
diabetes mellitus 1 | 1,728
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 559
gastric carcinoma 1 | 807
head and neck cancer 1 | 271
lung cancer 1 | 4,740
mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency 1 | 1
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
pancreatic cancer 1 | 2,398
pituitary cancer 1 | 1,972
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 7 | 4,145

Reactome Pathway

Synthesis of Ketone Bodies 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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