Development Level

Tbio 10 | 10,625
Tclin 1 | 602

IMPC Phenotype

decreased body length 1 | 108
decreased body weight 1 | 174
decreased lean body mass 1 | 195
increased CD4-positive, CD25-p... 1 | 18
increased body weight 1 | 42
persistence of hyaloid vascula... 1 | 22
preweaning lethality, complete... 1 | 633
tremors 1 | 34

Disease

ovarian cancer 8 | 8,491
medulloblastoma, large-cell 7 | 6,234
atypical teratoid / rhabdoid tumor 6 | 4,369
glioblastoma 6 | 5,572
osteosarcoma 6 | 7,933
lung cancer 5 | 4,473
pilocytic astrocytoma 5 | 3,086
Bipolar Disorder 4 | 266
Oculocerebrorenal syndrome 4 | 24
Pick disease 4 | 1,893
oligodendroglioma 4 | 2,849
primitive neuroectodermal tumor 4 | 3,031
Breast cancer 3 | 3,098
adult high grade glioma 3 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung adenocarcinoma 3 | 2,714
malignant mesothelioma 3 | 3,163
pediatric high grade glioma 3 | 2,712
sonic hedgehog group medulloblastoma 3 | 1,482
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Dent disease 2 | 20
Intellectual disability 2 | 573
Multiple myeloma 2 | 1,327
Schizophrenia 2 | 503
Whipple disease 2 | 5
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,670
ependymoma 2 | 2,514
group 4 medulloblastoma 2 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
psoriasis 2 | 6,685
spina bifida 2 | 1,064
Adenoid Cystic Carcinoma 1 | 99
Amyotrophic Lateral Sclerosis 1 | 432
Autistic Disorder 1 | 320
Bipolar affective disorder, current episode manic 1 | 13
Bipolar disorder in remission 1 | 19
Brain infarction 1 | 17
Calcinosis 1 | 63
Cancer 1 | 2,346
Candidiasis 1 | 48
Cataract 1 | 104
Cerebrovascular accident 1 | 44
Chronic intestinal vascular insufficiency 1 | 12
Ciliopathy 1 | 57
Down syndrome 1 | 548
Duchenne muscular dystrophy 1 | 602
Dysmenorrhea 1 | 19
Dystonia 1 | 77
Endometriosis 1 | 535
Febrile Convulsions 1 | 11
Fungal meningitis 1 | 7
Headache disorder 1 | 20
IGA Glomerulonephritis 1 | 454
Juvenile rheumatoid arthritis 1 | 105
Kidney disease 1 | 397
Loeys-Dietz syndrome 1 | 23
Muscle Weakness 1 | 92
Neurodegenerative disease 1 | 383
Osteoarthritis 1 | 96
Pain 1 | 70
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 334
Retinopathy of prematurity 1 | 21
Rheumatoid Arthritis 1 | 1,170
Rickets 1 | 42
Salivary Gland Neoplasms 1 | 45
Seizures 1 | 95
Sleeping sickness 1 | 37
Spinocerebellar ataxia type 2 1 | 19
active Crohn's disease 1 | 918
acute quadriplegic myopathy 1 | 1,157
aldosterone-producing adenoma 1 | 664
atypical teratoid/rhabdoid tumor 1 | 1,095
cutaneous lupus erythematosus 1 | 1,056
ductal carcinoma in situ 1 | 1,745
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 557
gastric carcinoma 1 | 832
head and neck cancer 1 | 270
hereditary spastic paraplegia 1 | 313
juvenile dermatomyositis 1 | 1,189
nephrosclerosis 1 | 329
primary pancreatic ductal adenocarcinoma 1 | 1,271
sarcoidosis 1 | 368
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 11 | 17,994
Cardiovascular System 11 | 17,957
Digestive Tract 11 | 18,472
Endocrine System 11 | 18,511
Female tissues 11 | 18,646
Liver and Pancreas 11 | 18,135
Male tissues 11 | 17,968
Nervous System 11 | 18,560
Respiratory system 11 | 17,483
Skin and soft tissues 11 | 18,114
Urinary Tract 11 | 18,443

Target Family

Enzyme 10 | 4,146
Non-IDG 1 | 11,969

Reactome Pathway

Synthesis of IP2, IP, and Ins ... 11 | 11
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.74048 58.0 91
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.17795 160.1 198
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.82701 66.8 118
Inositol-3-phosphate synthase 1 ISYNA1 Tbio Enzyme -2.37546 237.1 65
Inositol monophosphatase 1 IMPA1 Tclin Enzyme -2.31308 195.7 73
Type II inositol 3,4-bisphosphate 4-phosphatase INPP4B Tbio Enzyme -1.48298 36.7 47
Inositol monophosphatase 2 IMPA2 Tbio Enzyme -1.48299 31.4 60
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.23122 17.2 73
Type II inositol 1,4,5-trisphosphate 5-phosphatase INPP5B Tbio Enzyme -1.50642 28.4 85
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12186 13.2 40