Development Level

Tbio 10 | 10,625
Tclin 1 | 602

IMPC Term

decreased body length 1 | 108
decreased body weight 1 | 174
decreased lean body mass 1 | 195
increased CD4-positive, CD25-p... 1 | 18
increased body weight 1 | 42
persistence of hyaloid vascula... 1 | 22
preweaning lethality, complete... 1 | 633
tremors 1 | 34

Disease

ovarian cancer 8 | 8,492
medulloblastoma, large-cell 7 | 6,234
atypical teratoid / rhabdoid tumor 6 | 4,369
glioblastoma 6 | 5,572
osteosarcoma 6 | 7,933
lung cancer 5 | 4,473
pilocytic astrocytoma 5 | 3,086
Bipolar Disorder 4 | 266
Oculocerebrorenal syndrome 4 | 24
Pick disease 4 | 1,893
oligodendroglioma 4 | 2,849
primitive neuroectodermal tumor 4 | 3,031
Breast cancer 3 | 3,099
adult high grade glioma 3 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung adenocarcinoma 3 | 2,714
malignant mesothelioma 3 | 3,163
pediatric high grade glioma 3 | 2,712
sonic hedgehog group medulloblastoma 3 | 1,482
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
Dent disease 2 | 20
Intellectual disability 2 | 573
Multiple myeloma 2 | 1,328
Schizophrenia 2 | 503
Whipple disease 2 | 5
astrocytic glioma 2 | 2,241
astrocytoma 2 | 1,493
colon cancer 2 | 1,475
cystic fibrosis 2 | 1,670
ependymoma 2 | 2,514
group 4 medulloblastoma 2 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
pancreatic cancer 2 | 2,300
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
psoriasis 2 | 6,685
spina bifida 2 | 1,064
Adenoid Cystic Carcinoma 1 | 99
Amyotrophic Lateral Sclerosis 1 | 432
Autistic Disorder 1 | 320
Bipolar affective disorder, current episode manic 1 | 13
Bipolar disorder in remission 1 | 19
Brain infarction 1 | 17
Calcinosis 1 | 63
Cancer 1 | 2,346
Candidiasis 1 | 48
Cataract 1 | 104
Cerebrovascular accident 1 | 44
Chronic intestinal vascular insufficiency 1 | 12
Ciliopathy 1 | 57
Down syndrome 1 | 548
Duchenne muscular dystrophy 1 | 602
Dysmenorrhea 1 | 19
Dystonia 1 | 77
Endometriosis 1 | 535
Febrile Convulsions 1 | 11
Fungal meningitis 1 | 7
Headache disorder 1 | 20
IGA Glomerulonephritis 1 | 454
Juvenile rheumatoid arthritis 1 | 105
Kidney disease 1 | 397
Loeys-Dietz syndrome 1 | 23
Muscle Weakness 1 | 92
Neurodegenerative disease 1 | 383
Osteoarthritis 1 | 96
Pain 1 | 70
Parkinson's disease 1 | 364
Polycystic Ovary Syndrome 1 | 335
Retinopathy of prematurity 1 | 21
Rheumatoid Arthritis 1 | 1,171
Rickets 1 | 42
Salivary Gland Neoplasms 1 | 45
Seizures 1 | 95
Sleeping sickness 1 | 37
Spinocerebellar ataxia type 2 1 | 19
active Crohn's disease 1 | 918
acute quadriplegic myopathy 1 | 1,157
aldosterone-producing adenoma 1 | 664
atypical teratoid/rhabdoid tumor 1 | 1,095
cutaneous lupus erythematosus 1 | 1,056
ductal carcinoma in situ 1 | 1,745
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 557
gastric carcinoma 1 | 832
head and neck cancer 1 | 270
hereditary spastic paraplegia 1 | 313
juvenile dermatomyositis 1 | 1,189
nephrosclerosis 1 | 329
primary pancreatic ductal adenocarcinoma 1 | 1,271
sarcoidosis 1 | 368
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327
tuberculosis and treatment for 6 months 1 | 686
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 11 | 17,995
Cardiovascular System 11 | 17,958
Digestive Tract 11 | 18,473
Endocrine System 11 | 18,512
Female tissues 11 | 18,647
Liver and Pancreas 11 | 18,136
Male tissues 11 | 17,969
Nervous System 11 | 18,561
Respiratory system 11 | 17,484
Skin and soft tissues 11 | 18,115
Urinary Tract 11 | 18,444

Target Family

Enzyme 10 | 4,146
Non-IDG 1 | 11,969

Reactome Pathway

Synthesis of IP2, IP, and Ins ... 11 | 11
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12186 13.2 40
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.23122 17.2 73
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.17795 160.1 198
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.74048 58.0 91
Type II inositol 3,4-bisphosphate 4-phosphatase INPP4B Tbio Enzyme -1.48298 36.7 47
Inositol monophosphatase 2 IMPA2 Tbio Enzyme -1.48299 31.4 60
Type II inositol 1,4,5-trisphosphate 5-phosphatase INPP5B Tbio Enzyme -1.50642 28.4 85
Type I inositol 1,4,5-trisphosphate 5-phosphatase INPP5A Tbio Enzyme -1.28836 18.1 83
Inositol monophosphatase 1 IMPA1 Tclin Enzyme -2.31308 195.7 73
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.82701 66.8 118