Development Level

Tbio 12 | 11,651
Tdark 1 | 6,593

IMPC Phenotype

abnormal bone structure 1 | 187
decreased body length 1 | 101
decreased lean body mass 1 | 135
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
increased lymphocyte cell numb... 1 | 32
persistence of hyaloid vascula... 1 | 33
preweaning lethality, complete... 1 | 979
tremors 1 | 39

Disease

Carcinoma 9 | 11,493
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
ovarian cancer 8 | 8,520
ependymoma 7 | 4,679
Astrocytoma, Pilocytic 6 | 3,081
group 3 medulloblastoma 6 | 4,104
osteosarcoma 6 | 7,950
lung cancer 5 | 4,740
oligodendroglioma 5 | 2,850
Oculocerebrorenal syndrome 4 | 29
Pick disease 4 | 1,894
astrocytic glioma 4 | 2,597
primitive neuroectodermal tumor 4 | 3,035
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Intellectual disability 3 | 1,016
Whipple disease 3 | 6
colon cancer 3 | 1,478
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Curvature of spine 2 | 282
Dent disease 2 | 18
Depressive disorder 2 | 409
Dull intelligence 2 | 645
Epilepsy 2 | 792
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Seizures 2 | 596
cystic fibrosis 2 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
psoriasis 2 | 6,694
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
Abnormal urinary amino-acid findings 1 | 38
Amblyopia 1 | 38
Aminoaciduria 1 | 38
Anxiety 1 | 136
Anxiety disease 1 | 113
Calcinosis 1 | 70
Carcinoma, Squamous Cell 1 | 110
Childhood onset 1 | 38
Ciliopathy 1 | 71
Creutzfeldt-Jakob disease 1 | 21
Defective enamel matrix 1 | 35
Dehydration 1 | 40
Dental Enamel Hypoplasia 1 | 43
Dysplasia of tooth enamel 1 | 35
Enophthalmos 1 | 75
Febrile Convulsions 1 | 14
Fine hair 1 | 42
Hypercalciuria 1 | 27
Hyperkyphosis 1 | 111
Hypokalemia 1 | 52
Hypophonia 1 | 7
Knee joint valgus deformity 1 | 56
Kyphosis deformity of spine 1 | 114
Malignant neoplasm of skin 1 | 15
Muscle Rigidity 1 | 49
Obsessive compulsive behavior 1 | 25
Parkinsonian Disorders 1 | 56
Pathological fracture 1 | 20
Postural instability 1 | 19
Reduced visual acuity 1 | 63
Renal Tubular Acidosis, Type II 1 | 4
Renal glomerular disease 1 | 12
Resting Tremor 1 | 9
Salivary Gland Neoplasms 1 | 46
Serum cholesterol raised 1 | 22
Shuffling, short-stepped gait 1 | 5
Skin Neoplasms 1 | 69
Sparse scalp hair 1 | 42
Spinocerebellar ataxia type 2 1 | 23
Squamous cell carcinoma 1 | 129
Stereotyped Behavior 1 | 37
Stereotypic Movement Disorder 1 | 42
Sunken eyes 1 | 63
Thin dental enamel 1 | 35
Variant Creutzfeldt-Jakob disease 1 | 16
Voice Fatigue 1 | 7
Wrist swelling 1 | 2
X- linked recessive 1 | 110
obsessive-compulsive disorder 1 | 61

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Cardiovascular System 12 | 15,192

Target Family

Enzyme 11 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Synthesis of IP2, IP, and Ins ... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126
Myotubularin-related protein 9 MTMR9 Tbio Non-IDG -0.73836 6.81 80
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
Type II inositol 3,4-bisphosphate 4-phosphatase INPP4B Tbio Enzyme -1.55176 41.6 79
Inositol monophosphatase 2 IMPA2 Tbio Enzyme -1.49842 31.5 67
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12941 13.9 47
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.24647 18.1 100
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
Type II inositol 1,4,5-trisphosphate 5-phosphatase INPP5B Tbio Enzyme -1.53163 29.3 109
Inositol oxygenase MIOX Tbio Enzyme -1.73181 60.0 146