Development Level

Tbio 3 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
preweaning lethality, complete... 2 | 979
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal tail bud morphology 1 | 8
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278

Disease

Breast cancer 3 | 3,578
Congenital disorder of glycosylation 3 | 54
ovarian cancer 3 | 8,520
Abnormal isoelectric focusing of serum transferrin 1 | 3
Autosomal recessive non-syndromic intellectual disability 1 | 7
Autosomal recessive predisposition 1 | 1,442
Batten disease 1 | 13
Blood Coagulation Disorders 1 | 42
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iaa 1 | 1
Carcinoma 1 | 11,493
Cardiomyopathy, Dilated 1 | 83
Cataract 1 | 297
Cerebellar Ataxia 1 | 304
Cerebral atrophy 1 | 178
Citrullinemia 1 | 14
Coagulation abnormalities 1 | 27
Coloboma 1 | 51
Coloboma, Ocular, And Ichthyosis, Brain Malformations, And Endocrine Abnormalities 1 | 1
Congenital Disorder Of Glycosylation, Type Im 1 | 1
Congenital Disorder of Glycosylation, Type Iq 1 | 1
Creutzfeldt-Jakob Syndrome 1 | 10
Creutzfeldt-Jakob disease 1 | 21
DK1-CDG 1 | 1
Death in early childhood 1 | 82
Death in infancy 1 | 82
Disseminated superficial actinic porokeratosis 1 | 4
Dry skin 1 | 75
Endometriosis 1 | 540
Epilepsy 1 | 792
Failure to gain weight 1 | 365
Familial isolated dilated cardiomyopathy 1 | 41
Fukuyama congenital muscular dystrophy 1 | 8
Glaucoma 1 | 239
Hemorrhagic Disorders 1 | 30
Hepatomegaly 1 | 285
Hypoketotic hypoglycemia 1 | 11
Hypsarrhythmia 1 | 25
Ichthyoses 1 | 41
Impaired cognition 1 | 96
Intellectual disability 1 | 1,016
Kahrizi syndrome 1 | 1
LEFT VENTRICULAR NONCOMPACTION 10 1 | 40
LEFT VENTRICULAR NONCOMPACTION 8 1 | 40
Lipoatrophy 1 | 19
Melanoma 1 | 711
Mental impairment 1 | 95
Mitral valve insufficiency 1 | 49
Myalgia 1 | 54
Nipples absent or rudimentary 1 | 3
Otitis Media 1 | 52
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
Pediatric failure to thrive 1 | 365
Porokeratosis of Mibelli 1 | 4
Porokeratosis, Disseminated Superficial Actinic 1 | 4
Postnatal microcephaly 1 | 24
Seizures 1 | 596
Sparse eyebrow 1 | 42
Sparse eyelashes 1 | 31
Splenomegaly 1 | 190
Transsexualism 1 | 4
Waterhouse-Friderichsen syndrome 1 | 11
Xerosis 1 | 75
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute myeloid leukemia 1 | 783
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
breast carcinoma 1 | 1,638
chronic rhinosinusitis 1 | 512
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 4,679
glioblastoma 1 | 5,792
group 4 medulloblastoma 1 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
malignant mesothelioma 1 | 3,232
medulloblastoma, large-cell 1 | 6,241
nasopharyngeal carcinoma 1 | 1,058
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic cancer 1 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
psoriasis 1 | 6,694
tuberculosis 1 | 2,010

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

Reactome Pathway

Synthesis of Dolichyl-phosphat... 5 | 5
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dolichol kinase DOLK Tbio Enzyme -1.89047 77.2 58
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Polyprenol reductase SRD5A3 Tbio Enzyme -1.38816 25.5 72
Dolichyldiphosphatase 1 DOLPP1 Tdark Enzyme 0.30 0.50 60
Dehydrodolichyl diphosphate synthase complex subunit NUS1 NUS1 Tbio Enzyme -1.37569 28.5 55