Development Level

Tbio 65 | 10,625
Tchem 23 | 1,890
Tclin 8 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 12 | 633
embryonic lethality prior to o... 4 | 148
prenatal lethality prior to he... 2 | 64
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal pharyngeal arch morph... 1 | 2
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating insulin ... 1 | 75
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
polydactyly 1 | 22
small testis 1 | 37

Disease

ovarian cancer 69 | 8,484
psoriasis 53 | 6,685
lung cancer 51 | 4,466
osteosarcoma 45 | 7,933
malignant mesothelioma 40 | 3,162
medulloblastoma, large-cell 40 | 6,234
glioblastoma 39 | 5,572
non-small cell lung cancer 37 | 2,798
Multiple myeloma 31 | 1,327
group 3 medulloblastoma 31 | 2,254
primitive neuroectodermal tumor 28 | 3,031
Breast cancer 25 | 3,094
Cancer 24 | 2,346
adrenocortical carcinoma 23 | 1,427
atypical teratoid / rhabdoid tumor 22 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
pediatric high grade glioma 22 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
lung adenocarcinoma 20 | 2,713
Waldenstrons macroglobulinemia 17 | 765
invasive ductal carcinoma 17 | 2,950
HIV Infections 16 | 100
nasopharyngeal carcinoma 15 | 1,056
dermatomyositis 14 | 933
oligodendroglioma 14 | 2,849
posterior fossa group A ependymoma 14 | 1,511
colon cancer 13 | 1,475
ductal carcinoma in situ 12 | 1,745
Endometriosis 11 | 535
astrocytoma 11 | 1,493
atypical teratoid/rhabdoid tumor 9 | 1,095
primary Sjogren syndrome 9 | 789
Seckel syndrome 8 | 34
astrocytic glioma 8 | 2,241
diabetes mellitus 8 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Meier-Gorlin syndrome 7 | 12
juvenile dermatomyositis 7 | 1,189
non primary Sjogren syndrome sicca 7 | 840
pancreatic cancer 7 | 2,300
pilocytic astrocytoma 7 | 3,086
pituitary cancer 7 | 1,972
sonic hedgehog group medulloblastoma 7 | 1,482
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 1,557
Atopic dermatitis 6 | 944
IGA Glomerulonephritis 6 | 454
acute myeloid leukemia 6 | 780
breast carcinoma 6 | 1,614
ependymoma 6 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung carcinoma 6 | 2,844
medulloblastoma 6 | 1,524
ulcerative colitis 6 | 2,087
Carcinoma 5 | 2,147
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Mantle cell lymphoma 5 | 18
Pick disease 5 | 1,893
adult high grade glioma 5 | 2,148
primary pancreatic ductal adenocarcinoma 5 | 1,271
Bladder Neoplasm 4 | 109
Colonic Neoplasms 4 | 126
Colorectal Neoplasms 4 | 217
Peripheral Neuropathy 4 | 303
Squamous cell carcinoma of esophagus 4 | 82
active Crohn's disease 4 | 918
acute quadriplegic myopathy 4 | 1,157
esophageal adenocarcinoma 4 | 737
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 16
Acute promyelocytic leukemia, FAB M3 3 | 10
Adenocarcinoma of pancreas 3 | 12
Adenoma 3 | 165
Alzheimer's disease 3 | 644
Animal Mammary Neoplasms 3 | 136
Ataxia telangiectasia 3 | 31
Cockayne syndrome 3 | 54
Liver carcinoma 3 | 217
Lung Neoplasms 3 | 171
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Mammary Neoplasms, Experimental 3 | 150
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
Microcephaly 3 | 149
Xeroderma pigmentosum 3 | 41
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,665
gastric cancer 3 | 430
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
inflammatory breast cancer 3 | 404
interstitial cystitis 3 | 2,299
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Duchenne muscular dystrophy 2 | 602
Polycystic Ovary Syndrome 2 | 332
Stomach Neoplasms 2 | 282
hepatocellular carcinoma 2 | 532
non-small cell lung carcinoma 2 | 413

Tissue

Blood and immune system 99 | 17,995
Digestive Tract 99 | 18,473
Endocrine System 99 | 18,512
Female tissues 99 | 18,647
Liver and Pancreas 99 | 18,136
Male tissues 99 | 17,969
Nervous System 99 | 18,561
Urinary Tract 99 | 18,444
Cardiovascular System 98 | 17,958
Respiratory system 98 | 17,484
Skin and soft tissues 98 | 18,115

Target Family

Enzyme 57 | 4,146
Non-IDG 41 | 11,971
Kinase 1 | 634

Reactome Pathway

Synthesis of DNA 99 | 99
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177