Development Level

Tbio 96 | 11,445
Tchem 9 | 1,598
Tclin 8 | 613
Tdark 6 | 6,588

IMPC Phenotype

preweaning lethality, complete... 19 | 979
embryonic lethality prior to o... 8 | 239
abnormal embryo size 6 | 220
embryonic growth retardation 5 | 106
embryonic lethality prior to t... 5 | 278
increased mean corpuscular vol... 3 | 92
abnormal heart morphology 2 | 162
abnormal placenta size 2 | 20
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased mean corpuscular hem... 2 | 31
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal placenta morphology 1 | 5
abnormal skin coloration 1 | 25
brachydactyly 1 | 19
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
female infertility 1 | 60
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
syndactyly 1 | 23

Disease

ovarian cancer 82 | 8,520
psoriasis 59 | 6,694
lung cancer 57 | 4,740
Carcinoma 55 | 11,493
osteosarcoma 52 | 7,950
glioblastoma 46 | 5,792
group 3 medulloblastoma 45 | 4,104
medulloblastoma, large-cell 45 | 6,241
non-small cell lung cancer 43 | 2,890
malignant mesothelioma 42 | 3,232
atypical teratoid / rhabdoid tumor 33 | 5,112
Multiple myeloma 32 | 1,332
Breast cancer 31 | 3,578
Cancer 30 | 2,499
primitive neuroectodermal tumor 30 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
adrenocortical carcinoma 28 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
lung adenocarcinoma 24 | 2,716
adult high grade glioma 21 | 3,801
ependymoma 20 | 4,679
invasive ductal carcinoma 20 | 2,951
Waldenstrons macroglobulinemia 19 | 765
nasopharyngeal carcinoma 17 | 1,058
HIV Infections 15 | 102
colon cancer 15 | 1,478
dermatomyositis 14 | 966
oligodendroglioma 14 | 2,850
ductal carcinoma in situ 13 | 1,745
Endometriosis 12 | 540
astrocytoma 12 | 1,146
diabetes mellitus 11 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Autosomal recessive predisposition 10 | 1,442
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
Pick disease 9 | 1,894
astrocytic glioma 9 | 2,597
Astrocytoma, Pilocytic 8 | 3,081
Atopic dermatitis 8 | 952
Kidney cancer 8 | 2,613
Seckel syndrome 8 | 34
acute myeloid leukemia 8 | 783
breast carcinoma 8 | 1,638
pancreatic cancer 8 | 2,398
primary Sjogren syndrome 8 | 735
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Meier-Gorlin syndrome 7 | 10
Micrognathism 7 | 275
Small head 7 | 374
active Crohn's disease 7 | 922
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 7
Intellectual disability 6 | 1,016
esophageal adenocarcinoma 6 | 737
juvenile dermatomyositis 6 | 1,187
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Cryptorchidism 5 | 296
Failure to gain weight 5 | 365
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Isolated growth hormone deficiency 5 | 30
Liver Cirrhosis, Experimental 5 | 769
Mantle cell lymphoma 5 | 23
Osteoporosis 5 | 363
Pediatric failure to thrive 5 | 365
acute quadriplegic myopathy 5 | 1,158
medulloblastoma 5 | 720
primary pancreatic ductal adenocarcinoma 5 | 1,109
Birth length less than 3rd percentile 4 | 6
Cockayne syndrome 4 | 60
Cognitive delay 4 | 608
Colorectal Neoplasms 4 | 243
Congenital small ears 4 | 48
Delayed bone age 4 | 136
Dull intelligence 4 | 645
Full lower lip 4 | 64
Global developmental delay 4 | 608
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Microstomia 4 | 78
Poor school performance 4 | 645
Prominent lower lip 4 | 64
Short stature 4 | 531
Slender, gracile long tubular bones 4 | 21
Xeroderma pigmentosum 4 | 43
cutaneous lupus erythematosus 4 | 1,057
group 4 medulloblastoma 4 | 1,855
progressive supranuclear palsy 4 | 676
Alzheimer's disease 3 | 658
gastric carcinoma 3 | 807
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 118 | 18,159
Blood and immune system 117 | 16,909
Digestive Tract 117 | 17,369
Female tissues 117 | 17,400
Male tissues 117 | 17,142
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Urinary Tract 117 | 16,678
Cardiovascular System 116 | 15,192
Liver and Pancreas 116 | 16,750
Skin and soft tissues 116 | 17,230

Target Family

Enzyme 67 | 4,145
Non-IDG 51 | 12,091
Kinase 1 | 634

Reactome Pathway

Synthesis of DNA 119 | 119
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
DNA replication complex GINS protein SLD5 GINS4 Tbio Non-IDG -1.28555 18.6 59
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Anaphase-promoting complex subunit 10 ANAPC10 Tbio Enzyme -1.23751 18.1 156