Development Level

Tbio 65 | 10,625
Tchem 22 | 1,890
Tclin 8 | 602
Tdark 3 | 7,003

IMPC Phenotype

preweaning lethality, complete... 12 | 633
embryonic lethality prior to o... 4 | 148
prenatal lethality prior to he... 2 | 64
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal pharyngeal arch morph... 1 | 2
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating insulin ... 1 | 75
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
polydactyly 1 | 22
small testis 1 | 37

Disease

ovarian cancer 68 | 8,491
psoriasis 53 | 6,685
lung cancer 51 | 4,473
osteosarcoma 45 | 7,933
malignant mesothelioma 40 | 3,163
medulloblastoma, large-cell 40 | 6,234
glioblastoma 39 | 5,572
non-small cell lung cancer 37 | 2,798
group 3 medulloblastoma 31 | 2,254
Multiple myeloma 30 | 1,327
primitive neuroectodermal tumor 28 | 3,031
Breast cancer 24 | 3,098
Cancer 24 | 2,346
adrenocortical carcinoma 23 | 1,427
atypical teratoid / rhabdoid tumor 22 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,289
pediatric high grade glioma 22 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
lung adenocarcinoma 20 | 2,714
invasive ductal carcinoma 17 | 2,950
Waldenstrons macroglobulinemia 16 | 764
HIV Infections 15 | 99
nasopharyngeal carcinoma 15 | 1,056
oligodendroglioma 14 | 2,849
posterior fossa group A ependymoma 14 | 1,511
colon cancer 13 | 1,475
dermatomyositis 13 | 966
ductal carcinoma in situ 12 | 1,745
Endometriosis 11 | 535
astrocytoma 11 | 1,493
atypical teratoid/rhabdoid tumor 9 | 1,095
Seckel syndrome 8 | 35
astrocytic glioma 8 | 2,241
diabetes mellitus 8 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
primary Sjogren syndrome 8 | 788
Meier-Gorlin syndrome 7 | 12
juvenile dermatomyositis 7 | 1,189
non primary Sjogren syndrome sicca 7 | 840
pancreatic cancer 7 | 2,300
pilocytic astrocytoma 7 | 3,086
pituitary cancer 7 | 1,972
sonic hedgehog group medulloblastoma 7 | 1,482
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 1,563
Atopic dermatitis 6 | 944
IGA Glomerulonephritis 6 | 454
acute myeloid leukemia 6 | 785
breast carcinoma 6 | 1,614
ependymoma 6 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung carcinoma 6 | 2,844
medulloblastoma 6 | 1,524
ulcerative colitis 6 | 2,087
Carcinoma 5 | 2,147
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Mantle cell lymphoma 5 | 20
Pick disease 5 | 1,893
adult high grade glioma 5 | 2,148
primary pancreatic ductal adenocarcinoma 5 | 1,271
Bladder Neoplasm 4 | 109
Colonic Neoplasms 4 | 126
Colorectal Neoplasms 4 | 217
Peripheral Neuropathy 4 | 303
Squamous cell carcinoma of esophagus 4 | 82
active Crohn's disease 4 | 918
acute quadriplegic myopathy 4 | 1,157
esophageal adenocarcinoma 4 | 737
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 16
Acute promyelocytic leukemia, FAB M3 3 | 10
Adenocarcinoma of pancreas 3 | 12
Adenoma 3 | 165
Alzheimer's disease 3 | 644
Ataxia telangiectasia 3 | 32
Cockayne syndrome 3 | 54
Kidney cancer 3 | 121
Liver carcinoma 3 | 217
Lung Neoplasms 3 | 171
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
Microcephaly 3 | 149
Xeroderma pigmentosum 3 | 41
cutaneous lupus erythematosus 3 | 1,056
cystic fibrosis 3 | 1,670
gastric cancer 3 | 436
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
inflammatory breast cancer 3 | 404
interstitial cystitis 3 | 2,299
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Duchenne muscular dystrophy 2 | 602
Parkinson's disease 2 | 364
Prostatic Neoplasms 2 | 471
Stomach Neoplasms 2 | 282
hepatocellular carcinoma 2 | 550
non-small cell lung carcinoma 2 | 413

Tissue

Blood and immune system 98 | 17,994
Digestive Tract 98 | 18,472
Endocrine System 98 | 18,511
Female tissues 98 | 18,646
Liver and Pancreas 98 | 18,135
Male tissues 98 | 17,968
Nervous System 98 | 18,560
Urinary Tract 98 | 18,443
Cardiovascular System 97 | 17,957
Respiratory system 97 | 17,483
Skin and soft tissues 97 | 18,114

Target Family

Enzyme 56 | 4,146
Non-IDG 41 | 11,969
Kinase 1 | 634

Reactome Pathway

Synthesis of DNA 98 | 98
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.77039 58.7 182
Flap endonuclease 1 FEN1 Tchem Enzyme -2.77484 533.8 332
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.36530 2.18 29
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.41871 2399.0 886
DNA replication factor Cdt1 CDT1 Tbio Non-IDG -2.17234 139.2 105
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.08011 105.8 227
Proteasome activator complex subunit 1 PSME1 Tbio Non-IDG -1.72065 54.6 204