Development Level

Tbio 6 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal testis morphology 1 | 43
decreased circulating insulin ... 1 | 76
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
hydrometra 1 | 53
preweaning lethality, complete... 1 | 979
small testis 1 | 58

Disease

Atherosclerosis 4 | 291
Coronary artery disease 4 | 268
Depressive disorder 4 | 409
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
primary pancreatic ductal adenocarcinoma 4 | 1,109
Amyotrophic lateral sclerosis 3 | 451
Anxiety 3 | 136
Anxiety disease 3 | 113
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Cancer 3 | 2,499
Cardiovascular Diseases 3 | 59
Dyspnea 3 | 76
Fatigable weakness of respiratory muscles 3 | 28
Fatigable weakness of swallowing muscles 3 | 28
Fatigue 3 | 182
Fatty Liver 3 | 70
Generalized muscle weakness 3 | 57
Mammary Neoplasms 3 | 425
Mood swings 3 | 77
Muscle Cramp 3 | 55
Muscle Spasticity 3 | 195
Nerve Degeneration 3 | 121
Neuro-degenerative disease 3 | 43
Neurodegenerative Disorders 3 | 79
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Pain 3 | 103
Paralysed 3 | 42
Respiratory Failure 3 | 104
Schizophrenia 3 | 1,160
Skeletal muscle atrophy 3 | 139
Xerostomia 3 | 42
adrenocortical carcinoma 3 | 1,428
diabetes mellitus 3 | 1,728
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
muscle degeneration 3 | 139
non-small cell lung cancer 3 | 2,890
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
pancreatic cancer 3 | 2,398
Asthma 2 | 385
Autistic Disorder 2 | 364
Carcinoma 2 | 11,493
Cerebrovascular disease 2 | 238
Down syndrome 2 | 499
Heart failure 2 | 162
Hypercholesterolemia, Familial 2 | 23
Hyperlipoproteinemia Type II 2 | 12
Hypertension 2 | 396
Hyperthyroidism 2 | 53
Infertility, Male 2 | 46
Lung Neoplasms 2 | 232
Male infertility 2 | 206
Muscle hypotonia 2 | 571
Neurotoxicity Syndromes 2 | 26
Obesity 2 | 678
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
group 3 medulloblastoma 2 | 4,104
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary Sjogren syndrome 2 | 735
psoriasis 2 | 6,694
tuberculosis and treatment for 3 months 2 | 179
Acrocephaly 1 | 12
Acute coronary syndrome 1 | 39
Amyotrophic lateral sclerosis type 1 1 | 23
Atrioventricular block 1 | 35
Bipolar I disorder 1 | 23
Brain Neoplasms 1 | 33
Carcinoma, Squamous Cell 1 | 110
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Diabetic retinopathy 1 | 56
Drug allergy 1 | 36
Fibrosis 1 | 44
Flared iliac wings 1 | 13
Glucose Intolerance 1 | 19
Head and Neck Neoplasms 1 | 26
Heart Diseases 1 | 43
Hepatitis, Chronic 1 | 23
Hyperglycemia 1 | 137
Impaired glucose tolerance 1 | 28
Keshan disease 1 | 17
Metabolic Syndrome 1 | 20
Neuroectodermal Tumor, Primitive 1 | 8
Neuroectodermal Tumors, Primitive 1 | 8
Periodontal Diseases 1 | 21
Platyspondyly 1 | 56
Porencephaly 1 | 20
Rhinitis 1 | 54
Short hands 1 | 50
Short ribs 1 | 30

Tissue

Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Blood and immune system 7 | 16,909
Cardiovascular System 6 | 15,192

Target Family

Enzyme 8 | 4,145

Reactome Pathway

Synthesis of 5-eicosatetraenoi... 8 | 8
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 Tbio Enzyme -2.88891 707.6 227
Leukotriene C4 synthase LTC4S Tchem Enzyme -1.98032 93.9 89
Glutathione peroxidase 2 GPX2 Tbio Enzyme -2.29928 197.6 144
Glutathione peroxidase 1 GPX1 Tbio Enzyme -2.94289 886.7 350
Serum paraoxonase/lactonase 3 PON3 Tbio Enzyme -1.89828 64.7 182
Serum paraoxonase/arylesterase 1 PON1 Tbio Enzyme -3.39345 2648.8 361
Arachidonate 5-lipoxygenase-activating protein ALOX5AP Tchem Enzyme -2.68134 446.8 174
Serum paraoxonase/arylesterase 2 PON2 Tbio Enzyme -2.22981 162.9 308