Development Level

Tbio 5 | 11,651
Tchem 1 | 1,388

IMPC Phenotype

hydrometra 2 | 53
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
decreased circulating insulin ... 1 | 76
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Cancer 4 | 2,499
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Mammary Neoplasms 3 | 425
Anhidrosis 2 | 23
Autosomal recessive congenital ichthyosis 2 | 11
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital ichthyosiform erythroderma 2 | 28
Congenital ichthyosis 2 | 3
Congenital non-bullous ichthyosiform erythroderma 2 | 7
Fatty Liver 2 | 70
Hypertension 2 | 396
Hypertensive disease 2 | 292
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 2 | 3
Ichthyosiform erythroderma, Brocq congenital, nonbullous form 2 | 2
Ichthyosis 2 | 56
Ichthyosis, Congenital, Autosomal Recessive 2 2 | 3
Ichthyosis, Lamellar 2 | 4
Schizophrenia 2 | 1,160
Self-Healing Collodion Baby 2 | 3
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
primary pancreatic ductal adenocarcinoma 2 | 1,109
psoriasis 2 | 6,694
11 pairs of ribs 1 | 7
Abdominal aortic aneurysm 1 | 9
Abnormal helices 1 | 11
Abnormality of the ribs 1 | 32
Abnormality of the scapula 1 | 3
Acrocephaly 1 | 12
Actinic keratosis 1 | 21
Atrial Septal Defects 1 | 85
Atrioventricular block 1 | 35
Atrioventricular nodal disease 1 | 10
Brachydactyly 1 | 156
Brachyolmia 1 | 5
Carcinoma, Squamous Cell 1 | 110
Cardiopulmonary Arrest 1 | 3
Cone-shaped epiphyses of phalanges 1 | 15
Corneal erosion 1 | 16
Cupped ribs 1 | 3
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Diabetes Mellitus, Experimental 1 | 108
Disproportionately long fibula 1 | 4
Dry skin 1 | 75
Ectropion 1 | 38
Embryo Loss 1 | 7
Esophageal Neoplasms 1 | 69
Everted lower lip vermilion 1 | 54
Exfoliative dermatitis 1 | 24
Fibrosis 1 | 44
Flared iliac wings 1 | 13
Flared ribs 1 | 3
Flat acetabular roof 1 | 10
Generalized hypotonia 1 | 37
Glucose Intolerance 1 | 19
Hair shaft abnormalities 1 | 30
Head and Neck Neoplasms 1 | 26
Hepatitis, Chronic 1 | 23
Hyperglycemia 1 | 137
Hyperinsulinism 1 | 133
Hyperkeratosis 1 | 50
Hyperthyroidism 1 | 53
Hypoplastic finger 1 | 17
Hypoplastic toes 1 | 29
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 1 | 1
Ichthyosiform Erythroderma, Congenital 1 | 6
Ichthyosis, Lamellar, 5 1 | 1
Impaired glucose tolerance 1 | 28
Irregular lacy iliac crest 1 | 3
Keshan disease 1 | 17
Lack of skin elasticity 1 | 10
Metaphyseal chondrodysplasia 1 | 7
Metaphyseal cupping 1 | 10
Metaphyseal irregularity 1 | 23
Nail Diseases 1 | 24
Nail abnormality 1 | 22
Narrow sacrosciatic notch 1 | 6
Narrow thorax 1 | 53
Palmoplantar keratosis 1 | 74
Paralysed 1 | 42
Platyspondyly 1 | 56
Porencephaly 1 | 20
Protruding lower lip 1 | 54
Pruritus 1 | 58
Residual schizophrenia 1 | 2
Rhizomelia 1 | 25
Short finger 1 | 17
Short hands 1 | 50
Short phalanx of finger 1 | 32
Short ribs 1 | 30
Short tubular bones 1 | 22
Squamous cell carcinoma 1 | 129
Stretched skin 1 | 10
Strudwick syndrome 1 | 5
Xerosis 1 | 75
hair abnormalities (non-specific) 1 | 30
inflammatory breast cancer 1 | 286
uncontrolled asthma 1 | 56

Tissue

Blood and immune system 6 | 16,909
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Skin and soft tissues 6 | 17,230
Liver and Pancreas 5 | 16,750
Urinary Tract 5 | 16,678
Respiratory system 4 | 16,393
Cardiovascular System 3 | 15,192

Target Family

Enzyme 6 | 4,145

Reactome Pathway

Synthesis of 12-eicosatetraeno... 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroperoxide isomerase ALOXE3 ALOXE3 Tbio Enzyme -1.51120 32.2 118
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 Tbio Enzyme -2.88891 707.6 227
Arachidonate 12-lipoxygenase, 12R-type ALOX12B Tbio Enzyme -1.33994 24.1 71
Glutathione peroxidase 1 GPX1 Tbio Enzyme -2.94289 886.7 350
Glutathione peroxidase 2 GPX2 Tbio Enzyme -2.29928 197.6 144
Arachidonate 15-lipoxygenase ALOX15 Tchem Enzyme -2.43772 277.6 185