Development Level

Tbio 4 | 11,445
Tchem 4 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

abnormal behavior 2 | 298
hypoactivity 2 | 132
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
enlarged heart 1 | 210
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
scaly skin 1 | 4
thick skin 1 | 4

Disease

diabetes mellitus 6 | 1,728
ovarian cancer 6 | 8,520
Breast cancer 4 | 3,578
Carcinoma 4 | 11,493
Obesity 4 | 678
ependymoma 4 | 4,679
interstitial cystitis 4 | 2,312
malignant mesothelioma 4 | 3,232
psoriasis 4 | 6,694
active Crohn's disease 3 | 922
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
ulcerative colitis 3 | 1,819
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Cancer 2 | 2,499
Cognitive delay 2 | 608
Congenital heart disease 2 | 93
Congenital hypoplasia of penis 2 | 176
Cryptorchidism 2 | 296
Global developmental delay 2 | 608
Hyperglycemia 2 | 137
Hypoglycemia 2 | 152
Hypoplastic mandible condyle 2 | 275
Isolated growth hormone deficiency 2 | 30
Mandibular hypoplasia 2 | 275
Mental and motor retardation 2 | 608
Micrognathism 2 | 275
Multiple myeloma 2 | 1,332
Penile hypospadias 2 | 106
Pituitary hypoplasia 2 | 23
Primary physiologic amenorrhea 2 | 55
Short stature 2 | 531
Small head 2 | 374
Streak ovary 2 | 15
atypical teratoid / rhabdoid tumor 2 | 5,112
dermatomyositis 2 | 966
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
46,XY partial gonadal dysgenesis 1 | 9
Abnormal nasal morphology 1 | 16
Abnormal sex determination 1 | 11
Abnormality of the labia 1 | 9
Abnormality of the scrotum 1 | 9
Aniridia 1 | 25
Anterior Segment Dysgenesis 5 1 | 4
Atrioventricular Septal Defect 1 | 22
Axenfeld-Rieger Syndrome, Type 1 1 | 3
Biopsy shows villous atrophy 1 | 16
CATARACT, AUTOSOMAL DOMINANT 1 | 4
Coloboma of eyelid 1 | 15
Coloboma of lens 1 | 4
Coloboma of macula 1 | 4
Congenital coloboma of iris 1 | 4
Congenital neurologic anomalies 1 | 20
Decreased fertility in females 1 | 20
Diaphragmatic Hernia 1 | 40
Disorder of the optic nerve 1 | 1
Duodenal villous atrophy 1 | 16
Ebstein anomaly 1 | 16
Ectropion 1 | 38
Elevated follicle stimulating hormone 1 | 15
Elevated luteinizing hormone 1 | 14
Enlarged thorax 1 | 18
Female external genitalia in males 1 | 13
Generalized hyperpigmentation 1 | 22
Heart Septal Defects, Ventricular 1 | 6
Hereditary macular coloboma 1 | 5
Hernia, Diaphragmatic 1 | 40
Hernias, Diaphragmatic, Congenital 1 | 17
Hyperphagia 1 | 23
Hypoplasia of vagina 1 | 14
Hypospadias, perineal 1 | 5
Increased appetite (finding) 1 | 23
Insulinoma 1 | 24
Keratopathy 1 | 12
Persistent hyperplastic primary vitreous 1 | 20
Peters anomaly 1 | 16
Presenile cataract 1 | 1
Red hair 1 | 6
Rudimentary vagina 1 | 14
Scanning speech 1 | 9
Scleral staphyloma 1 | 1
Secondary Adrenal Insufficiency 1 | 6
Small intestine biopsy shows villous atrophy 1 | 16
Testicular regression syndrome 1 | 9
Urogenital sinus anomaly 1 | 15
Variable degree of villous atrophy 1 | 16
Villous atrophy 1 | 16
Villous atrophy of intestine 1 | 16
WAGR syndrome 1 | 10
Waardenburg's syndrome 1 | 17

Tissue

Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Blood and immune system 11 | 16,909
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Respiratory system 11 | 16,393
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Skin and soft tissues 9 | 17,230
Urinary Tract 8 | 16,678
Cardiovascular System 7 | 15,192

Target Family

Enzyme 6 | 4,145
Transcription Factor 3 | 1,400
GPCR 2 | 408
Non-IDG 1 | 12,091

Reactome Pathway

Synthesis, secretion, and inac... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
Free fatty acid receptor 1 FFAR1 Tchem GPCR -2.43801 296.2 231
Signal peptidase complex subunit 2 SPCS2 Tdark Enzyme -0.26503 1.68 51
Glucose-dependent insulinotropic receptor GPR119 Tchem GPCR -2.06190 120.0 180
Transcription factor GATA-4 GATA4 Tbio Transcription Factor -2.90202 763.9 496
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Signal peptidase complex subunit 3 SPCS3 Tdark Enzyme -0.52720 4.04 50
Signal peptidase complex catalytic subunit SEC11A SEC11A Tbio Enzyme -0.76426 10.7 124