Development Level

Tbio 9 | 10,625
Tchem 6 | 1,890
Tdark 4 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, incomple... 2 | 260
abnormal bone mineralization 1 | 55
abnormal head morphology 1 | 10
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
oligodactyly 1 | 14
preweaning lethality, complete... 1 | 633
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

Obesity 10 | 616
diabetes mellitus 10 | 1,663
ovarian cancer 8 | 8,484
psoriasis 8 | 6,685
Cancer 7 | 2,346
active Crohn's disease 6 | 918
glioblastoma 6 | 5,572
lung carcinoma 6 | 2,844
medulloblastoma, large-cell 6 | 6,234
pituitary cancer 6 | 1,972
Breast cancer 5 | 3,094
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
interstitial cystitis 5 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
invasive ductal carcinoma 5 | 2,950
osteosarcoma 5 | 7,933
Colonic Neoplasms 4 | 126
Kidney disease 4 | 396
Metabolic syndrome X 4 | 155
atypical teratoid / rhabdoid tumor 4 | 4,369
ependymoma 4 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung cancer 4 | 4,466
malignant mesothelioma 4 | 3,162
oligodendroglioma 4 | 2,849
sonic hedgehog group medulloblastoma 4 | 1,482
ulcerative colitis 4 | 2,087
Adenoma 3 | 165
Alzheimer's disease 3 | 644
Carcinoma 3 | 2,147
Coronary artery disease 3 | 240
Fatty liver disease 3 | 84
Hyperglycemia 3 | 120
Hypertension 3 | 287
Hypertensive disease 3 | 193
Hypoglycemia 3 | 81
Lipid metabolism disorder 3 | 102
Liver disease 3 | 219
Pancreatitis 3 | 97
atypical teratoid/rhabdoid tumor 3 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
dermatomyositis 3 | 933
ductal carcinoma in situ 3 | 1,745
fibroadenoma 3 | 557
pancreatic cancer 3 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
primitive neuroectodermal tumor 3 | 3,031
Aberrant Crypt Foci 2 | 3
Acquired metabolic disease 2 | 267
Adenocarcinoma 2 | 115
Atherosclerosis 2 | 275
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Barrett's esophagus 2 | 183
Cerebrovascular disease 2 | 231
Colorectal Cancer 2 | 47
Colorectal Neoplasms 2 | 217
Craniofacial Abnormalities 2 | 147
Heart disease 2 | 279
Hyperinsulinism 2 | 63
Hyperthyroidism 2 | 50
Hypothyroidism 2 | 89
Intellectual disability 2 | 573
Intestinal benign neoplasm 2 | 11
Liver Neoplasms, Experimental 2 | 48
Mammary Neoplasms 2 | 410
Melanoma 2 | 261
Multiple myeloma 2 | 1,327
Neoplasm Invasiveness 2 | 127
Nerve Degeneration 2 | 73
Osteoporosis 2 | 257
Pick disease 2 | 1,893
Pituitary hypoplasia 2 | 15
Prostatic Neoplasms 2 | 471
Proteinuria 2 | 63
Rheumatoid Arthritis 2 | 1,160
Seizures 2 | 95
Tachycardia 2 | 17
Type 2 diabetes mellitus 2 | 189
Vascular disease 2 | 281
Weight Gain 2 | 87
astrocytoma 2 | 1,493
breast carcinoma 2 | 1,614
group 3 medulloblastoma 2 | 2,254
group 4 medulloblastoma 2 | 1,875
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
non-small cell lung carcinoma 2 | 413
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
Anovulation 1 | 20
Colon Carcinoma 1 | 25
Endometrial cancer 1 | 25
Hyperactive behavior 1 | 31
Nasopharyngitis 1 | 11

Tissue

Digestive Tract 20 | 18,473
Endocrine System 20 | 18,512
Female tissues 20 | 18,647
Liver and Pancreas 20 | 18,136
Nervous System 20 | 18,561
Skin and soft tissues 20 | 18,115
Blood and immune system 19 | 17,995
Cardiovascular System 19 | 17,958
Male tissues 19 | 17,969
Urinary Tract 19 | 18,444
Respiratory system 17 | 17,484

Target Family

Enzyme 7 | 4,146
Non-IDG 7 | 11,971
GPCR 3 | 406
Transcription Factor 3 | 1,400

Reactome Pathway

Synthesis, secretion, and inac... 20 | 20
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucagon GCG Tchem Non-IDG -4.21000 16535.4 929
Free fatty acid receptor 4 FFAR4 Tchem GPCR -2.03326 135.1 233
Signal peptidase complex subunit 3 SPCS3 Tdark Enzyme -0.54407 3.96 39
Dipeptidyl peptidase 4 DPP4 Tclin Enzyme -3.56195 4091.0 900
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46489 3.55 21
Homeobox protein CDX-2 CDX2 Tbio Transcription Factor -2.86354 784.9 526
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.12601 1375.5 488
Guanine nucleotide-binding protein G(t) subunit alpha-3 GNAT3 Tbio Non-IDG -2.24540 179.5 101
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.33490 231.5 154
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.73970 6.42 30