Development Level

Tbio 8 | 11,651
Tchem 6 | 1,388
Tdark 4 | 6,593
Tclin 1 | 612

IMPC Phenotype

abnormal behavior 2 | 298
decreased lean body mass 2 | 135
hypoactivity 2 | 132
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal head morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
decreased respiratory quotient 1 | 16
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased lean body mass 1 | 172
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
preweaning lethality, complete... 1 | 979
scaly skin 1 | 4
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thick skin 1 | 4

Disease

diabetes mellitus 11 | 1,728
Obesity 10 | 678
ependymoma 8 | 4,679
ovarian cancer 8 | 8,520
Carcinoma 7 | 11,493
psoriasis 7 | 6,694
Breast cancer 6 | 3,578
Cancer 6 | 2,499
active Crohn's disease 6 | 922
glioblastoma 6 | 5,792
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
pituitary cancer 6 | 1,972
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Hyperglycemia 5 | 137
Schizophrenia 5 | 1,160
atypical teratoid / rhabdoid tumor 5 | 5,112
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
osteosarcoma 5 | 7,950
Alzheimer's disease 4 | 658
Colonic Neoplasms 4 | 142
Hypertension 4 | 396
Hypoglycemia 4 | 152
Kidney disease 4 | 430
Liver disease 4 | 237
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung cancer 4 | 4,740
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Astrocytoma, Pilocytic 3 | 3,081
Coronary artery disease 3 | 268
Depressive disorder 3 | 409
Fatty liver disease 3 | 103
Hypertensive disease 3 | 292
Lipid metabolism disorder 3 | 114
Mental Depression 3 | 333
Pancreatitis 3 | 123
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
fibroadenoma 3 | 559
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Abnormality of retinal pigmentation 2 | 111
Acquired metabolic disease 2 | 336
Adenoma 2 | 167
Alcoholic Intoxication, Chronic 2 | 289
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Breast Neoplasms 2 | 445
Cerebrovascular disease 2 | 238
Cholestasis 2 | 155
Colorectal Neoplasms 2 | 243
Craniofacial Abnormalities 2 | 151
Diarrhea 2 | 253
Heart disease 2 | 306
Hyperinsulinism 2 | 133
Hyperplasia 2 | 27
Hypogonadotropic hypogonadism 2 | 89
Hypothyroidism 2 | 122
Lung disease 2 | 142
Major Depressive Disorder 2 | 301
Malabsorption 2 | 82
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Metabolic syndrome X 2 | 52
Neoplasm Invasiveness 2 | 161
Nerve Degeneration 2 | 121
Neurodevelopmental Disorders 2 | 70
Osteoporosis 2 | 363
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Proteinuria 2 | 144
Retinal pigment epithelial abnormality 2 | 111
Seizures 2 | 596
Somatic mutation 2 | 61
Stomach Neoplasms 2 | 300
Strabismus 2 | 270
Tachycardia 2 | 43
Type 2 diabetes mellitus 2 | 272
Vascular disease 2 | 319
Weight Gain 2 | 100
astrocytic glioma 2 | 2,597
atypical teratoid/rhabdoid tumor 2 | 357
medulloblastoma 2 | 720
non-small cell lung carcinoma 2 | 317
pediatric high grade glioma 2 | 1,064
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010

Tissue

Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Liver and Pancreas 16 | 16,750
Nervous System 16 | 16,725
Blood and immune system 15 | 16,909
Female tissues 15 | 17,400
Male tissues 15 | 17,142
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 13 | 16,678
Cardiovascular System 12 | 15,192

Target Family

Enzyme 7 | 4,145
Non-IDG 7 | 12,091
GPCR 3 | 408
Transcription Factor 2 | 1,400

Reactome Pathway

Synthesis, secretion, and inac... 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Glucagon GCG Tchem Non-IDG -4.23329 17114.4 1097
Signal peptidase complex subunit 3 SPCS3 Tdark Enzyme -0.52720 4.04 50
Signal peptidase complex subunit 2 SPCS2 Tdark Enzyme -0.26503 1.68 51
Guanine nucleotide-binding protein G(t) subunit alpha-3 GNAT3 Tbio Non-IDG -2.28370 189.3 111
Free fatty acid receptor 4 FFAR4 Tchem GPCR -2.18062 163.8 246
Dipeptidyl peptidase 4 DPP4 Tclin Enzyme -3.64553 4548.3 1169