Development Level

Tbio 20 | 10,625
Tchem 6 | 1,890

IMPC Term

abnormal behavior 2 | 226
hyperactivity 2 | 108
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
decreased circulating serum al... 1 | 79
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
hypoactivity 1 | 89
increased bone mineral density 1 | 52
increased lean body mass 1 | 107
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 14 | 8,484
osteosarcoma 13 | 7,933
psoriasis 11 | 6,685
medulloblastoma, large-cell 9 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
lung cancer 8 | 4,466
Cancer 7 | 2,346
Homocystinuria 7 | 23
Hyperhomocysteinemia 7 | 34
malignant mesothelioma 7 | 3,162
colon cancer 6 | 1,475
Down syndrome 5 | 548
Hypermethioninemia 5 | 12
adrenocortical carcinoma 5 | 1,427
cystic fibrosis 5 | 1,665
group 4 medulloblastoma 5 | 1,875
subependymal giant cell astrocytoma 5 | 2,287
Cleft Lip 4 | 91
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Multiple myeloma 4 | 1,327
gastric carcinoma 4 | 832
interstitial cystitis 4 | 2,299
invasive ductal carcinoma 4 | 2,950
non-small cell lung cancer 4 | 2,798
pancreatic cancer 4 | 2,300
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 674
Amino Acid Metabolism, Inborn Errors 3 | 13
Atopic dermatitis 3 | 944
Cleft palate 3 | 125
Liver Cirrhosis, Experimental 3 | 108
Methylmalonic acidemia 3 | 39
Pick disease 3 | 1,893
Prostatic Neoplasms 3 | 471
Vascular disease 3 | 281
atypical teratoid/rhabdoid tumor 3 | 1,095
glioblastoma 3 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung carcinoma 3 | 2,844
oligodendroglioma 3 | 2,849
spina bifida 3 | 1,064
tuberculosis 3 | 1,557
tuberculosis and treatment for 3 months 3 | 327
Adverse reaction to drug 2 | 54
Ancylostomiasis 2 | 6
Aphasia 2 | 22
Apraxia 2 | 25
Atherosclerosis 2 | 275
Brain disease 2 | 83
Dementia 2 | 129
Dystonia 2 | 77
Frontotemporal dementia 2 | 41
Gerstmann syndrome 2 | 2
Hepatolenticular Degeneration 2 | 24
Histidinemia 2 | 9
Hypertensive disease 2 | 193
Liver carcinoma 2 | 217
Lymphoma, Non-Hodgkin 2 | 22
Male infertility 2 | 170
Malnutrition 2 | 3
Myocardial Infarction 2 | 126
Neural tube defect, folate-sensitive 2 | 4
Neurodegenerative disease 2 | 383
Phaeohyphomycosis 2 | 8
Pityriasis versicolor 2 | 18
Tinea corporis 2 | 25
Tinea manuum 2 | 4
Toxic encephalopathy 2 | 131
Voyeurism 2 | 4
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
ductal carcinoma in situ 2 | 1,745
fibroadenoma 2 | 557
hepatocellular carcinoma 2 | 532
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
nephrosclerosis 2 | 329
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
primitive neuroectodermal tumor 2 | 3,031
ulcerative colitis 2 | 2,087
Animal Mammary Neoplasms 1 | 136
Azoospermia 1 | 89
Drug-Induced Liver Injury 1 | 118
Leukoencephalopathies 1 | 7
Long QT syndrome 1 | 52
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 150
Mastitis 1 | 48
Melanoma 1 | 261
OROFACIAL CLEFT 1 1 | 2
Osteopetrosis 1 | 40
Refractive Errors 1 | 18
Vaccinia 1 | 37
Vitamin B12 deficiency 1 | 20
interstitial lung disease 1 | 291
non-inflammatory breast cancer 1 | 208

Tissue

Blood and immune system 26 | 17,995
Cardiovascular System 26 | 17,958
Digestive Tract 26 | 18,473
Female tissues 26 | 18,647
Liver and Pancreas 26 | 18,136
Male tissues 26 | 17,969
Nervous System 26 | 18,561
Endocrine System 25 | 18,512
Respiratory system 25 | 17,484
Skin and soft tissues 25 | 18,115
Urinary Tract 25 | 18,444

Target Family

Enzyme 24 | 4,146
Non-IDG 1 | 11,971
Transporter 1 | 473

Reactome Pathway

Sulfur amino acid metabolism 26 | 26
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutamate--cysteine ligase regulatory subunit GCLM Tbio Enzyme -2.16651 142.7 233
Glutamate--cysteine ligase catalytic subunit GCLC Tchem Enzyme -2.40511 266.2 257
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.45921 2982.0 0
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tchem Enzyme -1.98654 96.6 154
Sulfide:quinone oxidoreductase, mitochondrial SQRDL Tbio Enzyme -1.04064 12.9 74
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.32487 206.5 107
Sulfite oxidase, mitochondrial SUOX Tbio Enzyme -1.99744 106.9 229
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.12492 135.4 119
S-adenosylmethionine synthase isoform type-1 MAT1A Tbio Enzyme -2.07868 120.8 147
Methionine synthase MTR Tbio Enzyme -2.55298 290.0 77