Development Level

Tbio 20 | 11,651
Tchem 4 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hypoactivity 1 | 132
increased lean body mass 1 | 172
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 15 | 11,493
ovarian cancer 11 | 8,519
psoriasis 10 | 6,694
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
Autosomal recessive predisposition 8 | 1,442
Cancer 7 | 2,499
Homocystinuria 7 | 21
Hyperhomocysteinemia 7 | 37
malignant mesothelioma 6 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
spina bifida 6 | 1,074
Cognitive delay 5 | 608
Epilepsy 5 | 792
Global developmental delay 5 | 608
Hypermethioninemia 5 | 11
Mental and motor retardation 5 | 608
Seizures 5 | 596
adrenocortical carcinoma 5 | 1,428
cystic fibrosis 5 | 1,695
invasive ductal carcinoma 5 | 2,950
lung cancer 5 | 4,740
Atherosclerosis 4 | 291
Cleft Lip 4 | 141
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Down syndrome 4 | 499
Dull intelligence 4 | 645
Failure to gain weight 4 | 365
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Melanoma 4 | 711
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,744
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
oligodendroglioma 4 | 2,850
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Cleft Palate 3 | 271
Dystonia 3 | 164
Ethylmalonic encephalopathy 3 | 12
Liver Cirrhosis, Experimental 3 | 769
Methylmalonic acidemia 3 | 37
Muscle hypotonia 3 | 571
Neurodegenerative disease 3 | 414
Pick disease 3 | 1,894
Schizophrenia 3 | 1,160
Vascular disease 3 | 319
atypical teratoid/rhabdoid tumor 3 | 357
gastric carcinoma 3 | 807
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,290
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Adverse reaction to drug 2 | 61
Anemia 2 | 365
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,577
Carcinoma, Hepatocellular 2 | 228
Cardiovascular system disease 2 | 246
Cerebral atrophy 2 | 178
Degenerative brain disorder 2 | 100
Dementia 2 | 175
Depressive disorder 2 | 409
Frontotemporal dementia 2 | 51
Glaucoma 2 | 239
Hypertension 2 | 396
Infantile onset 2 | 238
Infertility, Male 2 | 46
Liver carcinoma 2 | 240
Lymphoma, Non-Hodgkin 2 | 24
Male infertility 2 | 206
Malnutrition 2 | 11
Neural tube defect, folate-sensitive 2 | 4
Prostatic Neoplasms 2 | 495
Supratentorial atrophy 2 | 94
Tinea corporis 2 | 25
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,637
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,954
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
tuberculosis and treatment for 3 months 2 | 179

Tissue

Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Respiratory system 24 | 16,393

Target Family

Enzyme 22 | 4,145
Non-IDG 2 | 12,091
Transporter 1 | 473

Reactome Pathway

Sulfur amino acid metabolism 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355
Thioredoxin, mitochondrial TXN2 Tbio Non-IDG -2.05954 125.2 260
S-adenosylmethionine synthase isoform type-1 MAT1A Tbio Enzyme -2.11527 125.3 167
Enolase-phosphatase E1 ENOPH1 Tbio Enzyme -0.98363 9.96 124
Sulfite oxidase, mitochondrial SUOX Tbio Enzyme -2.03377 111.1 244
Betaine--homocysteine S-methyltransferase 1 BHMT Tchem Enzyme -2.18155 160.8 309
Adenosylhomocysteinase AHCY Tchem Enzyme -2.69517 493.7 257
S-methylmethionine--homocysteine S-methyltransferase BHMT2 BHMT2 Tchem Enzyme -0.99513 9.54 87
Cysteine dioxygenase type 1 CDO1 Tbio Enzyme -1.58332 35.3 90
Mitochondrial dicarboxylate carrier SLC25A10 Tbio Transporter -1.25522 17.2 72