Development Level

Tbio 32 | 11,445
Tclin 1 | 613

IMPC Phenotype

abnormal behavior 2 | 298
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased circulating chloride... 2 | 41
preweaning lethality, complete... 2 | 979
abnormal behavioral response t... 1 | 66
abnormal heart morphology 1 | 162
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
increased anxiety-related resp... 1 | 2
increased blood uric acid leve... 1 | 5
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased startle reflex 1 | 112
long tibia 1 | 25

Disease

Carcinoma 20 | 11,493
psoriasis 17 | 6,694
Hypertrophic Cardiomyopathy 15 | 117
Dilated cardiomyopathy 13 | 56
acute quadriplegic myopathy 13 | 1,158
glioblastoma 13 | 5,792
Cardiomyopathy 12 | 116
Cardiomyopathy, Dilated 12 | 83
Distal arthrogryposis 12 | 42
atypical teratoid / rhabdoid tumor 12 | 5,112
Autosomal recessive predisposition 11 | 1,442
Breast cancer 11 | 3,578
Myopathy 11 | 185
ovarian cancer 11 | 8,520
Familial isolated dilated cardiomyopathy 10 | 41
LEFT VENTRICULAR NONCOMPACTION 10 10 | 40
LEFT VENTRICULAR NONCOMPACTION 8 10 | 40
lung cancer 10 | 4,740
medulloblastoma, large-cell 10 | 6,241
group 3 medulloblastoma 9 | 4,104
Acquired scoliosis 8 | 281
Curvature of spine 8 | 282
Duchenne muscular dystrophy 8 | 601
ependymoma 8 | 4,679
malignant mesothelioma 8 | 3,232
osteosarcoma 8 | 7,950
primitive neuroectodermal tumor 8 | 3,035
Arthrogryposis 7 | 54
Congestive heart failure 7 | 113
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
pancreatic cancer 7 | 2,398
Astrocytoma, Pilocytic 6 | 3,081
Byzanthine arch palate 6 | 194
Cardiomyopathy, Hypertrophic, Familial 6 | 9
Congenital clubfoot 6 | 109
Distal arthrogryposis syndrome 6 | 8
Kidney cancer 6 | 2,613
colon cancer 6 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung carcinoma 6 | 2,843
ARTHROGRYPOSIS, DISTAL, TYPE 1 5 | 6
Adducted thumb 5 | 22
Amyotrophic lateral sclerosis 5 | 451
Becker muscular dystrophy 5 | 191
Bell Palsy 5 | 58
Blepharoptosis 5 | 231
Cardiomyopathy, Hypertrophic 5 | 24
Clubfoot 5 | 39
Digitotalar dysmorphism 5 | 6
Facial Paresis 5 | 59
Facial muscle weakness of muscles innervated by CN VII 5 | 58
Flexion contracture of proximal interphalangeal joint 5 | 75
Heart disease 5 | 306
Heart failure 5 | 162
Hypoplastic mandible condyle 5 | 275
Joint stiffness 5 | 84
Left ventricular noncompaction 5 | 26
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Metatarsus Varus 5 | 24
Micrognathism 5 | 275
Narrow face 5 | 54
Nemaline myopathy 5 | 17
Overlapping fingers 5 | 10
Primary cutaneous amyloidosis 5 | 29
Short stature 5 | 531
Skin cancer 5 | 469
Talipes 5 | 20
Talipes foot deformities 5 | 20
Thin face 5 | 54
Toeing-in 5 | 24
Ulnar deviation of the fingers 5 | 21
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
juvenile dermatomyositis 5 | 1,187
limb girdle muscular dystrophy 2A 5 | 213
non-small cell lung cancer 5 | 2,890
Bilateral single transverse palmar creases 4 | 34
Broad flat nasal bridge 4 | 236
Cerebrovascular disease 4 | 238
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Long philtrum 4 | 137
Microstomia 4 | 78
Motor delay 4 | 147
Multiple pterygium syndrome 4 | 18
Muscle biopsy shows dystrophic changes 4 | 39
Muscular dystrophy 4 | 75
Nasal bridge wide 4 | 236
No development of motor milestones 4 | 147
Prominent ear 4 | 56
Protruding ears 4 | 56
Triangular face 4 | 58
Vertical Talus 4 | 25
fibroadenoma 4 | 559

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Male tissues 33 | 17,142
Skin and soft tissues 33 | 17,230
Urinary Tract 32 | 16,678
Blood and immune system 31 | 16,909
Cardiovascular System 31 | 15,192
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Nervous System 29 | 16,725
Respiratory system 27 | 16,393

Target Family

Non-IDG 32 | 12,091
Kinase 1 | 634

Reactome Pathway

Striated Muscle Contraction 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Myosin-8 MYH8 Tbio Non-IDG -1.71003 48.7 39
Myosin-6 MYH6 Tbio Non-IDG -2.95952 901.3 45
Titin TTN Tbio Kinase -3.24415 1743.0 123
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Myosin-3 MYH3 Tbio Non-IDG -1.74714 48.2 51
Alpha-actinin-3 ACTN3 Tbio Non-IDG 0.00000 150
Troponin I, slow skeletal muscle TNNI1 Tbio Non-IDG -1.62315 40.3 210
Myosin light chain 4 MYL4 Tbio Non-IDG -1.49231 30.1 171