Development Level

Tbio 57 | 11,445
Tchem 24 | 1,598
Tdark 6 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
increased mean corpuscular vol... 3 | 92
male infertility 3 | 123
preweaning lethality, complete... 3 | 979
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
thrombocytosis 2 | 27
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 58 | 11,493
ovarian cancer 49 | 8,520
glioblastoma 43 | 5,792
osteosarcoma 39 | 7,950
medulloblastoma, large-cell 33 | 6,241
psoriasis 33 | 6,694
atypical teratoid / rhabdoid tumor 28 | 5,112
ependymoma 27 | 4,679
invasive ductal carcinoma 26 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Astrocytoma, Pilocytic 21 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
tuberculosis 21 | 2,010
Breast cancer 19 | 3,578
lung cancer 19 | 4,740
malignant mesothelioma 19 | 3,232
group 4 medulloblastoma 16 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung adenocarcinoma 16 | 2,716
non-small cell lung cancer 16 | 2,890
adult high grade glioma 15 | 3,801
cystic fibrosis 15 | 1,696
ductal carcinoma in situ 15 | 1,745
subependymal giant cell astrocytoma 15 | 2,287
Autosomal recessive predisposition 14 | 1,442
group 3 medulloblastoma 14 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pancreatic cancer 13 | 2,398
Epilepsy 12 | 792
Multiple myeloma 12 | 1,332
interstitial cystitis 12 | 2,312
pediatric high grade glioma 12 | 1,064
Intellectual disability 11 | 1,016
astrocytoma 11 | 1,146
lung carcinoma 11 | 2,843
primary pancreatic ductal adenocarcinoma 11 | 1,109
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Neurodegenerative disease 10 | 414
Pick disease 10 | 1,894
Poor school performance 10 | 645
Seizures 10 | 596
diabetes mellitus 10 | 1,728
oligodendroglioma 10 | 2,850
pituitary cancer 10 | 1,972
ulcerative colitis 10 | 1,819
Gangliosidosis 9 | 20
Gaucher's disease 9 | 26
Rheumatoid arthritis 9 | 1,191
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
primitive neuroectodermal tumor 9 | 3,035
Atopic dermatitis 8 | 952
Cancer 8 | 2,499
Glycoproteinosis 8 | 12
Kidney cancer 8 | 2,613
Metachromatic leukodystrophy 8 | 14
Muscle hypotonia 8 | 571
Short stature 8 | 531
active ulcerative colitis 8 | 764
astrocytic glioma 8 | 2,597
esophageal adenocarcinoma 8 | 737
Cherry red spot of the macula 7 | 7
Cognitive delay 7 | 608
Congenital deafness 7 | 185
Deafness 7 | 198
Down syndrome 7 | 499
Global developmental delay 7 | 608
Hearing Loss, Partial 7 | 185
Hepatomegaly 7 | 285
Ichthyosis 7 | 56
Krabbe disease 7 | 12
Mental and motor retardation 7 | 608
Mucopolysaccharidosis 7 | 26
Splenomegaly 7 | 190
active Crohn's disease 7 | 922
breast carcinoma 7 | 1,638
hearing impairment 7 | 199
inclusion-cell disease 7 | 16
spina bifida 7 | 1,074
Alzheimer's disease 6 | 658
Cerebellar Ataxia 6 | 304
Chondrodysplasia punctata 6 | 41
Coarse facial features 6 | 108
Farber lipogranulomatosis 6 | 9
Leukodystrophy 6 | 55
Niemann-Pick disease 6 | 14
Thickened facial skin with coarse facial features 6 | 108
aldosterone-producing adenoma 6 | 665
cutaneous lupus erythematosus 6 | 1,057
juvenile dermatomyositis 6 | 1,187
non primary Sjogren syndrome sicca 6 | 891
progressive supranuclear palsy 6 | 676
acute myeloid leukemia 5 | 783
dermatomyositis 5 | 966
nasopharyngeal carcinoma 5 | 1,058
urothelial carcinoma 5 | 318

Tissue

Digestive Tract 86 | 17,369
Female tissues 86 | 17,400
Liver and Pancreas 86 | 16,750
Skin and soft tissues 86 | 17,230
Urinary Tract 86 | 16,678
Blood and immune system 85 | 16,909
Male tissues 85 | 17,142
Endocrine System 84 | 18,159
Nervous System 84 | 16,725
Respiratory system 83 | 16,393
Cardiovascular System 81 | 15,192

Target Family

Enzyme 63 | 4,145
Non-IDG 14 | 12,091
Kinase 7 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

Sphingolipid metabolism 89 | 89
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Galactocerebrosidase GALC Tbio Enzyme -2.56924 363.2 143
Arylsulfatase F ARSF Tbio Enzyme -0.44326 2.74 138
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Alkaline ceramidase 3 ACER3 Tbio Enzyme -2.07938 117.1 95
ORM1-like protein 2 ORMDL2 Tdark Non-IDG 0.06 0.61 64
Sphingosine-1-phosphate phosphatase 2 SGPP2 Tbio Enzyme -0.72925 6.15 77
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167
Arylsulfatase J ARSJ Tdark Enzyme -0.22432 1.18 25
Sphingosine-1-phosphate phosphatase 1 SGPP1 Tbio Enzyme -0.90666 6.54 76