Development Level

Tbio 28 | 11,445
Tchem 13 | 1,598
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

ovarian cancer 28 | 8,520
Carcinoma 23 | 11,493
medulloblastoma, large-cell 23 | 6,241
glioblastoma 22 | 5,792
osteosarcoma 22 | 7,950
invasive ductal carcinoma 20 | 2,951
psoriasis 19 | 6,694
atypical teratoid / rhabdoid tumor 15 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Astrocytoma, Pilocytic 14 | 3,081
Breast cancer 14 | 3,578
ependymoma 13 | 4,679
tuberculosis 13 | 2,010
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
non-small cell lung cancer 12 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung adenocarcinoma 11 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
adult high grade glioma 10 | 3,801
lung cancer 10 | 4,740
group 4 medulloblastoma 9 | 1,855
interstitial cystitis 9 | 2,312
malignant mesothelioma 9 | 3,232
cystic fibrosis 8 | 1,696
group 3 medulloblastoma 8 | 4,104
Multiple myeloma 7 | 1,332
breast carcinoma 7 | 1,638
lung carcinoma 7 | 2,843
pancreatic cancer 7 | 2,398
pediatric high grade glioma 7 | 1,064
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Down syndrome 6 | 499
Rheumatoid arthritis 6 | 1,191
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atopic dermatitis 5 | 952
Cancer 5 | 2,499
Pick disease 5 | 1,894
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
aldosterone-producing adenoma 5 | 665
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
esophageal adenocarcinoma 5 | 737
posterior fossa group A ependymoma 5 | 468
primitive neuroectodermal tumor 5 | 3,035
spina bifida 5 | 1,074
Neuronal ceroid lipofuscinosis 9 4 | 5
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Amyotrophic lateral sclerosis 3 | 451
Dull intelligence 3 | 645
Farber lipogranulomatosis 3 | 9
Ichthyosis 3 | 56
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Lipid storage disease 3 | 8
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Neurodegenerative disease 3 | 414
Neuropathy 3 | 261
Poor school performance 3 | 645
Retinitis pigmentosa 26 3 | 5
facioscapulohumeral dystrophy 3 | 288
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Alzheimer's disease 2 | 658
Bipolar Disorder 2 | 666
Chronic Lymphocytic Leukemia 2 | 262
Decreased tendon reflex 2 | 122
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Epilepsy 2 | 792
Liver cancer 2 | 604
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Reflex, Deep Tendon, Absent 2 | 92
acute myeloid leukemia 2 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
gastric cancer 2 | 459
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
mucosa-associated lymphoid tissue lymphoma 2 | 484
primary Sjogren syndrome 2 | 735
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis and treatment for 6 months 2 | 409
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 40 | 15,192

Target Family

Enzyme 25 | 4,145
Non-IDG 7 | 12,091
Kinase 6 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

Sphingolipid de novo biosynthe... 43 | 43
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alkaline ceramidase 3 ACER3 Tbio Enzyme -2.07938 117.1 95
ORM1-like protein 2 ORMDL2 Tdark Non-IDG 0.06 0.61 64
Sphingosine-1-phosphate phosphatase 2 SGPP2 Tbio Enzyme -0.72925 6.15 77
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167
Sphingosine-1-phosphate phosphatase 1 SGPP1 Tbio Enzyme -0.90666 6.54 76
Serine/threonine-protein kinase D3 PRKD3 Tchem Kinase -1.23218 13.2 295
Ceramide synthase 1 CERS1 Tbio Enzyme -1.58899 36.9 179
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0
3-ketodihydrosphingosine reductase KDSR Tbio Enzyme -1.21646 15.3 101
Oxysterol-binding protein 1 OSBP Tbio Non-IDG -2.22394 167.6 160