Development Level

Tbio 28 | 11,651
Tchem 3 | 1,388
Tdark 2 | 6,593

IMPC Phenotype

decreased body weight 2 | 161
increased startle reflex 2 | 112
abnormal bone structure 1 | 187
abnormal eye size 1 | 7
abnormal vibrissa morphology 1 | 25
decreased bone mineral content 1 | 151
decreased neutrophil cell numb... 1 | 42
increased blood urea nitrogen ... 1 | 48
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47

Disease

Carcinoma 21 | 11,493
glioblastoma 19 | 5,792
ovarian cancer 19 | 8,520
atypical teratoid / rhabdoid tumor 16 | 5,112
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
Breast cancer 14 | 3,578
invasive ductal carcinoma 14 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
medulloblastoma, large-cell 12 | 6,241
colon cancer 11 | 1,478
lung cancer 11 | 4,740
pancreatic cancer 11 | 2,398
cystic fibrosis 10 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung carcinoma 10 | 2,843
malignant mesothelioma 10 | 3,232
Astrocytoma, Pilocytic 9 | 3,081
acute quadriplegic myopathy 9 | 1,158
adult high grade glioma 9 | 3,801
breast carcinoma 9 | 1,638
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
subependymal giant cell astrocytoma 9 | 2,287
Cancer 8 | 2,499
group 4 medulloblastoma 8 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primitive neuroectodermal tumor 8 | 3,035
Duchenne muscular dystrophy 7 | 601
Kidney cancer 7 | 2,613
Liver Cirrhosis, Experimental 7 | 769
diabetes mellitus 7 | 1,728
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
Myopathy 6 | 185
ductal carcinoma in situ 6 | 1,745
juvenile dermatomyositis 6 | 1,187
ulcerative colitis 6 | 1,819
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
oligodendroglioma 5 | 2,850
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Atopic dermatitis 4 | 952
Autosomal recessive predisposition 4 | 1,442
Becker muscular dystrophy 4 | 191
Cardiomyopathy, Dilated 4 | 83
Hypertensive disease 4 | 292
Hypertrophic Cardiomyopathy 4 | 117
Intestinal pseudo-obstruction 4 | 12
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Osteoporosis 4 | 363
Pick disease 4 | 1,894
astrocytoma 4 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
dermatomyositis 4 | 966
fibroadenoma 4 | 559
megacystis-microcolon-intestinal hypoperistalsis syndrome 4 | 10
pancreatic carcinoma 4 | 562
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
Amyotrophic lateral sclerosis 3 | 451
Animal Mammary Neoplasms 3 | 136
Arthritis, Juvenile 3 | 126
Cardiomegaly 3 | 116
Cardiomyopathy 3 | 116
Coronary artery disease 3 | 268
Esophageal Squamous Cell Carcinoma 3 | 77
Juvenile arthritis 3 | 126
Leukemia, Myelocytic, Acute 3 | 120
Leukemia, Myeloid, Acute 3 | 105
Mammary Neoplasms, Animal 3 | 136
Polycystic ovary syndrome 3 | 360
Primary cutaneous amyloidosis 3 | 29
Proximal muscle weakness 3 | 47
Proximal neurogenic muscle weakness 3 | 47
Skin cancer 3 | 469
Squamous cell carcinoma of esophagus 3 | 77
Waldenstrons macroglobulinemia 3 | 765
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
limb girdle muscular dystrophy 2A 3 | 213
mucosa-associated lymphoid tissue lymphoma 3 | 484
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung carcinoma 3 | 317
pediatric high grade glioma 3 | 1,064
Abdomen distended 2 | 43
Generalized muscle weakness 2 | 57
Gowers sign 2 | 24
Gowers sign present 2 | 24
Neck muscle weakness 2 | 17
Neonatal Hypotonia 2 | 64
Polyhydramnios 2 | 108
Prenatal onset 2 | 139
Reduced fetal movement 2 | 51
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Nervous System 32 | 16,725
Cardiovascular System 31 | 15,192
Respiratory system 31 | 16,393

Target Family

Non-IDG 30 | 12,091
Kinase 3 | 634

Reactome Pathway

Smooth Muscle Contraction 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Myosin regulatory light chain 10 MYL10 Tbio Non-IDG -0.54921 3.64 28
Talin-1 TLN1 Tbio Non-IDG -1.94109 90.0 426
Tripartite motif-containing protein 72 TRIM72 Tbio Non-IDG -1.98480 94.6 146
Paxillin PXN Tbio Non-IDG -2.99437 902.9 1251
Tropomyosin alpha-1 chain TPM1 Tbio Non-IDG -2.19537 154.3 227
Myosin light polypeptide 6 MYL6 Tbio Non-IDG -1.86799 68.9 257
Integrin alpha-1 ITGA1 Tbio Non-IDG -1.97879 88.9 397
Dysferlin DYSF Tbio Non-IDG -2.47585 338.6 210