Development Level

Tbio 8 | 11,445

IMPC Phenotype

abnormal retina morphology 1 | 71
absent spleen 1 | 3
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased grip strength 1 | 41
preweaning lethality, complete... 1 | 979

Disease

psoriasis 7 | 6,694
Carcinoma 6 | 11,493
osteosarcoma 6 | 7,950
Pick disease 5 | 1,894
atypical teratoid / rhabdoid tumor 5 | 5,112
medulloblastoma, large-cell 5 | 6,241
Multiple myeloma 4 | 1,332
lung cancer 4 | 4,740
ovarian cancer 4 | 8,520
Breast cancer 3 | 3,578
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
malignant mesothelioma 3 | 3,232
tuberculosis and treatment for 6 months 3 | 409
Amyotrophic lateral sclerosis 2 | 451
Cancer 2 | 2,499
Schizophrenia 2 | 1,160
acute quadriplegic myopathy 2 | 1,158
ependymoma 2 | 4,679
group 3 medulloblastoma 2 | 4,104
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
primitive neuroectodermal tumor 2 | 3,035
Abnormality of metabolism/homeostasis 1 | 134
Alcoholic Intoxication, Chronic 1 | 289
Alzheimer's disease 1 | 658
Asperger syndrome 1 | 37
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Botulism 1 | 24
Bradykinesia 1 | 34
Chikungunya 1 | 16
Chromosome 18p deletion syndrome 1 | 5
Cocaine-Related Disorders 1 | 92
Congenital heart disease 1 | 93
Craniofacial Abnormalities 1 | 151
Deglutition Disorders 1 | 132
Delayed speech and language development 1 | 112
Disease of mental health 1 | 36
Disseminated intravascular coagulation 1 | 38
Dysarthria 1 | 192
Dystonia 1 | 164
Dystonia Disorders 1 | 6
Dystonia, Limb 1 | 9
Edwards syndrome 1 | 17
Endometrial cancer 1 | 311
Fragile X syndrome 1 | 34
Gaucher disease type 1 1 | 180
Goiter 1 | 38
Granulosa cell tumor 1 | 6
Hyperreflexia 1 | 209
Hypomyelinating leukodystrophy 6 1 | 26
Klinefelter's syndrome 1 | 56
Language Delay 1 | 112
Laryngeal dystonia 1 | 5
Leukemia, Myeloid 1 | 18
Liver cancer 1 | 604
Major Depressive Disorder 1 | 301
Mesothelioma, Malignant 1 | 105
Microsatellite Instability 1 | 12
Mood Disorders 1 | 184
Motor delay 1 | 147
Myeloid Leukemia 1 | 19
No development of motor milestones 1 | 147
Nonorganic psychosis 1 | 84
Oligospermia 1 | 36
Pancytopenia 1 | 45
Papillary thyroid carcinoma 1 | 43
Parkinson's disease 1 | 392
Parkinsonian Disorders 1 | 56
Patau syndrome 1 | 14
Progressive disorder 1 | 142
Psychotic Disorders 1 | 151
Renal Cell Carcinoma 1 | 214
Rhabdomyosarcoma 1 | 39
Seminoma 1 | 15
Shwachman-Diamond syndrome 1 | 17
Speech Delay 1 | 112
Speech impairment 1 | 112
Static Tremor 1 | 21
Turner syndrome 1 | 28
Waterhouse-Friderichsen syndrome 1 | 11
Wilms Tumor 1 | 28
Yellow fever 1 | 16
ovarian neoplasm 1 | 99
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370
tuberculosis 1 | 2,010

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634

Reactome Pathway

Small interfering RNA (siRNA) ... 8 | 8
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Interferon-inducible double-stranded RNA-dependent protein kinase activator A PRKRA Tbio Kinase -1.51727 34.3 299
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
Endoribonuclease Dicer DICER1 Tbio Enzyme -3.34177 2054.3 327
RISC-loading complex subunit TARBP2 TARBP2 Tbio Non-IDG -3.11849 1238.4 273
Protein argonaute-3 AGO3 Tbio Non-IDG -1.30752 14.4 127
Translin-associated protein X TSNAX Tbio Non-IDG -1.84290 72.0 97
Translin TSN Tbio Non-IDG -2.38684 256.2 160