Development Level

Tchem 9 | 1,388
Tbio 8 | 11,651
Tclin 2 | 612

IMPC Phenotype

increased circulating glucose ... 2 | 24
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
decreased circulating iron lev... 1 | 32
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 16 | 11,493
Cancer 13 | 2,499
osteosarcoma 11 | 7,950
psoriasis 11 | 6,694
glioblastoma 9 | 5,792
lung cancer 9 | 4,740
ovarian cancer 9 | 8,520
medulloblastoma, large-cell 8 | 6,241
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
Intellectual disability 6 | 1,016
group 3 medulloblastoma 6 | 4,104
Noonan syndrome 5 | 34
group 4 medulloblastoma 5 | 1,855
malignant mesothelioma 5 | 3,232
Abnormal dermatoglyphic pattern 4 | 24
Blepharoptosis 4 | 231
Byzanthine arch palate 4 | 194
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Conduction disorder of the heart 4 | 79
Congenital pectus carinatum 4 | 52
Cryptorchidism 4 | 296
Curly hair (finding) 4 | 14
Delayed bone age 4 | 136
Downward slant of palpebral fissure 4 | 158
Dull intelligence 4 | 645
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Excess nuchal skin 4 | 30
Full lower lip 4 | 64
Hypoplastic mandible condyle 4 | 275
Joint hyperflexibility 4 | 78
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mandibular hypoplasia 4 | 275
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Micrognathism 4 | 275
Muscle hypotonia 4 | 571
Neck webbing 4 | 35
Neuroblastoma 4 | 80
Orbital separation excessive 4 | 244
Papillary thyroid carcinoma 4 | 43
Poor school performance 4 | 645
Prominent lower lip 4 | 64
Schizophrenia 4 | 1,160
Seizures 4 | 596
Short stature 4 | 531
Stomach Neoplasms 4 | 300
Strabismus 4 | 270
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
juvenile dermatomyositis 4 | 1,187
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Abnormality of pulmonary valve 3 | 23
Abnormality of vision 3 | 40
Alopecia 3 | 115
Asymmetric growth 3 | 5
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Bleeding tendency 3 | 37
Breast Neoplasms 3 | 445
Cerebellar hypoplasia and atrophy 3 | 41
Coarse hair 3 | 31
Colorectal Neoplasms 3 | 243
Decreased projection of midface 3 | 105
Defect of vertebral segmentation 3 | 17
Dental abnormalities 3 | 60
Generalized osteopenia 3 | 99
Generalized overgrowth 3 | 16
Hemangioma 3 | 69
Hemangioma, Cavernous 3 | 20
Horseshoe Kidney 3 | 16
Hypogonadism, Isolated Hypogonadotropic 3 | 71
Hypogonadotropic hypogonadism 3 | 89
Hypopigmentation disorder 3 | 25
Hypotrophic midface 3 | 105
Irregular hyperpigmentation 3 | 33
Kyphoscoliosis deformity of spine 3 | 60
Low posterior hairline 3 | 52
Mammary Neoplasms 3 | 425
Melanocytic nevus 3 | 43
Midface retrusion 3 | 105
Muscle Weakness 3 | 170
Noncancerous mole 3 | 28
Osteopenia 3 | 99
Overgrowth 3 | 16
Prominent back of the head 3 | 21
Pulmonary Stenosis 3 | 45
Pulmonary artery stenosis 3 | 26
Rhabdomyosarcoma 3 | 39
Rough hair texture 3 | 31
Sebaceous adenoma 3 | 26
Small midface 3 | 105
Thyroid cancer 3 | 36
Tooth Abnormalities 3 | 69

Tissue

Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678

Target Family

Kinase 8 | 634
Non-IDG 6 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

Signalling to RAS 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.16502 140.7 702
Ras-related protein Ral-B RALB Tbio Enzyme -1.71078 50.9 228
Ras-related protein Ral-A RALA Tbio Enzyme -2.22188 169.9 225
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Mitogen-activated protein kinase 13 MAPK13 Tchem Kinase -2.63128 394.0 648
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137
Ral guanine nucleotide dissociation stimulator RALGDS Tbio Non-IDG -2.85677 683.6 102
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092