Development Level

Tbio 251 | 10,625
Tchem 143 | 1,890
Tclin 57 | 602
Tdark 17 | 7,003

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 21 | 633
decreased total body fat amoun... 14 | 186
decreased body weight 12 | 174
decreased lean body mass 10 | 195
abnormal behavior 9 | 226
abnormal bone structure 8 | 131
decreased bone mineral content 8 | 157
embryonic lethality prior to t... 8 | 187
preweaning lethality, incomple... 8 | 260
decreased circulating choleste... 7 | 85
increased circulating alkaline... 7 | 119
abnormal embryo size 6 | 112
decreased circulating HDL chol... 6 | 77
decreased lumbar vertebrae num... 6 | 62
enlarged heart 6 | 111
abnormal retina morphology 5 | 100
abnormal retinal pigmentation 5 | 61
decreased body length 5 | 108
decreased circulating LDL chol... 5 | 37
decreased circulating alanine ... 5 | 53
decreased circulating glucose ... 5 | 121
decreased circulating triglyce... 5 | 83
decreased grip strength 5 | 123
abnormal cornea morphology 4 | 24
decreased bone mineral density 4 | 126
decreased circulating serum al... 4 | 79
increased lean body mass 4 | 107
increased mean corpuscular hem... 4 | 93
short tibia 4 | 82
thrombocytopenia 4 | 46
tremors 4 | 34
abnormal gait 3 | 51
abnormal neural tube closure 3 | 37
abnormal vibrissa morphology 3 | 17
decreased T cell number 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating creatini... 3 | 31
decreased circulating fructosa... 3 | 31
decreased circulating sodium l... 3 | 18
decreased circulating total pr... 3 | 41
decreased kidney weight 3 | 7
decreased mean corpuscular vol... 3 | 50
decreased prepulse inhibition 3 | 52
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased bone mineral content 3 | 92
increased circulating HDL chol... 3 | 63
increased circulating LDL chol... 3 | 15
increased circulating free fat... 3 | 17
increased circulating phosphat... 3 | 24
increased leukocyte cell numbe... 3 | 37
increased sacral vertebrae num... 3 | 62
male infertility 3 | 62
abnormal body wall morphology 2 | 7
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal tail morphology 2 | 17
absent pinna reflex 2 | 21
cataract 2 | 26
cleft palate 2 | 6
decreased blood urea nitrogen ... 2 | 31
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating insulin ... 2 | 75
decreased circulating phosphat... 2 | 15
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
decreased mature B cell number 2 | 25
decreased mean corpuscular hem... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
enlarged lymph nodes 2 | 27
impaired pupillary reflex 2 | 14
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased body length 2 | 20
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
convulsive seizures 1 | 11
decreased pulmonary respirator... 1 | 4
female infertility 1 | 34

Disease

osteosarcoma 263 | 7,933
ovarian cancer 262 | 8,484
glioblastoma 207 | 5,572
medulloblastoma, large-cell 207 | 6,234
psoriasis 204 | 6,685
Cancer 183 | 2,346
lung cancer 165 | 4,466
atypical teratoid / rhabdoid tumor 146 | 4,369
pilocytic astrocytoma 119 | 3,086
oligodendroglioma 116 | 2,849
pediatric high grade glioma 115 | 2,712
malignant mesothelioma 110 | 3,162
Breast cancer 109 | 3,094
ependymoma 109 | 2,514
subependymal giant cell astrocytoma 109 | 2,287
Carcinoma 105 | 2,147
primitive neuroectodermal tumor 104 | 3,031
invasive ductal carcinoma 100 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 97 | 3,289
astrocytic glioma 89 | 2,241
lung adenocarcinoma 89 | 2,713
lung carcinoma 86 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 83 | 2,988
non-small cell lung cancer 83 | 2,798
ulcerative colitis 80 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,956
group 4 medulloblastoma 74 | 1,875
interstitial cystitis 72 | 2,299
pancreatic cancer 72 | 2,300
pituitary cancer 70 | 1,972
Pick disease 69 | 1,893
astrocytoma 69 | 1,493
diabetes mellitus 68 | 1,663
group 3 medulloblastoma 67 | 2,254
Multiple myeloma 66 | 1,327
tuberculosis 63 | 1,557
medulloblastoma 62 | 1,524
Rheumatoid Arthritis 59 | 1,160
adult high grade glioma 54 | 2,148
cystic fibrosis 54 | 1,665
ductal carcinoma in situ 54 | 1,745
breast carcinoma 52 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
colon cancer 47 | 1,475
atypical teratoid/rhabdoid tumor 45 | 1,095
Alzheimer's disease 44 | 644
posterior fossa group B ependymoma 42 | 1,530
Schizophrenia 41 | 501
juvenile dermatomyositis 40 | 1,189
posterior fossa group A ependymoma 38 | 1,511
primary pancreatic ductal adenocarcinoma 38 | 1,271
Parkinson's disease 37 | 364
Waldenstrons macroglobulinemia 36 | 765
cutaneous lupus erythematosus 36 | 1,056
dermatomyositis 36 | 933
spina bifida 35 | 1,064
Intellectual disability 34 | 573
Mammary Neoplasms 33 | 410
Prostatic Neoplasms 33 | 471
Vascular disease 33 | 281
acute quadriplegic myopathy 33 | 1,157
adrenocortical carcinoma 33 | 1,427
Obesity 31 | 616
primary Sjogren syndrome 31 | 789
Asthma 29 | 349
gastric carcinoma 29 | 832
pancreatic carcinoma 27 | 567
sonic hedgehog group medulloblastoma 27 | 1,482
non-small cell lung carcinoma 26 | 413
Multiple Sclerosis 25 | 498
Renal Cell Carcinoma 25 | 199
esophageal adenocarcinoma 25 | 737
Down syndrome 24 | 548
Polycystic Ovary Syndrome 24 | 332
non primary Sjogren syndrome sicca 24 | 840
Liver carcinoma 23 | 217
Lung Neoplasms 23 | 171
nasopharyngeal carcinoma 23 | 1,056
progressive supranuclear palsy 23 | 674
gastric cancer 22 | 430
tuberculosis and treatment for 6 months 22 | 686
Amyotrophic Lateral Sclerosis 21 | 431
Autistic Disorder 21 | 320
HIV Infections 21 | 100
Kidney disease 21 | 396
Osteoporosis 21 | 257
Stomach Neoplasms 21 | 282
acute myeloid leukemia 21 | 780
Arthritis 20 | 248
Heart disease 20 | 279
Melanoma 20 | 261
Toxic encephalopathy 20 | 131
mucosa-associated lymphoid tissue lymphoma 20 | 480
Atopic dermatitis 19 | 944
Endometriosis 19 | 535
Neoplasm Invasiveness 19 | 127
active Crohn's disease 19 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 499
Crohn's disease 18 | 304
Duchenne muscular dystrophy 18 | 602

Tissue

Endocrine System 468 | 18,512
Female tissues 468 | 18,647
Nervous System 468 | 18,561
Digestive Tract 467 | 18,473
Liver and Pancreas 466 | 18,136
Urinary Tract 466 | 18,444
Blood and immune system 465 | 17,995
Cardiovascular System 464 | 17,958
Male tissues 463 | 17,969
Skin and soft tissues 463 | 18,115
Respiratory system 457 | 17,484

Target Family

Non-IDG 220 | 11,971
Enzyme 131 | 4,146
Kinase 90 | 634
Transcription Factor 12 | 1,400
Ion Channel 8 | 341
Epigenetic 3 | 242
GPCR 2 | 406
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Signalling by NGF 468 | 468
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
VPS10 domain-containing receptor SorCS3 SORCS3 Tbio Non-IDG -0.54622 5.51 46
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Protein BEX3 BEX3 Tbio Non-IDG -1.87293 81.4 184
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457