Development Level

Tbio 15 | 11,445
Tchem 11 | 1,598
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased total body fat amoun... 3 | 207
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating phosphat... 1 | 27
decreased prepulse inhibition 1 | 82
enlarged heart 1 | 210
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prenatal lethality 1 | 28

Disease

Carcinoma 28 | 11,493
Cancer 23 | 2,499
ovarian cancer 22 | 8,520
osteosarcoma 20 | 7,950
glioblastoma 18 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
Kidney cancer 14 | 2,613
lung cancer 14 | 4,740
Breast cancer 13 | 3,578
psoriasis 13 | 6,694
astrocytic glioma 12 | 2,597
ependymoma 11 | 4,679
Short stature 10 | 531
lung adenocarcinoma 10 | 2,716
medulloblastoma, large-cell 10 | 6,241
pancreatic cancer 10 | 2,398
Blepharoptosis 9 | 231
Byzanthine arch palate 9 | 194
Intellectual disability 9 | 1,016
Muscle hypotonia 9 | 571
Strabismus 9 | 270
Acquired scoliosis 8 | 281
Autosomal recessive predisposition 8 | 1,442
Bleeding tendency 8 | 37
Curvature of spine 8 | 282
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Noonan syndrome 8 | 34
Poor school performance 8 | 645
adult high grade glioma 8 | 3,801
diabetes mellitus 8 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
tuberculosis 8 | 2,010
Abnormal dermatoglyphic pattern 7 | 24
Aortic coarctation 7 | 30
Astrocytoma, Pilocytic 7 | 3,081
Cognitive delay 7 | 608
Cryptorchidism 7 | 296
Downward slant of palpebral fissure 7 | 158
Gastrointestinal Hemorrhage 7 | 52
Global developmental delay 7 | 608
Joint hyperflexibility 7 | 78
Melanoma 7 | 711
Mental and motor retardation 7 | 608
Neck webbing 7 | 35
Orbital separation excessive 7 | 244
Osteoporosis 7 | 363
Renal Cell Carcinoma 7 | 214
Schizophrenia 7 | 1,160
Stomach Neoplasms 7 | 300
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
subependymal giant cell astrocytoma 7 | 2,287
Biparietal narrowing 6 | 28
Cardiomyopathy 6 | 116
Chubby cheeks 6 | 50
Concave bridge of nose 6 | 195
Congenital Epicanthus 6 | 177
Decreased width of the skull 6 | 28
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Electroencephalogram abnormal 6 | 101
Feeding difficulties in infancy 6 | 175
Frontal bossing 6 | 157
Full cheeks 6 | 50
Heart disease 6 | 306
High forehead 6 | 102
Hyperplasia of cheeks 6 | 50
Hypertrophy of cheeks 6 | 50
Hypoplastic mandible condyle 6 | 275
Ichthyoses 6 | 41
Large auricle 6 | 87
Large dysplastic ears 6 | 87
Large pinnae 6 | 87
Large prominent ears 6 | 87
Large protruding ears 6 | 87
Large, floppy ears 6 | 87
Low-set, posteriorly rotated ears 6 | 110
Lung Neoplasms 6 | 232
Macrotia 6 | 87
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Multiple myeloma 6 | 1,332
Neoplasm Invasiveness 6 | 161
Pectus excavatum 6 | 100
Premature Birth 6 | 77
Premature birth of newborn 6 | 67
Puffy cheeks 6 | 50
Short neck 6 | 140
Tall forehead 6 | 102
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
primitive neuroectodermal tumor 6 | 3,035

Tissue

Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192
Nervous System 31 | 16,725

Target Family

Non-IDG 13 | 12,091
Kinase 12 | 634
Enzyme 8 | 4,145

Reactome Pathway

Signaling by high-kinase activ... 33 | 33
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Kinase suppressor of Ras 2 KSR2 Tbio Kinase -0.90433 8.77 280
Fibrinogen alpha chain FGA Tbio Non-IDG -2.88066 753.1 595
Fibrinogen gamma chain FGG Tbio Non-IDG -2.21041 158.7 384