Development Level

Tbio 196 | 10,625
Tchem 63 | 1,890
Tdark 22 | 7,003
Tclin 10 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 8 | 260
decreased body weight 7 | 174
decreased lean body mass 7 | 195
abnormal bone mineralization 5 | 55
decreased bone mineral content 5 | 157
decreased total body fat amoun... 5 | 186
abnormal behavior 4 | 226
decreased startle reflex 4 | 48
increased circulating alkaline... 4 | 119
increased mean corpuscular vol... 4 | 91
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased bone mineral density 3 | 126
decreased circulating fructosa... 3 | 31
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased or absent threshold ... 3 | 128
prenatal lethality prior to he... 3 | 64
abnormal eye morphology 2 | 38
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal respiratory quotient 2 | 9
abnormal testis morphology 2 | 30
corneal opacity 2 | 25
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased total body fat amoun... 2 | 57
kinked tail 2 | 3
male infertility 2 | 62
short tibia 2 | 82
small testis 2 | 37
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 21
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased hemoglobin content 1 | 53
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
small kidney 1 | 10
small superior vagus ganglion 1 | 20
trunk curl 1 | 15

Disease

ovarian cancer 175 | 8,484
psoriasis 131 | 6,685
osteosarcoma 125 | 7,933
glioblastoma 105 | 5,572
lung cancer 98 | 4,466
medulloblastoma, large-cell 97 | 6,234
atypical teratoid / rhabdoid tumor 83 | 4,369
Cancer 82 | 2,346
Breast cancer 78 | 3,094
pilocytic astrocytoma 60 | 3,086
primitive neuroectodermal tumor 60 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,988
malignant mesothelioma 58 | 3,162
Multiple myeloma 57 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
invasive ductal carcinoma 56 | 2,950
lung adenocarcinoma 56 | 2,713
oligodendroglioma 56 | 2,849
subependymal giant cell astrocytoma 54 | 2,287
pediatric high grade glioma 52 | 2,712
lung carcinoma 51 | 2,844
non-small cell lung cancer 51 | 2,798
ependymoma 50 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,956
astrocytic glioma 44 | 2,241
Pick disease 41 | 1,893
breast carcinoma 41 | 1,614
Carcinoma 40 | 2,147
astrocytoma 40 | 1,493
group 4 medulloblastoma 40 | 1,875
interstitial cystitis 39 | 2,299
pituitary cancer 38 | 1,972
pancreatic cancer 37 | 2,300
group 3 medulloblastoma 36 | 2,254
cystic fibrosis 35 | 1,665
ductal carcinoma in situ 34 | 1,745
Waldenstrons macroglobulinemia 29 | 765
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,795
posterior fossa group A ependymoma 29 | 1,511
Rheumatoid Arthritis 28 | 1,160
colon cancer 27 | 1,475
adult high grade glioma 26 | 2,148
primary pancreatic ductal adenocarcinoma 26 | 1,271
ulcerative colitis 26 | 2,087
acute quadriplegic myopathy 25 | 1,157
diabetes mellitus 25 | 1,663
sonic hedgehog group medulloblastoma 25 | 1,482
dermatomyositis 24 | 933
posterior fossa group B ependymoma 23 | 1,530
adrenocortical carcinoma 22 | 1,427
juvenile dermatomyositis 22 | 1,189
medulloblastoma 22 | 1,524
Osteoporosis 20 | 257
cutaneous lupus erythematosus 20 | 1,056
spina bifida 19 | 1,064
acute myeloid leukemia 18 | 780
non primary Sjogren syndrome sicca 18 | 840
tuberculosis 18 | 1,557
Mammary Neoplasms 17 | 410
Obesity 17 | 616
esophageal adenocarcinoma 17 | 737
Intellectual disability 16 | 573
Colorectal Neoplasms 15 | 217
HIV Infections 15 | 100
Alzheimer's disease 14 | 644
Prostatic Neoplasms 14 | 471
Schizophrenia 13 | 501
primary Sjogren syndrome 13 | 789
Duchenne muscular dystrophy 12 | 602
Parkinson's disease 12 | 364
active Crohn's disease 12 | 918
atypical teratoid/rhabdoid tumor 12 | 1,095
nasopharyngeal carcinoma 12 | 1,056
Adenoma 11 | 165
Cleft palate 11 | 125
tuberculosis and treatment for 6 months 11 | 686
Atopic dermatitis 10 | 944
aldosterone-producing adenoma 10 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
non-inflammatory breast cancer 10 | 208
non-small cell lung carcinoma 10 | 413
progressive supranuclear palsy 10 | 674
Colonic Neoplasms 9 | 126
Peripheral Neuropathy 9 | 303
Robinow syndrome 9 | 12
fibroadenoma 9 | 557
Crohn's disease 8 | 304
Lung Neoplasms 8 | 171
Neurodegenerative disease 8 | 383
Squamous cell carcinoma of esophagus 8 | 82
Stomach Neoplasms 8 | 282
gastric carcinoma 8 | 832
ovarian neoplasm 8 | 97
pancreatic carcinoma 8 | 567
sarcoidosis 8 | 358
Down syndrome 7 | 548
Polycystic Ovary Syndrome 7 | 332
gastric cancer 7 | 430
hepatocellular carcinoma 7 | 532
inflammatory breast cancer 7 | 404

Tissue

Female tissues 291 | 18,647
Male tissues 291 | 17,969
Digestive Tract 290 | 18,473
Endocrine System 290 | 18,512
Nervous System 290 | 18,561
Urinary Tract 290 | 18,444
Blood and immune system 289 | 17,995
Liver and Pancreas 288 | 18,136
Cardiovascular System 286 | 17,958
Respiratory system 285 | 17,484
Skin and soft tissues 282 | 18,115

Target Family

Non-IDG 153 | 11,971
Enzyme 78 | 4,146
Kinase 21 | 634
Transcription Factor 16 | 1,400
GPCR 11 | 406
Epigenetic 9 | 242
Ion Channel 3 | 341

Reactome Pathway

Signaling by Wnt 291 | 291
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Frizzled-7 FZD7 Tbio GPCR -1.70812 55.9 303
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103