Development Level

Tbio 196 | 10,625
Tchem 62 | 1,890
Tdark 22 | 7,003
Tclin 10 | 602

Collection

Kinase: IDG Consortium (Targets) 3 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 633
preweaning lethality, incomple... 8 | 260
decreased body weight 7 | 174
decreased lean body mass 7 | 195
abnormal bone mineralization 5 | 55
decreased bone mineral content 5 | 157
decreased total body fat amoun... 5 | 186
abnormal behavior 4 | 226
decreased startle reflex 4 | 48
increased circulating alkaline... 4 | 119
increased mean corpuscular vol... 4 | 91
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased bone mineral density 3 | 126
decreased circulating fructosa... 3 | 31
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased or absent threshold ... 3 | 128
prenatal lethality prior to he... 3 | 64
abnormal eye morphology 2 | 38
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal respiratory quotient 2 | 9
abnormal testis morphology 2 | 30
corneal opacity 2 | 25
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased total body fat amoun... 2 | 57
kinked tail 2 | 3
male infertility 2 | 62
short tibia 2 | 82
small testis 2 | 37
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 21
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased hemoglobin content 1 | 53
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
small kidney 1 | 10
small superior vagus ganglion 1 | 20
trunk curl 1 | 15

Disease

ovarian cancer 174 | 8,491
psoriasis 131 | 6,685
osteosarcoma 125 | 7,933
glioblastoma 105 | 5,572
lung cancer 98 | 4,473
medulloblastoma, large-cell 97 | 6,234
atypical teratoid / rhabdoid tumor 83 | 4,369
Cancer 82 | 2,346
Breast cancer 77 | 3,098
pilocytic astrocytoma 60 | 3,086
primitive neuroectodermal tumor 60 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,988
malignant mesothelioma 58 | 3,163
Multiple myeloma 56 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
invasive ductal carcinoma 56 | 2,950
lung adenocarcinoma 56 | 2,714
oligodendroglioma 56 | 2,849
subependymal giant cell astrocytoma 54 | 2,287
pediatric high grade glioma 52 | 2,712
lung carcinoma 51 | 2,844
non-small cell lung cancer 51 | 2,798
ependymoma 50 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,956
astrocytic glioma 44 | 2,241
Pick disease 41 | 1,893
breast carcinoma 41 | 1,614
Carcinoma 40 | 2,147
astrocytoma 40 | 1,493
group 4 medulloblastoma 40 | 1,875
interstitial cystitis 39 | 2,299
pituitary cancer 38 | 1,972
pancreatic cancer 37 | 2,300
group 3 medulloblastoma 36 | 2,254
cystic fibrosis 35 | 1,670
ductal carcinoma in situ 34 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,795
posterior fossa group A ependymoma 29 | 1,511
Waldenstrons macroglobulinemia 28 | 764
Rheumatoid Arthritis 27 | 1,170
colon cancer 27 | 1,475
adult high grade glioma 26 | 2,148
primary pancreatic ductal adenocarcinoma 26 | 1,271
ulcerative colitis 26 | 2,087
acute quadriplegic myopathy 25 | 1,157
diabetes mellitus 25 | 1,663
sonic hedgehog group medulloblastoma 25 | 1,482
dermatomyositis 23 | 966
posterior fossa group B ependymoma 23 | 1,530
adrenocortical carcinoma 22 | 1,427
juvenile dermatomyositis 22 | 1,189
medulloblastoma 22 | 1,524
Osteoporosis 21 | 259
cutaneous lupus erythematosus 20 | 1,056
acute myeloid leukemia 19 | 785
spina bifida 19 | 1,064
non primary Sjogren syndrome sicca 18 | 840
tuberculosis 18 | 1,563
Mammary Neoplasms 17 | 410
Obesity 17 | 616
esophageal adenocarcinoma 17 | 737
Intellectual disability 16 | 573
Colorectal Neoplasms 15 | 217
Alzheimer's disease 14 | 644
HIV Infections 14 | 99
Prostatic Neoplasms 14 | 471
Schizophrenia 13 | 503
Duchenne muscular dystrophy 12 | 602
Parkinson's disease 12 | 364
active Crohn's disease 12 | 918
atypical teratoid/rhabdoid tumor 12 | 1,095
nasopharyngeal carcinoma 12 | 1,056
primary Sjogren syndrome 12 | 788
Adenoma 11 | 165
Cleft palate 11 | 125
tuberculosis and treatment for 6 months 11 | 686
Atopic dermatitis 10 | 944
aldosterone-producing adenoma 10 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
hepatocellular carcinoma 10 | 550
non-inflammatory breast cancer 10 | 208
non-small cell lung carcinoma 10 | 413
progressive supranuclear palsy 10 | 674
Colonic Neoplasms 9 | 126
Peripheral Neuropathy 9 | 303
Robinow syndrome 9 | 12
fibroadenoma 9 | 557
Crohn's disease 8 | 304
Lung Neoplasms 8 | 171
Neurodegenerative disease 8 | 383
Squamous cell carcinoma of esophagus 8 | 82
Stomach Neoplasms 8 | 282
gastric cancer 8 | 436
gastric carcinoma 8 | 832
ovarian neoplasm 8 | 97
pancreatic carcinoma 8 | 567
sarcoidosis 8 | 368
Down syndrome 7 | 548
chronic lymphocytic leukemia 7 | 244
inflammatory breast cancer 7 | 404

Tissue

Female tissues 290 | 18,646
Male tissues 290 | 17,968
Digestive Tract 289 | 18,472
Endocrine System 289 | 18,511
Nervous System 289 | 18,560
Urinary Tract 289 | 18,443
Blood and immune system 288 | 17,994
Liver and Pancreas 287 | 18,135
Cardiovascular System 285 | 17,957
Respiratory system 284 | 17,483
Skin and soft tissues 281 | 18,114

Target Family

Non-IDG 153 | 11,969
Enzyme 77 | 4,146
Kinase 21 | 634
Transcription Factor 16 | 1,400
GPCR 11 | 408
Epigenetic 9 | 242
Ion Channel 3 | 341

Reactome Pathway

Signaling by Wnt 290 | 290
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
E3 ubiquitin-protein ligase RNF146 RNF146 Tbio Enzyme -0.92024 8.53 46
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Frizzled-1 FZD1 Tbio GPCR -2.04125 74.3 233
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.84344 79.9 342