Development Level

Tbio 223 | 11,445
Tchem 41 | 1,598
Tdark 19 | 6,588
Tclin 10 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 12 | 499
enlarged heart 10 | 210
abnormal heart morphology 8 | 162
decreased vertical activity 7 | 208
abnormal behavior 6 | 298
abnormal embryo size 6 | 220
decreased body weight 6 | 161
embryonic lethality prior to t... 6 | 278
increased mean corpuscular vol... 6 | 92
abnormal bone structure 5 | 187
decreased total body fat amoun... 5 | 207
abnormal eye morphology 4 | 68
abnormal kidney morphology 4 | 65
decreased circulating choleste... 4 | 93
decreased lean body mass 4 | 135
decreased lymphocyte cell numb... 4 | 83
decreased startle reflex 4 | 75
edema 4 | 59
embryonic lethality prior to o... 4 | 239
hyperactivity 4 | 148
increased lean body mass 4 | 172
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal craniofacial morpholo... 3 | 33
abnormal hindbrain morphology 3 | 10
abnormal midbrain morphology 3 | 10
abnormal neural tube closure 3 | 46
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
corneal opacity 3 | 32
decreased bone mineral content 3 | 151
decreased circulating total pr... 3 | 49
embryonic growth retardation 3 | 106
hydrometra 3 | 53
increased circulating choleste... 3 | 66
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
mammalian phenotype 3 | 17
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
thrombocytosis 3 | 27
abnormal cornea morphology 2 | 31
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal iris morphology 2 | 13
abnormal lens morphology 2 | 81
abnormal limb morphology 2 | 13
abnormal locomotor behavior 2 | 24
abnormal pericardium morpholog... 2 | 26
abnormal tail movements 2 | 12
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
cataract 2 | 92
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased total retina thickne... 2 | 17
enlarged spleen 2 | 41
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
kinked tail 2 | 2
male infertility 2 | 123
small testis 2 | 58
syndactyly 2 | 23
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating magnesiu... 1 | 13
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16
trunk curl 1 | 16

Disease

Carcinoma 186 | 11,493
ovarian cancer 175 | 8,520
psoriasis 131 | 6,694
osteosarcoma 124 | 7,950
glioblastoma 111 | 5,792
lung cancer 105 | 4,740
medulloblastoma, large-cell 97 | 6,241
Breast cancer 93 | 3,578
atypical teratoid / rhabdoid tumor 91 | 5,112
Cancer 89 | 2,499
ependymoma 86 | 4,679
group 3 medulloblastoma 67 | 4,104
malignant mesothelioma 62 | 3,232
Astrocytoma, Pilocytic 60 | 3,081
primitive neuroectodermal tumor 60 | 3,035
adult high grade glioma 58 | 3,801
astrocytic glioma 58 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,989
Multiple myeloma 57 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
invasive ductal carcinoma 56 | 2,951
oligodendroglioma 56 | 2,850
lung adenocarcinoma 55 | 2,716
non-small cell lung cancer 54 | 2,890
subependymal giant cell astrocytoma 54 | 2,287
lung carcinoma 51 | 2,843
Kidney cancer 48 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
breast carcinoma 43 | 1,638
pancreatic cancer 43 | 2,398
Pick disease 41 | 1,894
interstitial cystitis 39 | 2,312
pituitary cancer 38 | 1,972
cystic fibrosis 34 | 1,696
ductal carcinoma in situ 34 | 1,745
group 4 medulloblastoma 34 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
Schizophrenia 29 | 1,160
Waldenstrons macroglobulinemia 29 | 765
Intellectual disability 28 | 1,016
Rheumatoid arthritis 28 | 1,191
colon cancer 28 | 1,478
tuberculosis 27 | 2,010
Osteoporosis 26 | 363
astrocytoma 26 | 1,146
diabetes mellitus 26 | 1,728
acute quadriplegic myopathy 25 | 1,158
dermatomyositis 23 | 966
primary pancreatic ductal adenocarcinoma 23 | 1,109
Bipolar Disorder 22 | 666
adrenocortical carcinoma 22 | 1,428
juvenile dermatomyositis 22 | 1,187
ulcerative colitis 22 | 1,819
pediatric high grade glioma 21 | 1,064
Autosomal recessive predisposition 20 | 1,442
cutaneous lupus erythematosus 20 | 1,057
Breast Neoplasms 19 | 445
Obesity 19 | 678
acute myeloid leukemia 19 | 783
spina bifida 19 | 1,074
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
non primary Sjogren syndrome sicca 18 | 891
Cognitive delay 17 | 608
Colorectal Neoplasms 17 | 243
Epilepsy 17 | 792
Global developmental delay 17 | 608
Liver cancer 17 | 604
Mammary Neoplasms 17 | 425
Mental and motor retardation 17 | 608
Short stature 17 | 531
esophageal adenocarcinoma 17 | 737
Cleft Palate 16 | 271
Liver Cirrhosis, Experimental 16 | 769
Prostatic Neoplasms 16 | 495
HIV Infections 15 | 102
Hypoplastic mandible condyle 15 | 275
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Seizures 15 | 596
medulloblastoma 15 | 720
Broad flat nasal bridge 14 | 236
Cryptorchidism 14 | 296
Nasal bridge wide 14 | 236
Congenital hypoplasia of penis 13 | 176
Depressive disorder 13 | 409
Parkinson's disease 13 | 392
Stomach Neoplasms 13 | 300
primary Sjogren syndrome 13 | 735
Adenoma 12 | 167
Alzheimer's disease 12 | 658
Duchenne muscular dystrophy 12 | 601
Orbital separation excessive 12 | 244
Polycystic ovary syndrome 12 | 360
active Crohn's disease 12 | 922
nasopharyngeal carcinoma 12 | 1,058
Muscle hypotonia 11 | 571

Tissue

Endocrine System 290 | 18,159
Digestive Tract 287 | 17,369
Female tissues 286 | 17,400
Blood and immune system 285 | 16,909
Nervous System 285 | 16,725
Male tissues 283 | 17,142
Skin and soft tissues 283 | 17,230
Urinary Tract 279 | 16,678
Liver and Pancreas 277 | 16,750
Respiratory system 276 | 16,393
Cardiovascular System 267 | 15,192

Target Family

Non-IDG 154 | 12,091
Enzyme 78 | 4,145
Kinase 21 | 634
Transcription Factor 17 | 1,400
GPCR 11 | 408
Epigenetic 9 | 242
Ion Channel 3 | 344

Reactome Pathway

Signaling by WNT 293 | 293
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
R-spondin-4 RSPO4 Tbio Non-IDG -1.45244 28.7 66
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261