Development Level

Tbio 76 | 11,445
Tchem 21 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 9 | 499
abnormal embryo size 5 | 220
hypoactivity 4 | 132
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
abnormal behavior 2 | 298
abnormal craniofacial morpholo... 2 | 33
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
female infertility 2 | 60
increased circulating HDL chol... 2 | 80
increased startle reflex 2 | 112
male infertility 2 | 123
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal forebrain morphology 1 | 10
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal placement of pupils 1 | 6
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
anophthalmia 1 | 33
brachydactyly 1 | 19
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged testis 1 | 6
hemorrhage 1 | 23
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 70 | 11,493
ovarian cancer 69 | 8,520
osteosarcoma 51 | 7,950
Cancer 49 | 2,499
glioblastoma 45 | 5,792
psoriasis 42 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
medulloblastoma, large-cell 38 | 6,241
lung cancer 35 | 4,740
ependymoma 33 | 4,679
invasive ductal carcinoma 30 | 2,951
Breast cancer 28 | 3,578
Astrocytoma, Pilocytic 27 | 3,081
malignant mesothelioma 26 | 3,232
adult high grade glioma 25 | 3,801
primitive neuroectodermal tumor 25 | 3,035
lung carcinoma 24 | 2,843
group 3 medulloblastoma 23 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
non-small cell lung cancer 22 | 2,890
pancreatic cancer 22 | 2,398
Pick disease 21 | 1,894
astrocytic glioma 21 | 2,597
oligodendroglioma 21 | 2,850
lung adenocarcinoma 19 | 2,716
pituitary cancer 19 | 1,972
Kidney cancer 18 | 2,613
Multiple myeloma 17 | 1,332
acute quadriplegic myopathy 17 | 1,158
subependymal giant cell astrocytoma 17 | 2,287
tuberculosis 17 | 2,010
group 4 medulloblastoma 16 | 1,855
ductal carcinoma in situ 15 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
acute myeloid leukemia 14 | 783
colon cancer 14 | 1,478
cystic fibrosis 14 | 1,696
juvenile dermatomyositis 14 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
primary pancreatic ductal adenocarcinoma 14 | 1,109
ulcerative colitis 14 | 1,819
astrocytoma 13 | 1,146
interstitial cystitis 13 | 2,312
adrenocortical carcinoma 12 | 1,428
breast carcinoma 12 | 1,638
diabetes mellitus 12 | 1,728
pediatric high grade glioma 12 | 1,064
dermatomyositis 11 | 966
spina bifida 11 | 1,074
Liver Cirrhosis, Experimental 10 | 769
active Crohn's disease 10 | 922
Atopic dermatitis 9 | 952
Duchenne muscular dystrophy 9 | 601
Hypertensive disease 9 | 292
Waldenstrons macroglobulinemia 9 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
Cleft Palate 8 | 271
Fibrodysplasia ossificans progressiva 8 | 17
Prostatic Neoplasms 8 | 495
Ureteral obstruction 8 | 33
medulloblastoma 8 | 720
Craniofacial Abnormalities 7 | 151
Hereditary hemorrhagic telangiectasia 7 | 13
Hypertension 7 | 396
Kidney disease 7 | 430
Orbital separation excessive 7 | 244
Pulmonary Fibrosis 7 | 106
Rheumatoid arthritis 7 | 1,191
Schizophrenia 7 | 1,160
gastric carcinoma 7 | 807
Amyotrophic lateral sclerosis 6 | 451
Anemia 6 | 365
Brachydactyly 6 | 156
Colorectal Neoplasms 6 | 243
Coronary artery disease 6 | 268
Epilepsy 6 | 792
Increase in blood pressure 6 | 119
Seizures 6 | 596
Stomach Neoplasms 6 | 300
aldosterone-producing adenoma 6 | 665
gastric cancer 6 | 459
nasopharyngeal carcinoma 6 | 1,058
progressive supranuclear palsy 6 | 676
Acquired scoliosis 5 | 281
Asthma 5 | 385
Autosomal recessive predisposition 5 | 1,442
Bipolar Disorder 5 | 666
Cerebrovascular disease 5 | 238
Craniosynostosis 5 | 74
Curvature of spine 5 | 282
Endometriosis 5 | 540
Heart disease 5 | 306
Obesity 5 | 678
Short stature 5 | 531
Vascular disease 5 | 319
limb girdle muscular dystrophy 2A 5 | 213
mucosa-associated lymphoid tissue lymphoma 5 | 484
non diabetic and post-ischemic heart failure 5 | 200
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 100 | 18,159
Liver and Pancreas 100 | 16,750
Digestive Tract 99 | 17,369
Skin and soft tissues 99 | 17,230
Female tissues 98 | 17,400
Male tissues 98 | 17,142
Nervous System 97 | 16,725
Cardiovascular System 96 | 15,192
Urinary Tract 96 | 16,678
Blood and immune system 95 | 16,909
Respiratory system 95 | 16,393

Target Family

Non-IDG 44 | 12,091
Enzyme 21 | 4,145
Transcription Factor 20 | 1,400
Kinase 13 | 634
Epigenetic 2 | 242
Transporter 1 | 473

Reactome Pathway

Signaling by TGF-beta family m... 101 | 101
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
E3 ubiquitin-protein ligase TRIM33 TRIM33 Tbio Epigenetic -3.10754 1197.2 297
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Dr1-associated corepressor DRAP1 Tbio Non-IDG -1.11644 10.8 122
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Follistatin-related protein 1 FSTL1 Tbio Non-IDG -1.98038 117.5 265