Development Level

Tbio 53 | 11,445
Tchem 15 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 6 | 499
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
female infertility 2 | 60
increased startle reflex 2 | 112
male infertility 2 | 123
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eyelid morphology 1 | 7
abnormal forebrain morphology 1 | 10
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal placement of pupils 1 | 6
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
brachydactyly 1 | 19
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hemorrhage 1 | 23
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 52 | 8,520
Carcinoma 50 | 11,493
Cancer 41 | 2,499
osteosarcoma 36 | 7,950
glioblastoma 33 | 5,792
lung cancer 29 | 4,740
psoriasis 29 | 6,694
atypical teratoid / rhabdoid tumor 28 | 5,112
medulloblastoma, large-cell 26 | 6,241
ependymoma 22 | 4,679
malignant mesothelioma 22 | 3,232
Astrocytoma, Pilocytic 19 | 3,081
Breast cancer 19 | 3,578
pancreatic cancer 18 | 2,398
primitive neuroectodermal tumor 18 | 3,035
Multiple myeloma 17 | 1,332
adult high grade glioma 17 | 3,801
invasive ductal carcinoma 17 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
lung carcinoma 15 | 2,843
Kidney cancer 14 | 2,613
Pick disease 14 | 1,894
non-small cell lung cancer 14 | 2,890
subependymal giant cell astrocytoma 14 | 2,287
tuberculosis 14 | 2,010
acute quadriplegic myopathy 13 | 1,158
astrocytic glioma 13 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
pituitary cancer 13 | 1,972
oligodendroglioma 12 | 2,850
astrocytoma 11 | 1,146
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung adenocarcinoma 11 | 2,716
primary pancreatic ductal adenocarcinoma 11 | 1,109
acute myeloid leukemia 10 | 783
diabetes mellitus 10 | 1,728
pediatric high grade glioma 10 | 1,064
spina bifida 10 | 1,074
ulcerative colitis 10 | 1,819
Waldenstrons macroglobulinemia 9 | 765
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
Liver Cirrhosis, Experimental 8 | 769
Ureteral obstruction 8 | 33
ductal carcinoma in situ 8 | 1,745
interstitial cystitis 8 | 2,312
Hypertensive disease 7 | 292
Kidney disease 7 | 430
Prostatic Neoplasms 7 | 495
Pulmonary Fibrosis 7 | 106
active Crohn's disease 7 | 922
cystic fibrosis 7 | 1,696
Cleft Palate 6 | 271
Colorectal Neoplasms 6 | 243
Coronary artery disease 6 | 268
Orbital separation excessive 6 | 244
medulloblastoma 6 | 720
Acquired scoliosis 5 | 281
Asthma 5 | 385
Bipolar Disorder 5 | 666
Cerebrovascular disease 5 | 238
Craniofacial Abnormalities 5 | 151
Curvature of spine 5 | 282
Epilepsy 5 | 792
Hypertension 5 | 396
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
Seizures 5 | 596
gastric cancer 5 | 459
gastric carcinoma 5 | 807
progressive supranuclear palsy 5 | 676
Adenoma 4 | 167
Anemia 4 | 365
Atherosclerosis 4 | 291
Atopic dermatitis 4 | 952
Duchenne muscular dystrophy 4 | 601
Heart disease 4 | 306
Hypoplastic mandible condyle 4 | 275
Liver disease 4 | 237
Lung Neoplasms 4 | 232
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Neurodegenerative disease 4 | 414
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Peripheral T-cell lymphoma 4 | 25
Pneumonia 4 | 174
Squamous cell carcinoma 4 | 129
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
non diabetic and post-ischemic heart failure 4 | 200
primary Sjogren syndrome 4 | 735

Tissue

Cardiovascular System 72 | 15,192
Digestive Tract 72 | 17,369
Endocrine System 72 | 18,159
Liver and Pancreas 72 | 16,750
Male tissues 72 | 17,142
Nervous System 72 | 16,725
Skin and soft tissues 72 | 17,230
Blood and immune system 71 | 16,909
Female tissues 71 | 17,400
Respiratory system 71 | 16,393
Urinary Tract 71 | 16,678

Target Family

Non-IDG 28 | 12,091
Enzyme 21 | 4,145
Transcription Factor 15 | 1,400
Kinase 5 | 634
Epigenetic 2 | 242
Transporter 1 | 473

Reactome Pathway

Signaling by TGF-beta Receptor... 72 | 72
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
E3 ubiquitin-protein ligase TRIM33 TRIM33 Tbio Epigenetic -3.10754 1197.2 297
Myotubularin-related protein 4 MTMR4 Tbio Enzyme -0.76288 7.50 138
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Menin MEN1 Tchem Non-IDG -3.23460 1803.0 382
Protein TMEPAI PMEPA1 Tbio Non-IDG -1.35527 24.8 90