Development Level

Tbio 52 | 10,625
Tchem 17 | 1,890
Tclin 3 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 8 | 633
decreased lean body mass 6 | 195
preweaning lethality, incomple... 5 | 260
increased or absent threshold ... 4 | 128
abnormal retina morphology 3 | 100
decreased bone mineral content 3 | 157
hypoactivity 3 | 89
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
decreased grip strength 2 | 123
decreased rib number 2 | 59
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
abnormal QRS complex 1 | 25
abnormal craniofacial morpholo... 1 | 12
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal forebrain morphology 1 | 4
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal tail morphology 1 | 17
abnormal vibrissa morphology 1 | 17
absent startle reflex 1 | 15
brachydactyly 1 | 2
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
cyanosis 1 | 6
decreased body length 1 | 108
decreased circulating calcium ... 1 | 33
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
enlarged epididymis 1 | 27
enlarged heart 1 | 111
hemorrhage 1 | 12
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased CD8-positive, naive ... 1 | 3
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 52 | 8,484
Cancer 38 | 2,346
osteosarcoma 36 | 7,933
glioblastoma 32 | 5,572
psoriasis 29 | 6,685
lung cancer 27 | 4,466
medulloblastoma, large-cell 26 | 6,234
atypical teratoid / rhabdoid tumor 24 | 4,369
pediatric high grade glioma 21 | 2,712
malignant mesothelioma 20 | 3,162
pilocytic astrocytoma 19 | 3,086
primitive neuroectodermal tumor 18 | 3,031
Breast cancer 17 | 3,094
Multiple myeloma 17 | 1,327
invasive ductal carcinoma 17 | 2,950
Carcinoma 16 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
pancreatic cancer 16 | 2,300
astrocytoma 15 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
lung carcinoma 15 | 2,844
Pick disease 14 | 1,893
non-small cell lung cancer 14 | 2,798
subependymal giant cell astrocytoma 14 | 2,287
acute quadriplegic myopathy 13 | 1,157
ependymoma 13 | 2,514
group 4 medulloblastoma 13 | 1,875
pituitary cancer 13 | 1,972
oligodendroglioma 12 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
primary pancreatic ductal adenocarcinoma 12 | 1,271
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
lung adenocarcinoma 11 | 2,713
tuberculosis 11 | 1,557
ulcerative colitis 11 | 2,087
spina bifida 10 | 1,064
Waldenstrons macroglobulinemia 9 | 765
acute myeloid leukemia 9 | 780
adrenocortical carcinoma 9 | 1,427
astrocytic glioma 9 | 2,241
colon cancer 9 | 1,475
dermatomyositis 9 | 933
diabetes mellitus 9 | 1,663
juvenile dermatomyositis 9 | 1,189
Kidney disease 8 | 396
ductal carcinoma in situ 8 | 1,745
interstitial cystitis 8 | 2,299
Ureteral disease 7 | 23
active Crohn's disease 7 | 918
cystic fibrosis 7 | 1,665
group 3 medulloblastoma 7 | 2,254
medulloblastoma 7 | 1,524
sonic hedgehog group medulloblastoma 7 | 1,482
Prostatic Neoplasms 6 | 471
Pulmonary Fibrosis 6 | 66
adult high grade glioma 6 | 2,148
gastric carcinoma 6 | 832
posterior fossa group A ependymoma 6 | 1,511
Adenoma 5 | 165
Aortic aneurysm 5 | 34
Colorectal Neoplasms 5 | 217
Craniofacial Abnormalities 5 | 147
Hypertension 5 | 287
IGA Glomerulonephritis 5 | 454
Rheumatoid Arthritis 5 | 1,160
inflammatory breast cancer 5 | 404
progressive supranuclear palsy 5 | 674
Asthma 4 | 349
Atherosclerosis 4 | 275
Atopic dermatitis 4 | 944
Cerebrovascular disease 4 | 231
Cleft palate 4 | 125
Duchenne muscular dystrophy 4 | 602
Endometriosis 4 | 535
Heart disease 4 | 279
Liver Cirrhosis, Experimental 4 | 108
Liver disease 4 | 219
Loeys-Dietz syndrome 4 | 23
Lung Neoplasms 4 | 171
Neoplasm Invasiveness 4 | 127
Neoplasm Metastasis 4 | 138
Neurodegenerative disease 4 | 383
Obesity 4 | 616
Peripheral T-cell lymphoma 4 | 24
Pneumonia 4 | 133
Stomach Neoplasms 4 | 282
aldosterone-producing adenoma 4 | 664
atypical teratoid/rhabdoid tumor 4 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
gastric cancer 4 | 430
non diabetic and post-ischemic heart failure 4 | 200
posterior fossa group B ependymoma 4 | 1,530
primary Sjogren syndrome 4 | 789
Alzheimer's disease 3 | 644
Proliferative vitreoretinopathy 3 | 17
Vascular disease 3 | 281
chronic lymphosyte leukemia 3 | 232
mucosa-associated lymphoid tissue lymphoma 3 | 480
nasopharyngeal carcinoma 3 | 1,056
pancreatic carcinoma 3 | 567

Tissue

Blood and immune system 73 | 17,995
Cardiovascular System 73 | 17,958
Digestive Tract 73 | 18,473
Endocrine System 73 | 18,512
Female tissues 73 | 18,647
Liver and Pancreas 73 | 18,136
Male tissues 73 | 17,969
Nervous System 73 | 18,561
Skin and soft tissues 73 | 18,115
Urinary Tract 73 | 18,444
Respiratory system 72 | 17,484

Target Family

Non-IDG 29 | 11,971
Enzyme 21 | 4,146
Transcription Factor 15 | 1,400
Kinase 5 | 634
Epigenetic 2 | 242
Transporter 1 | 473

Reactome Pathway

Signaling by TGF-beta Receptor... 73 | 73
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.79254 69.5 187
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.75744 370.6 255
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.03840 1043.2 1391
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Ubiquitin-conjugating enzyme E2 D3 UBE2D3 Tbio Non-IDG -1.23367 18.0 133
NEDD8-conjugating enzyme Ubc12 UBE2M Tbio Non-IDG -1.23759 14.6 104
Mothers against decapentaplegic homolog 7 SMAD7 Tbio Transcription Factor -2.67244 485.2 380