Development Level

Tbio 22 | 10,625
Tchem 8 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 3 | 125

IMPC Phenotype

decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating iron lev... 2 | 25
abnormal bone structure 1 | 131
abnormal locomotor activation 1 | 26
cataract 1 | 26
decreased circulating fructosa... 1 | 31
decreased circulating triglyce... 1 | 83
decreased lean body mass 1 | 195
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
fused cornea and lens 1 | 4
increased blood urea nitrogen ... 1 | 44
increased circulating amylase ... 1 | 13
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
oligodactyly 1 | 14
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 25 | 8,491
osteosarcoma 21 | 7,933
glioblastoma 19 | 5,572
medulloblastoma, large-cell 15 | 6,234
atypical teratoid / rhabdoid tumor 14 | 4,369
Breast cancer 12 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
pilocytic astrocytoma 12 | 3,086
psoriasis 12 | 6,685
Carcinoma 11 | 2,147
lung cancer 11 | 4,473
oligodendroglioma 11 | 2,849
pediatric high grade glioma 11 | 2,712
Cancer 10 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
astrocytic glioma 9 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
lung carcinoma 9 | 2,844
pancreatic cancer 9 | 2,300
ependymoma 8 | 2,514
invasive ductal carcinoma 8 | 2,950
non-small cell lung cancer 8 | 2,798
primary pancreatic ductal adenocarcinoma 8 | 1,271
primitive neuroectodermal tumor 8 | 3,031
Pick disease 7 | 1,893
group 4 medulloblastoma 7 | 1,875
malignant mesothelioma 7 | 3,163
medulloblastoma 7 | 1,524
subependymal giant cell astrocytoma 7 | 2,287
cystic fibrosis 6 | 1,670
pituitary cancer 6 | 1,972
Schizophrenia 5 | 503
Waldenstrons macroglobulinemia 5 | 764
adult high grade glioma 5 | 2,148
group 3 medulloblastoma 5 | 2,254
interstitial cystitis 5 | 2,299
posterior fossa group A ependymoma 5 | 1,511
Intellectual disability 4 | 573
Multiple myeloma 4 | 1,327
Proteinuria 4 | 63
astrocytoma 4 | 1,493
breast carcinoma 4 | 1,614
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,189
tuberculosis 4 | 1,563
ulcerative colitis 4 | 2,087
Autistic Disorder 3 | 320
Gastrointestinal stromal tumor 3 | 61
Mammary Neoplasms 3 | 410
acute quadriplegic myopathy 3 | 1,157
colon cancer 3 | 1,475
hereditary spastic paraplegia 3 | 313
interstitial lung disease 3 | 292
lung adenocarcinoma 3 | 2,714
sonic hedgehog group medulloblastoma 3 | 1,482
3p- syndrome 2 | 21
Adenocarcinoma 2 | 115
Albuminuria 2 | 20
Atopic dermatitis 2 | 944
Becker muscular dystrophy 2 | 187
Blastic phase chronic myeloid leukemia 2 | 58
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic eosinophilic leukemia 2 | 11
Chronic phase chronic myeloid leukemia 2 | 45
Clostridium difficile colitis 2 | 12
Dermatofibrosarcoma protuberans 2 | 16
Down syndrome 2 | 548
Gaucher disease type 1 2 | 171
Gingival fibromatosis 2 | 13
Idiopathic hypereosinophilic syndrome 2 | 10
LEOPARD Syndrome 2 | 20
Liver Cirrhosis 2 | 101
Liver carcinoma 2 | 217
Myelodysplastic/ Myeloproliferative Diseases associated with Platelet-derived Growth Factor Receptor 2 | 9
Nephrotic Syndrome 2 | 48
Noonan Syndrome 2 | 33
Parkinson's disease 2 | 364
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Renal Cell Carcinoma 2 | 199
Rheumatoid Arthritis 2 | 1,170
Systemic mast cell disease 2 | 12
Vesicoureteral reflux 2 | 28
Wiskott-Aldrich syndrome 2 | 27
active Crohn's disease 2 | 918
atypical teratoid/rhabdoid tumor 2 | 1,095
chronic rhinosinusitis 2 | 512
cutaneous lupus erythematosus 2 | 1,056
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,663
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 550
non primary Sjogren syndrome sicca 2 | 840
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 788
tuberculosis and treatment for 6 months 2 | 686
HIV Infections 1 | 99
Hepatitis C 1 | 90
Portal hypertension 1 | 21
Squamous cell carcinoma of esophagus 1 | 82

Tissue

Blood and immune system 32 | 17,994
Cardiovascular System 32 | 17,957
Digestive Tract 32 | 18,472
Endocrine System 32 | 18,511
Female tissues 32 | 18,646
Liver and Pancreas 32 | 18,135
Male tissues 32 | 17,968
Nervous System 32 | 18,560
Respiratory system 32 | 17,483
Urinary Tract 32 | 18,443
Skin and soft tissues 31 | 18,114

Target Family

Non-IDG 16 | 11,969
Enzyme 8 | 4,146
Kinase 8 | 634

Reactome Pathway

Signaling by Robo receptor 32 | 32
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SLIT-ROBO Rho GTPase-activating protein 3 SRGAP3 Tbio Enzyme -1.65005 52.7 69
Cytoplasmic protein NCK2 NCK2 Tbio Non-IDG -1.56739 34.8 215
Slit homolog 2 protein SLIT2 Tbio Non-IDG -1.99206 97.7 195
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.27458 228.6 993
Serine/threonine-protein kinase PAK 2 PAK2 Tchem Kinase -1.88019 81.4 574
Serine/threonine-protein kinase PAK 6 PAK6 Tchem Kinase -1.53195 40.4 368
Serine/threonine-protein kinase PAK 3 PAK3 Tchem Kinase -1.33193 20.3 334
CLIP-associating protein 1 CLASP1 Tbio Non-IDG -1.21948 16.2 184
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.49571 3222.2 1533