Development Level

Tbio 298 | 11,651
Tchem 42 | 1,388
Tdark 37 | 6,593
Tclin 9 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 9 | 298
embryonic lethality prior to t... 8 | 278
abnormal embryo size 7 | 220
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
cataract 6 | 92
decreased circulating serum al... 6 | 82
decreased grip strength 6 | 116
embryonic lethality prior to o... 6 | 239
hypoactivity 6 | 132
edema 5 | 59
embryonic growth retardation 5 | 106
increased mean corpuscular vol... 5 | 92
short tibia 5 | 97
abnormal bone structure 4 | 187
abnormal retina morphology 4 | 71
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased circulating iron lev... 4 | 32
improved glucose tolerance 4 | 79
increased blood urea nitrogen ... 4 | 48
increased circulating alkaline... 4 | 122
increased fasted circulating g... 4 | 76
increased lean body mass 4 | 172
increased startle reflex 4 | 112
prenatal lethality prior to he... 4 | 87
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
abnormal skin coloration 3 | 25
decreased blood urea nitrogen ... 3 | 51
decreased circulating LDL chol... 3 | 38
decreased circulating free fat... 3 | 31
decreased circulating fructosa... 3 | 30
decreased circulating triglyce... 3 | 79
decreased heart left ventricle... 3 | 28
decreased hematocrit 3 | 46
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
hyperactivity 3 | 148
increased circulating HDL chol... 3 | 80
increased total body fat amoun... 3 | 134
microphthalmia 3 | 26
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal heart morphology 2 | 162
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased threshold for audito... 2 | 26
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
long tibia 2 | 25
male infertility 2 | 123
pallor 2 | 34
prolonged PR interval 2 | 15
tremors 2 | 39
abnormal craniofacial morpholo... 1 | 33
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
vertebral fusion 1 | 23

Disease

Carcinoma 273 | 11,493
ovarian cancer 237 | 8,520
osteosarcoma 211 | 7,950
glioblastoma 194 | 5,792
medulloblastoma, large-cell 191 | 6,241
atypical teratoid / rhabdoid tumor 178 | 5,112
psoriasis 176 | 6,694
lung cancer 156 | 4,740
Breast cancer 136 | 3,578
adult high grade glioma 132 | 3,801
group 3 medulloblastoma 129 | 4,104
primitive neuroectodermal tumor 125 | 3,035
ependymoma 124 | 4,679
non-small cell lung cancer 119 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 116 | 3,291
invasive ductal carcinoma 114 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 109 | 2,989
lung adenocarcinoma 103 | 2,716
Kidney cancer 101 | 2,613
malignant mesothelioma 97 | 3,232
Cancer 91 | 2,499
Astrocytoma, Pilocytic 89 | 3,081
subependymal giant cell astrocytoma 82 | 2,287
pancreatic cancer 80 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,955
lung carcinoma 74 | 2,843
oligodendroglioma 74 | 2,850
breast carcinoma 72 | 1,638
ductal carcinoma in situ 69 | 1,745
astrocytic glioma 66 | 2,597
group 4 medulloblastoma 59 | 1,855
adrenocortical carcinoma 58 | 1,428
Pick disease 56 | 1,894
ulcerative colitis 56 | 1,819
colon cancer 54 | 1,478
interstitial cystitis 54 | 2,312
cystic fibrosis 47 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
pituitary cancer 43 | 1,972
tuberculosis 42 | 2,010
Multiple myeloma 40 | 1,332
Intellectual disability 39 | 1,016
Waldenstrons macroglobulinemia 39 | 765
Endometriosis 37 | 540
juvenile dermatomyositis 37 | 1,187
acute quadriplegic myopathy 36 | 1,158
cutaneous lupus erythematosus 35 | 1,057
dermatomyositis 35 | 966
pediatric high grade glioma 35 | 1,064
nasopharyngeal carcinoma 34 | 1,058
Atopic dermatitis 33 | 952
Rheumatoid arthritis 33 | 1,191
Schizophrenia 33 | 1,160
astrocytoma 33 | 1,146
spina bifida 33 | 1,074
diabetes mellitus 30 | 1,728
primary Sjogren syndrome 30 | 735
primary pancreatic ductal adenocarcinoma 28 | 1,109
Liver Cirrhosis, Experimental 27 | 769
medulloblastoma 27 | 720
Breast Neoplasms 22 | 445
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Poor school performance 22 | 645
Liver cancer 20 | 604
Mammary Neoplasms 20 | 425
gastric carcinoma 20 | 807
Cognitive delay 19 | 608
Epilepsy 19 | 792
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
active Crohn's disease 19 | 922
Alzheimer's disease 18 | 658
Seizures 17 | 596
Short stature 17 | 531
Small head 17 | 374
aldosterone-producing adenoma 17 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 510
hepatocellular carcinoma 17 | 547
hereditary spastic paraplegia 17 | 318
pancreatic carcinoma 17 | 562
progressive supranuclear palsy 17 | 676
Bipolar Disorder 16 | 666
Duchenne muscular dystrophy 16 | 601
esophageal adenocarcinoma 16 | 737
gastric cancer 16 | 459
Melanoma 15 | 711
Prostatic Neoplasms 15 | 495
acute myeloid leukemia 15 | 783
Amyotrophic lateral sclerosis 14 | 451
Autosomal recessive predisposition 14 | 1,442
Endometrial cancer 14 | 311
Neoplasm Invasiveness 14 | 161
Skin cancer 14 | 469
non primary Sjogren syndrome sicca 14 | 891
Hypertension 13 | 396
Orbital separation excessive 13 | 244
mucosa-associated lymphoid tissue lymphoma 13 | 484

Tissue

Endocrine System 384 | 18,159
Digestive Tract 381 | 17,369
Female tissues 381 | 17,400
Skin and soft tissues 380 | 17,230
Blood and immune system 379 | 16,909
Liver and Pancreas 379 | 16,750
Male tissues 379 | 17,142
Nervous System 378 | 16,725
Respiratory system 378 | 16,393
Urinary Tract 378 | 16,678
Cardiovascular System 365 | 15,192

Target Family

Non-IDG 259 | 12,091
Enzyme 92 | 4,145
Kinase 29 | 634
Epigenetic 2 | 242
Ion Channel 2 | 344
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by Rho GTPases 386 | 386
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Rho guanine nucleotide exchange factor 38 ARHGEF38 Tdark Non-IDG 0.85 0.14 8
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249