Development Level

Tbio 269 | 10,625
Tchem 57 | 1,890
Tdark 43 | 7,003
Tclin 9 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 22 | 633
preweaning lethality, incomple... 10 | 260
decreased body weight 9 | 174
abnormal behavior 7 | 226
abnormal retina morphology 7 | 100
decreased total body fat amoun... 7 | 186
embryonic lethality prior to t... 6 | 187
decreased bone mineral content 5 | 157
decreased circulating iron lev... 5 | 25
decreased grip strength 5 | 123
decreased lean body mass 5 | 195
improved glucose tolerance 5 | 56
increased fasted circulating g... 5 | 68
abnormal embryo size 4 | 112
abnormal retinal pigmentation 4 | 61
decreased circulating fructosa... 4 | 31
decreased circulating serum al... 4 | 79
embryonic lethality prior to o... 4 | 148
increased blood urea nitrogen ... 4 | 44
increased circulating alkaline... 4 | 119
abnormal coat/hair pigmentatio... 3 | 54
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating free fat... 3 | 39
decreased circulating insulin ... 3 | 75
decreased circulating triglyce... 3 | 83
decreased hematocrit 3 | 25
decreased leukocyte cell numbe... 3 | 54
hypoactivity 3 | 89
increased circulating calcium ... 3 | 32
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal lens morphology 2 | 73
abnormal placenta size 2 | 10
abnormal skin coloration 2 | 18
decreased T cell number 2 | 31
decreased circulating aspartat... 2 | 27
decreased circulating bilirubi... 2 | 14
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased hemoglobin content 2 | 53
decreased mature B cell number 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
embryonic growth retardation 2 | 28
enlarged lymph nodes 2 | 27
hydrops fetalis 2 | 22
hyperactivity 2 | 108
impaired righting response 2 | 19
increased B cell number 2 | 23
increased CD4-positive, alpha ... 2 | 15
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased circulating phosphat... 2 | 24
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal locomotor activation 1 | 26
abnormal placenta morphology 1 | 4
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
decreased CD8-positive, alpha-... 1 | 26
decreased IgG1 level 1 | 4
decreased NK cell number 1 | 16
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
hemorrhage 1 | 12
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating glucose ... 1 | 16
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
long tibia 1 | 13
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
small kidney 1 | 10
stereotypic behavior 1 | 3
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 232 | 8,484
osteosarcoma 205 | 7,933
medulloblastoma, large-cell 187 | 6,234
glioblastoma 185 | 5,572
psoriasis 174 | 6,685
lung cancer 147 | 4,466
atypical teratoid / rhabdoid tumor 144 | 4,369
primitive neuroectodermal tumor 123 | 3,031
Breast cancer 120 | 3,094
non-small cell lung cancer 116 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 115 | 3,289
invasive ductal carcinoma 112 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 108 | 2,988
lung adenocarcinoma 104 | 2,713
pediatric high grade glioma 103 | 2,712
malignant mesothelioma 93 | 3,162
Cancer 90 | 2,346
Carcinoma 88 | 2,147
pilocytic astrocytoma 88 | 3,086
subependymal giant cell astrocytoma 81 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,956
pancreatic cancer 75 | 2,300
lung carcinoma 74 | 2,844
oligodendroglioma 74 | 2,849
group 3 medulloblastoma 73 | 2,254
breast carcinoma 68 | 1,614
ductal carcinoma in situ 68 | 1,745
ependymoma 67 | 2,514
ulcerative colitis 64 | 2,087
adult high grade glioma 61 | 2,148
astrocytic glioma 57 | 2,241
adrenocortical carcinoma 55 | 1,427
Pick disease 54 | 1,893
colon cancer 54 | 1,475
interstitial cystitis 54 | 2,299
group 4 medulloblastoma 52 | 1,875
medulloblastoma 50 | 1,524
sonic hedgehog group medulloblastoma 48 | 1,482
cystic fibrosis 46 | 1,665
posterior fossa group A ependymoma 44 | 1,511
pituitary cancer 43 | 1,972
astrocytoma 40 | 1,493
Multiple myeloma 39 | 1,327
Waldenstrons macroglobulinemia 38 | 765
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
Endometriosis 35 | 535
IGA Glomerulonephritis 35 | 454
atypical teratoid/rhabdoid tumor 35 | 1,095
dermatomyositis 35 | 933
primary pancreatic ductal adenocarcinoma 35 | 1,271
acute quadriplegic myopathy 34 | 1,157
cutaneous lupus erythematosus 34 | 1,056
primary Sjogren syndrome 34 | 789
juvenile dermatomyositis 33 | 1,189
nasopharyngeal carcinoma 33 | 1,056
tuberculosis 33 | 1,557
Rheumatoid Arthritis 32 | 1,160
spina bifida 32 | 1,064
Atopic dermatitis 31 | 944
diabetes mellitus 28 | 1,663
posterior fossa group B ependymoma 26 | 1,530
Intellectual disability 25 | 573
gastric carcinoma 21 | 832
active Crohn's disease 19 | 918
Mammary Neoplasms 18 | 410
aldosterone-producing adenoma 17 | 664
esophageal adenocarcinoma 17 | 737
hereditary spastic paraplegia 17 | 313
pancreatic carcinoma 17 | 567
progressive supranuclear palsy 17 | 674
tuberculosis and treatment for 6 months 17 | 686
Alzheimer's disease 16 | 644
Duchenne muscular dystrophy 16 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 499
gastric cancer 16 | 430
Kidney disease 14 | 396
Prostatic Neoplasms 14 | 471
acute myeloid leukemia 14 | 780
hepatocellular carcinoma 14 | 532
inflammatory breast cancer 14 | 404
non-small cell lung carcinoma 14 | 413
Amyotrophic Lateral Sclerosis 13 | 431
Down syndrome 13 | 548
mucosa-associated lymphoid tissue lymphoma 13 | 480
Schizophrenia 12 | 501
Liver carcinoma 11 | 217
Neoplasm Invasiveness 11 | 127
Polycystic Ovary Syndrome 11 | 332
Vascular disease 10 | 281
Wiskott-Aldrich syndrome 10 | 27
fibroadenoma 10 | 557
non primary Sjogren syndrome sicca 10 | 840
Colorectal Neoplasms 9 | 217
Crohn's disease 9 | 304
Hypertension 9 | 287
Neurodegenerative disease 9 | 383
Neuropathy 9 | 210
Stomach Neoplasms 9 | 282
glioblastoma multiforme 9 | 347
interstitial lung disease 9 | 291

Tissue

Digestive Tract 377 | 18,473
Female tissues 377 | 18,647
Male tissues 377 | 17,969
Nervous System 377 | 18,561
Blood and immune system 376 | 17,995
Endocrine System 376 | 18,512
Liver and Pancreas 376 | 18,136
Cardiovascular System 375 | 17,958
Urinary Tract 375 | 18,444
Respiratory system 373 | 17,484
Skin and soft tissues 366 | 18,115

Target Family

Non-IDG 251 | 11,971
Enzyme 92 | 4,146
Kinase 29 | 634
Epigenetic 2 | 242
Ion Channel 2 | 341
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by Rho GTPases 378 | 378
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.68837 532.8 347