Development Level

Tbio 24 | 11,651
Tchem 10 | 1,388
Tclin 7 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal ovary morphology 1 | 7
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased circulating aspartat... 1 | 34
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
enlarged ovary 1 | 2
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
persistence of hyaloid vascula... 1 | 33
small testis 1 | 58

Disease

Carcinoma 27 | 11,493
psoriasis 21 | 6,694
osteosarcoma 19 | 7,950
ovarian cancer 19 | 8,520
medulloblastoma, large-cell 17 | 6,241
glioblastoma 15 | 5,792
Cancer 13 | 2,499
lung cancer 13 | 4,740
pituitary cancer 13 | 1,972
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
ductal carcinoma in situ 10 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
atypical teratoid / rhabdoid tumor 9 | 5,112
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
breast carcinoma 8 | 1,638
fibroadenoma 8 | 559
interstitial cystitis 8 | 2,312
non-small cell lung cancer 8 | 2,890
oligodendroglioma 8 | 2,850
Autosomal recessive predisposition 7 | 1,442
Breast cancer 7 | 3,578
Kaposi's Sarcoma Skin Lesions 7 | 8
Liver Cirrhosis, Experimental 7 | 769
Obesity 7 | 678
active Crohn's disease 7 | 922
astrocytic glioma 7 | 2,597
lung adenocarcinoma 7 | 2,716
Leigh disease 6 | 100
Myocardial Ischemia 6 | 169
Schizophrenia 6 | 1,160
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
nasopharyngeal carcinoma 6 | 1,058
spina bifida 6 | 1,074
subependymal giant cell astrocytoma 6 | 2,287
Acidosis, Lactic 5 | 97
Cognitive delay 5 | 608
Endometriosis 5 | 540
Global developmental delay 5 | 608
Kidney cancer 5 | 2,613
Mental and motor retardation 5 | 608
Stomach Neoplasms 5 | 300
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pancreatic cancer 5 | 2,398
Acne vulgaris 4 | 15
Acute promyelocytic leukemia, FAB M3 4 | 11
Alcoholic Intoxication, Chronic 4 | 289
Atopic dermatitis 4 | 952
Breast Neoplasms 4 | 445
Chloasma 4 | 6
Epilepsy 4 | 792
Facial Fine Wrinkling 4 | 5
Fine Wrinkling 4 | 5
Hyperkeratosis 4 | 50
Lactic acidemia 4 | 95
Lactic acidosis 4 | 51
Mammary Neoplasms 4 | 425
Mottle Hyperpigmentation 4 | 5
Multiple myeloma 4 | 1,332
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Pyruvate decarboxylase deficiency 4 | 16
Seizures 4 | 596
Severe Recalcitrant Nodular Acne 4 | 5
Small head 4 | 374
Solar Lentigines 4 | 6
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
group 4 medulloblastoma 4 | 1,855
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Dystonia 3 | 164
Dystonic disease 3 | 106
Liver disease 3 | 237
Osteoarthritis 3 | 184
Primary cutaneous T-cell lymphoma 3 | 29
acute myeloid leukemia 3 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
chronic rhinosinusitis 3 | 512
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
gastric cancer 3 | 459
hereditary spastic paraplegia 3 | 318
juvenile dermatomyositis 3 | 1,187
mucosa-associated lymphoid tissue lymphoma 3 | 484
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Endocrine System 42 | 18,159
Blood and immune system 41 | 16,909
Digestive Tract 40 | 17,369
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Cardiovascular System 37 | 15,192

Target Family

Enzyme 26 | 4,145
Nuclear Receptor 7 | 48
Non-IDG 5 | 12,091
Kinase 4 | 634

Reactome Pathway

Signaling by Retinoic Acid 42 | 42
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial PDHA2 Tbio Enzyme -1.11924 13.9 89
Carnitine O-palmitoyltransferase 1, liver isoform CPT1A Tchem Enzyme -2.38489 225.0 306
Dehydrogenase/reductase SDR family member 4 DHRS4 Tbio Enzyme -1.65486 46.6 122
Retinoic acid receptor gamma RARG Tclin Nuclear Receptor -2.13866 127.0 126
Alcohol dehydrogenase 1C ADH1C Tclin Enzyme -2.42307 381.5 97
Retinoic acid receptor RXR-gamma RXRG Tclin Nuclear Receptor -1.67082 42.0 281
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB Tbio Enzyme -1.71672 48.4 149
Retinoic acid receptor alpha RARA Tclin Nuclear Receptor -2.97339 919.3 562
Retinoic acid receptor beta RARB Tclin Nuclear Receptor -2.51618 295.9 391
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial PDK1 Tchem Kinase -1.09156 10.3 601