Development Level

Tbio 281 | 11,651
Tchem 102 | 1,388
Tclin 42 | 612
Tdark 5 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 42 | 979
embryonic lethality prior to t... 19 | 278
preweaning lethality, incomple... 13 | 499
embryonic lethality prior to o... 11 | 239
abnormal embryo size 10 | 220
abnormal bone structure 8 | 187
enlarged heart 8 | 210
increased neutrophil cell numb... 7 | 46
abnormal behavior 6 | 298
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
short tibia 6 | 97
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
edema 5 | 59
increased circulating alkaline... 5 | 122
increased mean corpuscular hem... 5 | 96
persistence of hyaloid vascula... 5 | 33
abnormal cornea morphology 4 | 31
abnormal heart morphology 4 | 162
abnormal tail morphology 4 | 25
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased circulating creatini... 4 | 39
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 50
decreased vertical activity 4 | 208
embryonic growth retardation 4 | 106
hemorrhage 4 | 23
increased bone mineral content 4 | 108
increased circulating choleste... 4 | 66
increased startle reflex 4 | 112
prenatal lethality 4 | 28
abnormal lens morphology 3 | 81
abnormal skin morphology 3 | 50
cataract 3 | 92
decreased circulating amylase ... 3 | 28
decreased circulating bilirubi... 3 | 19
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
decreased leukocyte cell numbe... 3 | 73
decreased neutrophil cell numb... 3 | 42
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating calcium ... 3 | 34
increased circulating glucose ... 3 | 24
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased spleen weight 3 | 10
increased total body fat amoun... 3 | 134
male infertility 3 | 123
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal body wall morphology 2 | 9
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal optic disc morphology 2 | 10
abnormal retinal vasculature m... 2 | 27
abnormal tooth morphology 2 | 24
abnormal vibrissa morphology 2 | 25
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
impaired pupillary reflex 2 | 26
increased body length 2 | 32
increased circulating amylase ... 2 | 25
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased heart weight 2 | 62
increased large unstained cell... 2 | 5
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
prenatal lethality prior to he... 2 | 87
thrombocytosis 2 | 27
tremors 2 | 39

Disease

Carcinoma 319 | 11,493
ovarian cancer 259 | 8,520
osteosarcoma 230 | 7,950
glioblastoma 203 | 5,792
Cancer 194 | 2,499
psoriasis 186 | 6,694
medulloblastoma, large-cell 180 | 6,241
atypical teratoid / rhabdoid tumor 165 | 5,112
lung cancer 164 | 4,740
ependymoma 160 | 4,679
Breast cancer 149 | 3,578
invasive ductal carcinoma 124 | 2,951
malignant mesothelioma 124 | 3,232
Kidney cancer 117 | 2,613
Astrocytoma, Pilocytic 114 | 3,081
adult high grade glioma 113 | 3,801
group 3 medulloblastoma 112 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 111 | 3,291
oligodendroglioma 102 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,955
pancreatic cancer 99 | 2,398
non-small cell lung cancer 96 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 95 | 2,989
primitive neuroectodermal tumor 95 | 3,035
lung adenocarcinoma 94 | 2,716
astrocytic glioma 93 | 2,597
lung carcinoma 92 | 2,843
interstitial cystitis 91 | 2,312
subependymal giant cell astrocytoma 91 | 2,287
diabetes mellitus 83 | 1,728
pituitary cancer 79 | 1,972
cystic fibrosis 74 | 1,696
breast carcinoma 72 | 1,638
group 4 medulloblastoma 70 | 1,855
tuberculosis 70 | 2,010
ulcerative colitis 70 | 1,819
Autosomal recessive predisposition 69 | 1,442
ductal carcinoma in situ 69 | 1,745
Schizophrenia 68 | 1,160
Pick disease 67 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,962
colon cancer 56 | 1,478
juvenile dermatomyositis 52 | 1,187
astrocytoma 50 | 1,146
Alzheimer's disease 49 | 658
Breast Neoplasms 47 | 445
Multiple myeloma 47 | 1,332
adrenocortical carcinoma 46 | 1,428
Mammary Neoplasms 45 | 425
Rheumatoid arthritis 45 | 1,191
dermatomyositis 45 | 966
pediatric high grade glioma 45 | 1,064
primary pancreatic ductal adenocarcinoma 45 | 1,109
Intellectual disability 43 | 1,016
Liver Cirrhosis, Experimental 43 | 769
esophageal adenocarcinoma 42 | 737
Bipolar Disorder 41 | 666
acute quadriplegic myopathy 41 | 1,158
Seizures 40 | 596
Epilepsy 39 | 792
Obesity 38 | 678
Prostatic Neoplasms 38 | 495
Depressive disorder 37 | 409
Atopic dermatitis 36 | 952
nasopharyngeal carcinoma 36 | 1,058
spina bifida 36 | 1,074
Liver cancer 35 | 604
cutaneous lupus erythematosus 35 | 1,057
Kidney disease 34 | 430
Short stature 34 | 531
Duchenne muscular dystrophy 32 | 601
Melanoma 32 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 510
Waldenstrons macroglobulinemia 31 | 765
fibroadenoma 31 | 559
gastric carcinoma 31 | 807
Down syndrome 30 | 499
Dull intelligence 30 | 645
Heart disease 30 | 306
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Neoplasm Metastasis 30 | 168
Poor school performance 30 | 645
Stomach Neoplasms 30 | 300
medulloblastoma 30 | 720
primary Sjogren syndrome 30 | 735
Atherosclerosis 28 | 291
Carcinoma, Hepatocellular 28 | 228
Liver carcinoma 28 | 240
Mental Depression 28 | 333
Vascular disease 28 | 319
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
Orbital separation excessive 27 | 244
Osteoporosis 27 | 363
Parkinson's disease 27 | 392
Hypertension 26 | 396
progressive supranuclear palsy 26 | 676

Tissue

Endocrine System 426 | 18,159
Digestive Tract 424 | 17,369
Skin and soft tissues 423 | 17,230
Female tissues 422 | 17,400
Male tissues 422 | 17,142
Nervous System 421 | 16,725
Blood and immune system 419 | 16,909
Urinary Tract 419 | 16,678
Liver and Pancreas 415 | 16,750
Respiratory system 414 | 16,393
Cardiovascular System 406 | 15,192

Target Family

Non-IDG 214 | 12,091
Enzyme 117 | 4,145
Kinase 79 | 634
Transcription Factor 11 | 1,400
Ion Channel 5 | 344
GPCR 2 | 408
Nuclear Receptor 2 | 48

Reactome Pathway

Signaling by Receptor Tyrosine... 430 | 430
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Nucleolysin TIA-1 isoform p40 TIA1 Tbio Non-IDG -2.86461 714.2 314
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422