Development Level

Tbio 188 | 11,651
Tchem 14 | 1,388
Tdark 10 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal bone structure 3 | 187
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
prolonged QT interval 3 | 38
abnormal kidney morphology 2 | 65
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating triglyce... 2 | 42
increased neutrophil cell numb... 2 | 46
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased cardiac stroke volum... 1 | 6
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged uterus 1 | 11
fused cornea and lens 1 | 5
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged QRS complex duration 1 | 8
prolonged ST segment 1 | 36
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

ovarian cancer 123 | 8,520
Carcinoma 85 | 11,493
lung cancer 85 | 4,740
osteosarcoma 69 | 7,950
psoriasis 65 | 6,694
glioblastoma 63 | 5,792
medulloblastoma, large-cell 61 | 6,241
Multiple myeloma 58 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
atypical teratoid / rhabdoid tumor 45 | 5,112
Breast cancer 44 | 3,578
diabetes mellitus 41 | 1,728
ependymoma 37 | 4,679
malignant mesothelioma 37 | 3,232
Cancer 35 | 2,499
group 3 medulloblastoma 35 | 4,104
oligodendroglioma 34 | 2,850
Waldenstrons macroglobulinemia 33 | 765
adult high grade glioma 33 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
Astrocytoma, Pilocytic 28 | 3,081
invasive ductal carcinoma 28 | 2,951
lung carcinoma 26 | 2,843
non-small cell lung cancer 26 | 2,890
Diamond-Blackfan anemia 25 | 31
primitive neuroectodermal tumor 25 | 3,035
astrocytoma 24 | 1,146
Kidney cancer 23 | 2,613
astrocytic glioma 23 | 2,597
Pick disease 22 | 1,894
cystic fibrosis 22 | 1,696
subependymal giant cell astrocytoma 22 | 2,287
acute quadriplegic myopathy 21 | 1,158
lung adenocarcinoma 20 | 2,716
group 4 medulloblastoma 18 | 1,855
pancreatic cancer 18 | 2,398
Anemia 17 | 365
HIV Infections 17 | 102
dermatomyositis 17 | 966
Cleft Palate 16 | 271
Fatigue 16 | 182
Uranostaphyloschisis 16 | 167
Cardiac Arrhythmia 15 | 103
Cardiac conduction abnormalities 15 | 78
Conduction disorder of the heart 15 | 79
EKG abnormalities 15 | 78
Electrocardiogram abnormal 15 | 81
Electrocardiogram change 15 | 78
breast carcinoma 15 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
pituitary cancer 15 | 1,972
Delayed Puberty 14 | 97
colon cancer 14 | 1,478
interstitial cystitis 14 | 2,312
primary pancreatic ductal adenocarcinoma 14 | 1,109
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
sonic hedgehog group medulloblastoma 13 | 467
tuberculosis 13 | 2,010
ulcerative colitis 13 | 1,819
Breast Neoplasms 12 | 445
Intellectual disability 12 | 1,016
Mammary Neoplasms 12 | 425
Schizophrenia 12 | 1,160
Stomach Neoplasms 12 | 300
acute myeloid leukemia 12 | 783
cutaneous lupus erythematosus 11 | 1,057
juvenile dermatomyositis 11 | 1,187
mucosa-associated lymphoid tissue lymphoma 11 | 484
medulloblastoma 10 | 720
Autosomal recessive predisposition 9 | 1,442
Osteoporosis 9 | 363
Rheumatoid arthritis 9 | 1,191
ductal carcinoma in situ 9 | 1,745
non primary Sjogren syndrome sicca 9 | 891
primary Sjogren syndrome 9 | 735
Disease Progression 8 | 136
Duchenne muscular dystrophy 8 | 601
Liver Cirrhosis, Experimental 8 | 769
Melanoma 8 | 711
Prostatic Neoplasms 8 | 495
Short stature 8 | 531
adrenocortical carcinoma 8 | 1,428
pediatric high grade glioma 8 | 1,064
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Proteinuria 7 | 144
Skin cancer 7 | 469
active Crohn's disease 7 | 922
progressive supranuclear palsy 7 | 676
Crohn's disease 6 | 321

Tissue

Endocrine System 216 | 18,159
Digestive Tract 211 | 17,369
Male tissues 211 | 17,142
Blood and immune system 210 | 16,909
Female tissues 210 | 17,400
Nervous System 210 | 16,725
Respiratory system 210 | 16,393
Skin and soft tissues 210 | 17,230
Liver and Pancreas 208 | 16,750
Urinary Tract 208 | 16,678
Cardiovascular System 204 | 15,192

Target Family

Non-IDG 142 | 12,091
Enzyme 58 | 4,145
Kinase 12 | 634
Transcription Factor 6 | 1,400
GPCR 1 | 408

Reactome Pathway

Signaling by ROBO receptors 219 | 219
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Roundabout homolog 1 ROBO1 Tbio Non-IDG -2.15518 129.8 261
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -1.03272 8.93 160
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.58528 37.8 68
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452