Development Level

Tbio 28 | 11,445
Tchem 12 | 1,598
Tclin 8 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased total body fat amoun... 3 | 207
abnormal bone structure 2 | 187
increased circulating HDL chol... 2 | 80
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal midbrain morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating phosphat... 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hemorrhage 1 | 23
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 42 | 11,493
ovarian cancer 32 | 8,520
osteosarcoma 31 | 7,950
Cancer 28 | 2,499
glioblastoma 23 | 5,792
Kidney cancer 21 | 2,613
atypical teratoid / rhabdoid tumor 21 | 5,112
medulloblastoma, large-cell 20 | 6,241
lung cancer 19 | 4,740
Breast cancer 17 | 3,578
astrocytic glioma 17 | 2,597
ependymoma 16 | 4,679
psoriasis 16 | 6,694
lung adenocarcinoma 14 | 2,716
group 3 medulloblastoma 13 | 4,104
Noonan syndrome 12 | 34
Short stature 12 | 531
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
oligodendroglioma 12 | 2,850
pancreatic cancer 12 | 2,398
Bleeding tendency 11 | 37
Blepharoptosis 11 | 231
Intellectual disability 11 | 1,016
Muscle hypotonia 11 | 571
adult high grade glioma 11 | 3,801
malignant mesothelioma 11 | 3,232
tuberculosis 11 | 2,010
Acquired scoliosis 10 | 281
Astrocytoma, Pilocytic 10 | 3,081
Byzanthine arch palate 10 | 194
Curvature of spine 10 | 282
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Schizophrenia 10 | 1,160
Strabismus 10 | 270
Cognitive delay 9 | 608
Cryptorchidism 9 | 296
Downward slant of palpebral fissure 9 | 158
Global developmental delay 9 | 608
Melanoma 9 | 711
Mental and motor retardation 9 | 608
Neck webbing 9 | 35
Orbital separation excessive 9 | 244
Pick disease 9 | 1,894
diabetes mellitus 9 | 1,728
juvenile dermatomyositis 9 | 1,187
lung carcinoma 9 | 2,843
subependymal giant cell astrocytoma 9 | 2,287
Abnormal dermatoglyphic pattern 8 | 24
Autosomal recessive predisposition 8 | 1,442
Costello Syndrome 8 | 17
Gastrointestinal Hemorrhage 8 | 52
Joint hyperflexibility 8 | 78
LEOPARD syndrome 8 | 20
Low posterior hairline 8 | 52
Low-set, posteriorly rotated ears 8 | 110
Stomach Neoplasms 8 | 300
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
primitive neuroectodermal tumor 8 | 3,035
Aortic coarctation 7 | 30
Breast Neoplasms 7 | 445
Cardiofaciocutaneous syndrome 7 | 15
Concave bridge of nose 7 | 195
Congenital Epicanthus 7 | 177
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Electroencephalogram abnormal 7 | 101
Epistaxis 7 | 43
Feeding difficulties in infancy 7 | 175
Hepatomegaly 7 | 285
High forehead 7 | 102
Hypertrophic Cardiomyopathy 7 | 117
Hypoplastic mandible condyle 7 | 275
Lung Neoplasms 7 | 232
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Multiple myeloma 7 | 1,332
Osteoporosis 7 | 363
Pectus excavatum 7 | 100
Pulmonary Stenosis 7 | 45
Renal Cell Carcinoma 7 | 214
Short neck 7 | 140
Tall forehead 7 | 102
Thickened helices 7 | 15
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Delayed bone age 6 | 136
Epilepsy 6 | 792
Exophthalmos 6 | 112
Heart disease 6 | 306
Liver Cirrhosis, Experimental 6 | 769
Macrotia 6 | 87
Neoplasm Invasiveness 6 | 161
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Blood and immune system 50 | 16,909
Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Female tissues 50 | 17,400
Liver and Pancreas 50 | 16,750
Male tissues 50 | 17,142
Respiratory system 50 | 16,393
Skin and soft tissues 50 | 17,230
Urinary Tract 50 | 16,678
Nervous System 48 | 16,725
Cardiovascular System 47 | 15,192

Target Family

Non-IDG 22 | 12,091
Enzyme 14 | 4,145
Kinase 14 | 634

Reactome Pathway

Signaling by RAS mutants 50 | 50
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
RAS protein activator like-3 RASAL3 Tbio Non-IDG -0.25123 2.81 57