Development Level

Tbio 34 | 11,445
Tchem 14 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
hyperactivity 2 | 148
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal sleep behavior 1 | 70
abnormal urinary bladder morph... 1 | 11
cataract 1 | 92
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
edema 1 | 59
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 39 | 11,493
Cancer 32 | 2,499
ovarian cancer 32 | 8,520
osteosarcoma 31 | 7,950
lung cancer 28 | 4,740
glioblastoma 25 | 5,792
medulloblastoma, large-cell 25 | 6,241
atypical teratoid / rhabdoid tumor 22 | 5,112
psoriasis 22 | 6,694
Breast cancer 21 | 3,578
ependymoma 19 | 4,679
Kidney cancer 17 | 2,613
lung adenocarcinoma 17 | 2,716
diabetes mellitus 16 | 1,728
ulcerative colitis 16 | 1,819
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Astrocytoma, Pilocytic 14 | 3,081
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Melanoma 13 | 711
interstitial cystitis 13 | 2,312
Schizophrenia 12 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
Stomach Neoplasms 11 | 300
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung carcinoma 11 | 2,843
non-small cell lung cancer 11 | 2,890
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Multiple myeloma 10 | 1,332
Pick disease 10 | 1,894
Rheumatoid arthritis 10 | 1,191
oligodendroglioma 10 | 2,850
primitive neuroectodermal tumor 10 | 3,035
Cell Transformation, Neoplastic 9 | 97
Lung Neoplasms 9 | 232
Prostatic Neoplasms 9 | 495
acute quadriplegic myopathy 9 | 1,158
ductal carcinoma in situ 9 | 1,745
pituitary cancer 9 | 1,972
subependymal giant cell astrocytoma 9 | 2,287
Endometriosis 8 | 540
Neoplasm Metastasis 8 | 168
Neoplastic Cell Transformation 8 | 89
Ovarian Neoplasms 8 | 102
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
group 4 medulloblastoma 8 | 1,855
invasive ductal carcinoma 8 | 2,951
nasopharyngeal carcinoma 8 | 1,058
ovarian neoplasm 8 | 99
primary pancreatic ductal adenocarcinoma 8 | 1,109
tuberculosis 8 | 2,010
Animal Mammary Neoplasms 7 | 136
Bipolar Disorder 7 | 666
Mammary Neoplasms, Animal 7 | 136
Mammary Neoplasms, Experimental 7 | 154
Neoplasm Invasiveness 7 | 161
Skin cancer 7 | 469
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Adenocarcinoma 6 | 122
Adenoma 6 | 167
Asthma 6 | 385
Carcinoma, Squamous Cell 6 | 110
Depressive disorder 6 | 409
Disease Progression 6 | 136
Endometrial cancer 6 | 311
Immune system cancer 6 | 140
Kidney disease 6 | 430
Liver neoplasms 6 | 130
Major Depressive Disorder 6 | 301
Neoplasms, Experimental 6 | 40
Squamous cell carcinoma 6 | 129
Unipolar Depression 6 | 250
Vascular disease 6 | 319
colon cancer 6 | 1,478
fibroadenoma 6 | 559
mucosa-associated lymphoid tissue lymphoma 6 | 484
Anemia 5 | 365
Arthritis, Juvenile 5 | 126
Atopic dermatitis 5 | 952
Colonic Neoplasms 5 | 142
Epilepsy 5 | 792
Heart disease 5 | 306
Juvenile arthritis 5 | 126
Mental Depression 5 | 333
Pancreatic Neoplasms 5 | 85
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
gastric carcinoma 5 | 807
juvenile dermatomyositis 5 | 1,187
pancreatic carcinoma 5 | 562

Tissue

Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 10 | 4,145
Kinase 9 | 634
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

Signaling by PTK6 53 | 53
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.99923 14.5 99
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139