Development Level

Tbio 29 | 11,651
Tchem 16 | 1,388
Tclin 6 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 7 | 979
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
preweaning lethality, incomple... 3 | 499
abnormal femur morphology 2 | 14
decreased circulating creatini... 2 | 39
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small testis 1 | 58

Disease

Carcinoma 47 | 11,493
ovarian cancer 38 | 8,520
Cancer 32 | 2,499
psoriasis 31 | 6,694
osteosarcoma 30 | 7,950
lung cancer 29 | 4,740
Breast cancer 28 | 3,578
glioblastoma 24 | 5,792
medulloblastoma, large-cell 24 | 6,241
atypical teratoid / rhabdoid tumor 23 | 5,112
Kidney cancer 22 | 2,613
pancreatic cancer 21 | 2,398
Astrocytoma, Pilocytic 19 | 3,081
lung adenocarcinoma 19 | 2,716
ependymoma 18 | 4,679
invasive ductal carcinoma 18 | 2,951
malignant mesothelioma 18 | 3,232
group 4 medulloblastoma 16 | 1,855
interstitial cystitis 16 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
ductal carcinoma in situ 14 | 1,745
juvenile dermatomyositis 14 | 1,187
oligodendroglioma 14 | 2,850
pituitary cancer 14 | 1,972
breast carcinoma 13 | 1,638
lung carcinoma 13 | 2,843
Autosomal recessive predisposition 12 | 1,442
Kidney disease 12 | 430
Short stature 12 | 531
adult high grade glioma 12 | 3,801
cystic fibrosis 12 | 1,696
group 3 medulloblastoma 12 | 4,104
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
adrenocortical carcinoma 11 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
gastric carcinoma 11 | 807
ulcerative colitis 11 | 1,819
Breast Neoplasms 10 | 445
Byzanthine arch palate 10 | 194
Joint hyperflexibility 10 | 78
Mammary Neoplasms 10 | 425
Myopia 10 | 176
dermatomyositis 10 | 966
nasopharyngeal carcinoma 10 | 1,058
primary pancreatic ductal adenocarcinoma 10 | 1,109
Acquired scoliosis 9 | 281
Atopic dermatitis 9 | 952
Curvature of spine 9 | 282
Duchenne muscular dystrophy 9 | 601
Epilepsy 9 | 792
Liver Cirrhosis, Experimental 9 | 769
Pick disease 9 | 1,894
Seizures 9 | 596
astrocytic glioma 9 | 2,597
diabetes mellitus 9 | 1,728
non-small cell lung cancer 9 | 2,890
primitive neuroectodermal tumor 9 | 3,035
tuberculosis 9 | 2,010
Atherosclerosis 8 | 291
Cognitive delay 8 | 608
Delayed bone age 8 | 136
Global developmental delay 8 | 608
Liver cancer 8 | 604
Lung Neoplasms 8 | 232
Mammary Neoplasms, Experimental 8 | 154
Mental and motor retardation 8 | 608
Orbital separation excessive 8 | 244
Progressive disorder 8 | 142
Schizophrenia 8 | 1,160
Sensorineural Hearing Loss (disorder) 8 | 284
Adenocarcinoma 7 | 122
Animal Mammary Neoplasms 7 | 136
Becker muscular dystrophy 7 | 191
Blepharoptosis 7 | 231
Cataract 7 | 297
Cleft Palate 7 | 271
Downward slant of palpebral fissure 7 | 158
Feeding difficulties in infancy 7 | 175
Frontal bossing 7 | 157
Hepatomegaly 7 | 285
Lens Opacities 7 | 231
Mammary Neoplasms, Animal 7 | 136
Nephrotic Syndrome 7 | 78
Noonan syndrome 7 | 34
Stomach Neoplasms 7 | 300
esophageal adenocarcinoma 7 | 737
Arthritis 6 | 290
Chronic Lymphocytic Leukemia 6 | 262
Ventricular Septal Defects 6 | 119
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
fibroadenoma 6 | 559
limb girdle muscular dystrophy 2A 6 | 213
primary Sjogren syndrome 6 | 735

Tissue

Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Male tissues 52 | 17,142
Skin and soft tissues 52 | 17,230
Blood and immune system 51 | 16,909
Liver and Pancreas 51 | 16,750
Respiratory system 51 | 16,393
Urinary Tract 51 | 16,678
Cardiovascular System 50 | 15,192
Nervous System 50 | 16,725

Target Family

Non-IDG 30 | 12,091
Enzyme 11 | 4,145
Kinase 6 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

Signaling by PDGF 52 | 52
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749