Development Level

Tbio 196 | 10,625
Tchem 110 | 1,890
Tclin 55 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 17 | 633
decreased body weight 11 | 174
decreased total body fat amoun... 10 | 186
embryonic lethality prior to t... 8 | 187
decreased lean body mass 7 | 195
enlarged heart 7 | 111
abnormal embryo size 6 | 112
decreased circulating choleste... 6 | 85
abnormal behavior 5 | 226
decreased body length 5 | 108
decreased bone mineral content 5 | 157
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
abnormal bone structure 4 | 131
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating glucose ... 4 | 121
decreased circulating total pr... 4 | 41
decreased grip strength 4 | 123
increased circulating alkaline... 4 | 119
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal cornea morphology 3 | 24
abnormal forebrain development 3 | 18
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
decreased circulating serum al... 3 | 79
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
decreased rib number 3 | 59
increased bone mineral content 3 | 92
increased circulating phosphat... 3 | 24
increased lean body mass 3 | 107
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal femur morphology 2 | 14
abnormal seminal vesicle morph... 2 | 47
abnormal testis morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating sodium l... 2 | 18
decreased erythrocyte cell num... 2 | 43
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
irregularly shaped pupil 2 | 7
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal ear morphology 1 | 5
abnormal kidney morphology 1 | 30
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased total retina thickne... 1 | 20
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased body length 1 | 20
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 211 | 8,484
osteosarcoma 209 | 7,933
psoriasis 165 | 6,685
glioblastoma 156 | 5,572
medulloblastoma, large-cell 156 | 6,234
Cancer 152 | 2,346
lung cancer 142 | 4,466
atypical teratoid / rhabdoid tumor 118 | 4,369
Breast cancer 100 | 3,094
pilocytic astrocytoma 97 | 3,086
malignant mesothelioma 94 | 3,162
Carcinoma 91 | 2,147
oligodendroglioma 90 | 2,849
invasive ductal carcinoma 87 | 2,950
pediatric high grade glioma 82 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 81 | 3,289
ependymoma 80 | 2,514
lung adenocarcinoma 80 | 2,713
interstitial cystitis 79 | 2,299
subependymal giant cell astrocytoma 76 | 2,287
lung carcinoma 74 | 2,844
primitive neuroectodermal tumor 70 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 69 | 2,956
astrocytic glioma 68 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,988
ulcerative colitis 68 | 2,087
pancreatic cancer 67 | 2,300
non-small cell lung cancer 63 | 2,798
pituitary cancer 59 | 1,972
diabetes mellitus 58 | 1,663
group 4 medulloblastoma 58 | 1,875
tuberculosis 53 | 1,557
Multiple myeloma 52 | 1,327
Pick disease 52 | 1,893
cystic fibrosis 52 | 1,665
ductal carcinoma in situ 49 | 1,745
group 3 medulloblastoma 49 | 2,254
astrocytoma 48 | 1,493
medulloblastoma 45 | 1,524
Rheumatoid Arthritis 44 | 1,160
breast carcinoma 43 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,795
juvenile dermatomyositis 42 | 1,189
primary pancreatic ductal adenocarcinoma 42 | 1,271
adult high grade glioma 41 | 2,148
colon cancer 38 | 1,475
Mammary Neoplasms 34 | 410
adrenocortical carcinoma 34 | 1,427
cutaneous lupus erythematosus 34 | 1,056
gastric carcinoma 34 | 832
Schizophrenia 33 | 501
dermatomyositis 31 | 933
posterior fossa group A ependymoma 31 | 1,511
Prostatic Neoplasms 30 | 471
atypical teratoid/rhabdoid tumor 29 | 1,095
primary Sjogren syndrome 29 | 789
Alzheimer's disease 27 | 644
Parkinson's disease 27 | 364
Kidney disease 26 | 396
Lung Neoplasms 26 | 171
Obesity 26 | 616
posterior fossa group B ependymoma 26 | 1,530
spina bifida 26 | 1,064
Vascular disease 25 | 281
acute quadriplegic myopathy 25 | 1,157
esophageal adenocarcinoma 25 | 737
non-small cell lung carcinoma 25 | 413
Waldenstrons macroglobulinemia 24 | 765
nasopharyngeal carcinoma 24 | 1,056
Intellectual disability 23 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
pancreatic carcinoma 22 | 567
sonic hedgehog group medulloblastoma 22 | 1,482
Asthma 21 | 349
Duchenne muscular dystrophy 21 | 602
Liver carcinoma 21 | 217
Polycystic Ovary Syndrome 21 | 332
Atopic dermatitis 20 | 944
Down syndrome 20 | 548
HIV Infections 20 | 100
Renal Cell Carcinoma 20 | 199
tuberculosis and treatment for 6 months 20 | 686
Anemia 19 | 252
Mammary Neoplasms, Experimental 19 | 150
Stomach Neoplasms 19 | 282
fibroadenoma 19 | 557
non primary Sjogren syndrome sicca 19 | 840
progressive supranuclear palsy 19 | 674
Animal Mammary Neoplasms 18 | 136
Autistic Disorder 18 | 320
Heart disease 18 | 279
Hypersensitivity reaction type II disease 18 | 235
sarcoidosis 18 | 358
Atherosclerosis 17 | 275
Multiple Sclerosis 17 | 498
Osteoporosis 17 | 257
Peripheral Neuropathy 17 | 303
active Crohn's disease 17 | 918
Myocardial Ischemia 16 | 169
hepatocellular carcinoma 16 | 532

Tissue

Endocrine System 368 | 18,512
Female tissues 368 | 18,647
Nervous System 368 | 18,561
Digestive Tract 367 | 18,473
Urinary Tract 367 | 18,444
Liver and Pancreas 366 | 18,136
Blood and immune system 365 | 17,995
Cardiovascular System 364 | 17,958
Skin and soft tissues 364 | 18,115
Male tissues 363 | 17,969
Respiratory system 358 | 17,484

Target Family

Non-IDG 168 | 11,971
Enzyme 114 | 4,146
Kinase 67 | 634
Transcription Factor 10 | 1,400
Ion Channel 8 | 341
Nuclear Receptor 1 | 48

Reactome Pathway

Signaling by PDGF 368 | 368
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416