Development Level

Tbio 104 | 11,445
Tchem 36 | 1,598
Tclin 13 | 613
Tdark 10 | 6,588

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to t... 7 | 278
abnormal behavior 6 | 298
embryonic lethality prior to o... 6 | 239
preweaning lethality, incomple... 6 | 499
decreased vertical activity 4 | 208
enlarged heart 4 | 210
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal coat-hair pigmentatio... 2 | 64
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
cataract 2 | 92
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
enlarged uterus 2 | 11
hydrometra 2 | 53
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased grip strength 2 | 41
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal ovary morphology 1 | 7
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
enlarged epididymis 1 | 31
enlarged kidney 1 | 14
enlarged ovary 1 | 2
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart rate 1 | 23
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
premature death 1 | 5
shortened RR interval 1 | 17
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 101 | 11,493
ovarian cancer 95 | 8,520
osteosarcoma 77 | 7,950
psoriasis 75 | 6,694
Cancer 70 | 2,499
lung cancer 69 | 4,740
glioblastoma 57 | 5,792
medulloblastoma, large-cell 56 | 6,241
Breast cancer 52 | 3,578
atypical teratoid / rhabdoid tumor 45 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
invasive ductal carcinoma 39 | 2,951
malignant mesothelioma 39 | 3,232
group 3 medulloblastoma 35 | 4,104
lung adenocarcinoma 35 | 2,716
ductal carcinoma in situ 33 | 1,745
ependymoma 33 | 4,679
breast carcinoma 32 | 1,638
non-small cell lung cancer 32 | 2,890
lung carcinoma 30 | 2,843
Kidney cancer 29 | 2,613
Astrocytoma, Pilocytic 28 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
pituitary cancer 28 | 1,972
Multiple myeloma 27 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
group 4 medulloblastoma 26 | 1,855
oligodendroglioma 26 | 2,850
primitive neuroectodermal tumor 26 | 3,035
Pick disease 25 | 1,894
adult high grade glioma 25 | 3,801
astrocytoma 25 | 1,146
subependymal giant cell astrocytoma 25 | 2,287
Schizophrenia 24 | 1,160
interstitial cystitis 24 | 2,312
pancreatic cancer 24 | 2,398
Breast Neoplasms 23 | 445
Mammary Neoplasms 23 | 425
Rheumatoid arthritis 23 | 1,191
acute quadriplegic myopathy 23 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Prostatic Neoplasms 21 | 495
colon cancer 21 | 1,478
astrocytic glioma 20 | 2,597
acute myeloid leukemia 19 | 783
cystic fibrosis 19 | 1,696
diabetes mellitus 19 | 1,728
Endometriosis 18 | 540
fibroadenoma 17 | 559
Waldenstrons macroglobulinemia 16 | 765
Alzheimer's disease 15 | 658
Obesity 15 | 678
aldosterone-producing adenoma 15 | 665
gastric cancer 14 | 459
juvenile dermatomyositis 14 | 1,187
Bipolar Disorder 13 | 666
Carcinoma, Hepatocellular 13 | 228
adrenocortical carcinoma 13 | 1,428
nasopharyngeal carcinoma 13 | 1,058
ulcerative colitis 13 | 1,819
Down syndrome 12 | 499
Intellectual disability 12 | 1,016
Liver Cirrhosis, Experimental 12 | 769
Liver carcinoma 12 | 240
Stomach Neoplasms 12 | 300
pancreatic carcinoma 12 | 562
pediatric high grade glioma 12 | 1,064
spina bifida 12 | 1,074
Small head 11 | 374
non primary Sjogren syndrome sicca 11 | 891
tuberculosis 11 | 2,010
Autosomal recessive predisposition 10 | 1,442
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Lung Neoplasms 10 | 232
Mental and motor retardation 10 | 608
Vascular disease 10 | 319
hepatocellular carcinoma 10 | 547
non-small cell lung carcinoma 10 | 317
Adenocarcinoma 9 | 122
Alcoholic Intoxication, Chronic 9 | 289
Amyotrophic lateral sclerosis 9 | 451
Atopic dermatitis 9 | 952
Carcinoma, Squamous Cell 9 | 110
Crohn's disease 9 | 321
Dull intelligence 9 | 645
Epilepsy 9 | 792
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Squamous cell carcinoma 9 | 129
cutaneous lupus erythematosus 9 | 1,057
dermatomyositis 9 | 966
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cleft Palate 8 | 271
Depressive disorder 8 | 409
Seizures 8 | 596
active Crohn's disease 8 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510

Tissue

Endocrine System 162 | 18,159
Blood and immune system 160 | 16,909
Digestive Tract 159 | 17,369
Female tissues 159 | 17,400
Liver and Pancreas 158 | 16,750
Male tissues 158 | 17,142
Skin and soft tissues 158 | 17,230
Nervous System 157 | 16,725
Respiratory system 157 | 16,393
Urinary Tract 157 | 16,678
Cardiovascular System 153 | 15,192

Target Family

Non-IDG 67 | 12,091
Enzyme 48 | 4,145
Transcription Factor 17 | 1,400
Epigenetic 12 | 242
Nuclear Receptor 11 | 48
Kinase 8 | 634

Reactome Pathway

Signaling by Nuclear Receptors 163 | 163
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Dehydrogenase/reductase SDR family member 4 DHRS4 Tbio Enzyme -1.65486 46.6 122
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Protein argonaute-4 AGO4 Tbio Non-IDG -1.42077 23.0 121
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200