Development Level

Tchem 7 | 1,890
Tbio 4 | 10,625

IMPC Phenotype

abnormal QRS complex 1 | 25
abnormal forced expiratory flo... 1 | 1
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased body temperature 1 | 2
decreased body weight 1 | 174
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
preweaning lethality, complete... 1 | 633

Disease

osteosarcoma 7 | 7,933
Alzheimer's disease 6 | 644
Cancer 6 | 2,346
Mammary Neoplasms 6 | 410
glioblastoma 6 | 5,572
medulloblastoma, large-cell 6 | 6,234
pilocytic astrocytoma 5 | 3,086
ependymoma 4 | 2,514
ovarian cancer 4 | 8,491
pediatric high grade glioma 4 | 2,712
primitive neuroectodermal tumor 4 | 3,031
Carcinoma, Pancreatic Ductal 3 | 19
Hidradenitis suppurativa 3 | 12
adrenocortical carcinoma 3 | 1,427
atypical teratoid / rhabdoid tumor 3 | 4,369
diabetes mellitus 3 | 1,663
invasive ductal carcinoma 3 | 2,950
juvenile dermatomyositis 3 | 1,189
lung cancer 3 | 4,473
malignant mesothelioma 3 | 3,163
non-small cell lung cancer 3 | 2,798
oligodendroglioma 3 | 2,849
psoriasis 3 | 6,685
Acne 2 | 20
Amyloidosis 2 | 68
Breast cancer 2 | 3,098
Cadasil 2 | 10
Carcinoma 2 | 2,147
Dementia 2 | 129
Duchenne muscular dystrophy 2 | 602
Hajdu-Cheney syndrome 2 | 8
Hidradenitis suppurativa, familial 2 | 3
Kidney disease 2 | 397
Neurodegenerative disease 2 | 383
Pain agnosia 2 | 99
Shipyard eye 2 | 14
Type 1 diabetes mellitus 2 | 104
astrocytoma 2 | 1,493
atypical teratoid/rhabdoid tumor 2 | 1,095
dermatomyositis 2 | 966
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
pancreatic cancer 2 | 2,300
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
Adenoid Cystic Carcinoma 1 | 99
Age related macular degeneration 1 | 84
Alagille syndrome 1 | 15
Alobar Holoprosencephaly 1 | 14
Anemia 1 | 252
COPD 1 | 116
Cardiomyopathy 1 | 110
Cardiomyopathy, Dilated 1 | 47
Cerebrovascular disease 1 | 231
Cholestasis 1 | 93
Choreatic disease 1 | 27
Chronic obstructive pulmonary disease 1 | 147
Cleft Lip 1 | 91
Cleft palate 1 | 125
Congenital Heart Defects 1 | 37
Congenital heart disease 1 | 63
Conjunctivitis 1 | 18
Corneal Opacity 1 | 3
Coronary artery disease 1 | 240
Craniofacial Abnormalities 1 | 147
Deafness 1 | 18
Diarrhea 1 | 155
Dilated cardiomyopathy 1 | 51
Endocarditis 1 | 18
Facies 1 | 8
Frontotemporal dementia 1 | 47
IGA Glomerulonephritis 1 | 454
Liver disease 1 | 219
Lobar Holoprosencephaly 1 | 14
Lung Neoplasms 1 | 171
Macular degeneration 1 | 44
Malignant neoplasm of prostate 1 | 67
Multiple Sclerosis 1 | 498
Neuroblastoma 1 | 78
Neutropenia 1 | 78
Osteoporosis 1 | 259
Prostate cancer 1 | 172
Pseudobulbar palsy 1 | 7
SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR 1 | 14
Salivary Gland Neoplasms 1 | 45
Semilobar Holoprosencephaly 1 | 14
Spinocerebellar ataxia type 17 1 | 7
Syndactyly 1 | 56
Systemic scleroderma 1 | 66
Tetralogy of Fallot 1 | 38
Vitiligo 1 | 71
breast carcinoma 1 | 1,614
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,670
dentatorubral-pallidoluysian atrophy 1 | 21
progressive supranuclear palsy 1 | 674
systemic lupus erythematosus 1 | 172
tuberculosis 1 | 1,563

Tissue

Blood and immune system 11 | 17,994
Cardiovascular System 11 | 17,957
Digestive Tract 11 | 18,472
Endocrine System 11 | 18,511
Female tissues 11 | 18,646
Liver and Pancreas 11 | 18,135
Male tissues 11 | 17,968
Nervous System 11 | 18,560
Respiratory system 11 | 17,483
Skin and soft tissues 11 | 18,114
Urinary Tract 11 | 18,443

Target Family

Non-IDG 6 | 11,969
Enzyme 5 | 4,146

Reactome Pathway

Signaling by NOTCH4 11 | 11
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Delta-like protein 4 DLL4 Tbio Non-IDG -2.35311 240.0 323
Nicastrin NCSTN Tbio Non-IDG -2.13111 143.4 321
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.55352 421.8 301
Presenilin-2 PSEN2 Tchem Enzyme -2.55846 585.2 282
Gamma-secretase subunit APH-1A APH1A Tchem Enzyme -1.85660 74.0 250
Protein jagged-1 JAG1 Tchem Non-IDG -3.05420 1096.8 376
Gamma-secretase subunit APH-1B APH1B Tchem Enzyme -1.15543 13.7 52
Delta-like protein 1 DLL1 Tbio Non-IDG -3.08442 1168.8 297
Neurogenic locus notch homolog protein 4 NOTCH4 Tchem Non-IDG -2.71635 520.2 174