Development Level

Tbio 7 | 11,651
Tchem 4 | 1,388

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal forced expiratory flo... 1 | 1
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 7 | 11,493
osteosarcoma 7 | 7,950
Alzheimer's disease 6 | 658
Cancer 6 | 2,499
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
Schizophrenia 5 | 1,160
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
Astrocytoma, Pilocytic 4 | 3,081
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
ovarian cancer 4 | 8,520
Alzheimer Disease 3 | 83
Breast cancer 3 | 3,578
Carcinoma, Pancreatic Ductal 3 | 20
Dementia 3 | 175
Hidradenitis suppurativa 3 | 13
Hidradenitis suppurativa, familial 3 | 3
diabetes mellitus 3 | 1,728
group 3 medulloblastoma 3 | 4,104
juvenile dermatomyositis 3 | 1,187
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
ALZHEIMER DISEASE 2 2 | 5
Acne 2 | 52
Alzheimer Disease 4 2 | 3
Amyloidosis 2 | 67
Asphyxia neonatorum 2 | 11
Bipolar Disorder 2 | 666
Brachydactyly 2 | 156
Cadasil 2 | 10
Cardiomyopathy 2 | 116
Cardiomyopathy, Dilated 2 | 83
Cataract 2 | 297
Cerebrovascular disease 2 | 238
Congestive heart failure 2 | 113
Dilated cardiomyopathy 2 | 56
Failure to gain weight 2 | 365
Familial isolated dilated cardiomyopathy 2 | 41
Frontotemporal dementia 2 | 51
Heart failure 2 | 162
Kidney disease 2 | 430
LEFT VENTRICULAR NONCOMPACTION 10 2 | 40
LEFT VENTRICULAR NONCOMPACTION 8 2 | 40
Lens Opacities 2 | 231
Neurodegenerative disease 2 | 414
Pain agnosia 2 | 104
Pediatric failure to thrive 2 | 365
Shipyard eye 2 | 15
Short distal phalanges 2 | 50
Strabismus 2 | 270
Syncope 2 | 22
Syndactyly 2 | 88
Tetralogy of Fallot 2 | 67
Type 1 diabetes mellitus 2 | 109
Ventricular Septal Defects 2 | 119
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
pediatric high grade glioma 2 | 1,064
posterior fossa group B ependymoma 2 | 416
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Abnormal brain FDG positron emission tomography 1 | 9
Abnormal nasal morphology 1 | 16
Abnormality of the metacarpal bones 1 | 17
Behavioral variant of frontotemporal dementia 1 | 8
Brain Neoplasms 1 | 33
Claw hand 1 | 26
Compulsive hoarding 1 | 7
Cutis marmorata 1 | 32
Developmental arithmetic disorder 1 | 8
Difficulty making arithmetical calculations 1 | 8
Dysphasia 1 | 23
EEG with continuous slow activity 1 | 7
Echolalia 1 | 12
Excess nuchal skin 1 | 30
Frontotemporal cerebral atrophy 1 | 8
Hyperorality 1 | 7
Hyperphagia 1 | 23
Increased appetite (finding) 1 | 23
Neurodegenerative Diseases 1 | 38
Pancreatic Insufficiency 1 | 13
Primitive reflexes (palmomental, snout, glabellar) 1 | 7
Repeated speech 1 | 9
Restrictive behavior 1 | 7
Restrictive behavior, interests, and activities 1 | 7
Short ulnae 1 | 24
Skull defect 1 | 10
Treatment-resistant schizophrenia 1 | 6
ULNAR HYPOPLASIA 1 | 24

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Nervous System 10 | 16,725

Target Family

Non-IDG 6 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

Signaling by NOTCH4 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Nicastrin NCSTN Tbio Non-IDG -2.15220 133.2 357
Gamma-secretase subunit APH-1A APH1A Tbio Enzyme -1.87175 70.7 290
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Neurogenic locus notch homolog protein 4 NOTCH4 Tchem Non-IDG -2.75010 557.0 225
Presenilin-2 PSEN2 Tchem Enzyme -2.78856 585.9 310
Delta-like protein 1 DLL1 Tbio Non-IDG -3.09375 1190.2 344
Protein jagged-2 JAG2 Tbio Non-IDG -2.56606 327.5 353