Development Level

Tbio 37 | 11,651
Tchem 9 | 1,388
Tclin 1 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased body weight 2 | 161
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
increased lymphocyte cell numb... 2 | 32
abnormal behavior 1 | 298
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal forced expiratory flo... 1 | 1
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased respiratory quotient 1 | 16
decreased tidal volume 1 | 1
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 34 | 11,493
ovarian cancer 29 | 8,520
Cancer 26 | 2,499
glioblastoma 26 | 5,792
medulloblastoma, large-cell 24 | 6,241
Breast cancer 23 | 3,578
osteosarcoma 21 | 7,950
atypical teratoid / rhabdoid tumor 20 | 5,112
psoriasis 20 | 6,694
lung cancer 19 | 4,740
adult high grade glioma 18 | 3,801
Astrocytoma, Pilocytic 17 | 3,081
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
group 3 medulloblastoma 15 | 4,104
interstitial cystitis 15 | 2,312
Alzheimer's disease 13 | 658
ependymoma 13 | 4,679
malignant mesothelioma 13 | 3,232
non-small cell lung cancer 12 | 2,890
oligodendroglioma 12 | 2,850
invasive ductal carcinoma 11 | 2,951
pancreatic cancer 11 | 2,398
primitive neuroectodermal tumor 11 | 3,035
lung adenocarcinoma 10 | 2,716
Kidney cancer 9 | 2,613
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
lung carcinoma 9 | 2,843
primary pancreatic ductal adenocarcinoma 9 | 1,109
Schizophrenia 8 | 1,160
astrocytoma 8 | 1,146
tuberculosis 8 | 2,010
Carcinoma, Pancreatic Ductal 7 | 20
Failure to gain weight 7 | 365
Pediatric failure to thrive 7 | 365
Rheumatoid arthritis 7 | 1,191
Strabismus 7 | 270
adrenocortical carcinoma 7 | 1,428
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
gastric carcinoma 7 | 807
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
juvenile dermatomyositis 7 | 1,187
Cataract 6 | 297
Lens Opacities 6 | 231
Seizures 6 | 596
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Adenoid Cystic Carcinoma 5 | 99
Atopic dermatitis 5 | 952
Brachydactyly 5 | 156
Carcinoma, Adenoid Cystic 5 | 99
Carcinoma, Squamous Cell 5 | 110
Epilepsy 5 | 792
Esophageal Squamous Cell Carcinoma 5 | 77
Lung Neoplasms 5 | 232
Lymphoid leukemia 5 | 160
Squamous cell carcinoma of esophagus 5 | 77
Syndactyly 5 | 88
acute myeloid leukemia 5 | 783
cutaneous lupus erythematosus 5 | 1,057
diabetes mellitus 5 | 1,728
pediatric high grade glioma 5 | 1,064
progressive supranuclear palsy 5 | 676
Bipolar Disorder 4 | 666
Bladder Neoplasm 4 | 112
Blepharoptosis 4 | 231
Cerebrovascular disease 4 | 238
Colonic Neoplasms 4 | 142
Craniofacial Abnormalities 4 | 151
Dementia 4 | 175
Diarrhea 4 | 253
Endometriosis 4 | 540
Glaucoma 4 | 239
Hypoplastic mandible condyle 4 | 275
Immune system cancer 4 | 140
Liver carcinoma 4 | 240
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
Pick's disease 4 | 15
Short stature 4 | 531
Tetralogy of Fallot 4 | 67
Urinary Bladder Neoplasms 4 | 114
Ventricular Septal Defects 4 | 119
active Crohn's disease 4 | 922
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
spina bifida 4 | 1,074

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 47 | 15,192

Target Family

Non-IDG 23 | 12,091
Enzyme 10 | 4,145
Transcription Factor 10 | 1,400
Epigenetic 4 | 242
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH3 48 | 48
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
Pre-B-cell leukemia transcription factor 1 PBX1 Tbio Transcription Factor -2.30640 200.0 232
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
SNW domain-containing protein 1 SNW1 Tbio Non-IDG -1.59688 46.1 88
DNA-binding protein Ikaros IKZF1 Tbio Transcription Factor -2.66732 483.6 400
Transforming acidic coiled-coil-containing protein 3 TACC3 Tbio Non-IDG -1.99617 101.2 222
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775