Development Level

Tbio 23 | 11,651
Tchem 8 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal forced expiratory flo... 1 | 1
abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 19 | 11,493
medulloblastoma, large-cell 19 | 6,241
ovarian cancer 17 | 8,520
osteosarcoma 16 | 7,950
glioblastoma 15 | 5,792
Cancer 14 | 2,499
atypical teratoid / rhabdoid tumor 14 | 5,112
psoriasis 12 | 6,694
group 3 medulloblastoma 11 | 4,104
lung cancer 11 | 4,740
Alzheimer's disease 10 | 658
ependymoma 10 | 4,679
Breast cancer 9 | 3,578
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
adult high grade glioma 8 | 3,801
juvenile dermatomyositis 8 | 1,187
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
Schizophrenia 7 | 1,160
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
oligodendroglioma 7 | 2,850
tuberculosis 7 | 2,010
interstitial cystitis 6 | 2,312
invasive ductal carcinoma 6 | 2,951
Failure to gain weight 5 | 365
Kidney cancer 5 | 2,613
Pediatric failure to thrive 5 | 365
Pick disease 5 | 1,894
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
diabetes mellitus 5 | 1,728
pancreatic cancer 5 | 2,398
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
ulcerative colitis 5 | 1,819
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Brachydactyly 4 | 156
Cataract 4 | 297
Dementia 4 | 175
Epilepsy 4 | 792
Lens Opacities 4 | 231
Seizures 4 | 596
Short distal phalanges 4 | 50
Strabismus 4 | 270
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
Adenoid Cystic Carcinoma 3 | 99
Alagille syndrome 3 | 15
Alzheimer Disease 3 | 83
Amnestic disorder 3 | 35
Amyotrophic lateral sclerosis 3 | 451
Anemia 3 | 365
Atrial Septal Defects 3 | 85
Carcinoma, Adenoid Cystic 3 | 99
Carcinoma, Pancreatic Ductal 3 | 20
Cerebrovascular disease 3 | 238
Cryptorchidism 3 | 296
Deafness 3 | 198
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Encephalitis 3 | 64
Hidradenitis suppurativa 3 | 13
Hidradenitis suppurativa, familial 3 | 3
Hydrocephalus 3 | 152
Hypoplastic mandible condyle 3 | 275
Liver cancer 3 | 604
Long narrow head 3 | 75
Lung Neoplasms 3 | 232
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Narrow cranium shape 3 | 75
Narrow head shape 3 | 75
Narrow skull shape 3 | 75
Neurodegenerative disease 3 | 414
Orbital separation excessive 3 | 244
Penile hypospadias 3 | 106
Pick's disease 3 | 15
Rheumatoid arthritis 3 | 1,191
Syndactyly 3 | 88
Tetralogy of Fallot 3 | 67
Turridolichocephaly 3 | 75
Ventricular Septal Defects 3 | 119
adrenocortical carcinoma 3 | 1,428
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
non-small cell lung cancer 3 | 2,890
sonic hedgehog group medulloblastoma 3 | 467
subependymal giant cell astrocytoma 3 | 2,287
Polyhydramnios 2 | 108
Prominent eyes 2 | 96
Thin, sparse hair 2 | 59

Tissue

Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678

Target Family

Non-IDG 17 | 12,091
Enzyme 10 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Signaling by NOTCH2 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Nicastrin NCSTN Tbio Non-IDG -2.15220 133.2 357
Mastermind-like protein 1 MAML1 Tbio Non-IDG -1.65962 41.3 189
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.82854 72.4 136
Recombining binding protein suppressor of hairless RBPJ Tbio Transcription Factor -2.67790 444.5 266
Gamma-secretase subunit APH-1A APH1A Tbio Enzyme -1.87175 70.7 290
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139