Development Level

Tbio 20 | 10,625
Tchem 11 | 1,890
Tdark 1 | 7,003

IMPC Phenotype

decreased lean body mass 3 | 195
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal retina morphology 1 | 100
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased body temperature 1 | 2
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating serum al... 1 | 25
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
preweaning lethality, incomple... 1 | 260

Disease

medulloblastoma, large-cell 20 | 6,234
ovarian cancer 17 | 8,491
osteosarcoma 16 | 7,933
glioblastoma 15 | 5,572
Cancer 13 | 2,346
atypical teratoid / rhabdoid tumor 12 | 4,369
psoriasis 12 | 6,685
lung cancer 11 | 4,473
Alzheimer's disease 10 | 644
Mammary Neoplasms 9 | 410
pediatric high grade glioma 9 | 2,712
primitive neuroectodermal tumor 9 | 3,031
Breast cancer 8 | 3,098
ependymoma 8 | 2,514
juvenile dermatomyositis 8 | 1,189
pilocytic astrocytoma 8 | 3,086
invasive ductal carcinoma 7 | 2,950
lung carcinoma 7 | 2,844
oligodendroglioma 7 | 2,849
Pick disease 6 | 1,893
astrocytoma 6 | 1,493
group 4 medulloblastoma 6 | 1,875
interstitial cystitis 6 | 2,299
malignant mesothelioma 6 | 3,163
pancreatic cancer 6 | 2,300
sonic hedgehog group medulloblastoma 6 | 1,482
ulcerative colitis 6 | 2,087
Carcinoma 5 | 2,147
acute quadriplegic myopathy 5 | 1,157
adult high grade glioma 5 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,271
progressive supranuclear palsy 5 | 674
tuberculosis 5 | 1,563
Atopic dermatitis 4 | 944
Duchenne muscular dystrophy 4 | 602
acute myeloid leukemia 4 | 785
adrenocortical carcinoma 4 | 1,427
group 3 medulloblastoma 4 | 2,254
lung adenocarcinoma 4 | 2,714
Adenoid Cystic Carcinoma 3 | 99
Alagille syndrome 3 | 15
Carcinoma, Pancreatic Ductal 3 | 19
Dementia 3 | 129
Hidradenitis suppurativa 3 | 12
Lung Neoplasms 3 | 171
Neurodegenerative disease 3 | 383
Rheumatoid Arthritis 3 | 1,170
aldosterone-producing adenoma 3 | 664
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
dermatomyositis 3 | 966
gastric carcinoma 3 | 832
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
non-small cell lung cancer 3 | 2,798
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
Alcohol dependence 2 | 107
Amnestic disorder 2 | 37
Amyloidosis 2 | 68
Amyotrophic Lateral Sclerosis 2 | 432
Bipolar Disorder 2 | 266
Brain Neoplasms 2 | 23
COPD 2 | 116
Cadasil 2 | 10
Cerebrovascular disease 2 | 231
Colorectal Neoplasms 2 | 217
Congenital Heart Defects 2 | 37
Crohn's disease 2 | 304
Down syndrome 2 | 548
Encephalitis 2 | 54
Hajdu-Cheney syndrome 2 | 8
Left ventricular noncompaction 2 | 23
Major Depressive Disorder 2 | 106
Multiple myeloma 2 | 1,327
Myofibrillar myopathy 1 2 | 6
Neuroectodermal Tumor, Primitive 2 | 8
Obesity 2 | 616
Pain agnosia 2 | 99
Pick's disease 2 | 14
Rubinstein-Taybi syndrome 2 | 11
Schizophrenia 2 | 503
Shipyard eye 2 | 14
Squamous cell carcinoma of esophagus 2 | 82
Substance abuse 2 | 55
Uterine Cervical Neoplasm 2 | 21
active Crohn's disease 2 | 918
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis 2 | 1,670
ductal carcinoma in situ 2 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
primary Sjogren syndrome 2 | 788
subependymal giant cell astrocytoma 2 | 2,287
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 32 | 17,994
Cardiovascular System 32 | 17,957
Digestive Tract 32 | 18,472
Endocrine System 32 | 18,511
Female tissues 32 | 18,646
Liver and Pancreas 32 | 18,135
Male tissues 32 | 17,968
Nervous System 32 | 18,560
Respiratory system 32 | 17,483
Skin and soft tissues 32 | 18,114
Urinary Tract 32 | 18,443

Target Family

Non-IDG 17 | 11,969
Enzyme 10 | 4,146
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Signaling by NOTCH2 32 | 32
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.03078 88.8 104
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.15164 12.9 197
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Mastermind-like protein 3 MAML3 Tbio Non-IDG -0.86502 7.03 93
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.69814 48.1 387
Delta-like protein 4 DLL4 Tbio Non-IDG -2.35311 240.0 323
Nicastrin NCSTN Tbio Non-IDG -2.13111 143.4 321
Mastermind-like protein 1 MAML1 Tbio Non-IDG -1.63620 37.7 162
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.55352 421.8 301
Recombining binding protein suppressor of hairless RBPJ Tbio Transcription Factor -2.64922 425.0 221