Development Level

Tbio 30 | 10,625
Tchem 15 | 1,890
Tclin 11 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
increased body weight 3 | 42
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
increased leukocyte cell numbe... 2 | 37
abnormal behavior 1 | 226
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal respiratory quotient 1 | 9
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased effector memory CD4-... 1 | 15
increased grip strength 1 | 83
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
long tibia 1 | 13

Disease

ovarian cancer 34 | 8,484
Cancer 32 | 2,346
glioblastoma 27 | 5,572
medulloblastoma, large-cell 27 | 6,234
osteosarcoma 27 | 7,933
Multiple myeloma 19 | 1,327
psoriasis 19 | 6,685
atypical teratoid / rhabdoid tumor 18 | 4,369
lung cancer 18 | 4,466
pilocytic astrocytoma 17 | 3,086
oligodendroglioma 15 | 2,849
primitive neuroectodermal tumor 15 | 3,031
Breast cancer 14 | 3,094
Primary cutaneous T-cell lymphoma 14 | 24
astrocytoma 14 | 1,493
ependymoma 14 | 2,514
pediatric high grade glioma 14 | 2,712
Mammary Neoplasms 13 | 410
Peripheral T-cell lymphoma 13 | 24
adult high grade glioma 11 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
lung carcinoma 11 | 2,844
malignant mesothelioma 11 | 3,162
Alzheimer's disease 10 | 644
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
invasive ductal carcinoma 10 | 2,950
subependymal giant cell astrocytoma 10 | 2,287
Carcinoma 9 | 2,147
interstitial cystitis 9 | 2,299
juvenile dermatomyositis 9 | 1,189
medulloblastoma 9 | 1,524
acute quadriplegic myopathy 8 | 1,157
astrocytic glioma 8 | 2,241
group 3 medulloblastoma 8 | 2,254
group 4 medulloblastoma 8 | 1,875
primary pancreatic ductal adenocarcinoma 8 | 1,271
Pick disease 7 | 1,893
Rheumatoid Arthritis 7 | 1,160
acute myeloid leukemia 7 | 780
gastric carcinoma 7 | 832
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
tuberculosis 7 | 1,557
ulcerative colitis 7 | 2,087
Adenoid Cystic Carcinoma 6 | 99
Carcinoma, Pancreatic Ductal 6 | 19
adrenocortical carcinoma 6 | 1,427
atypical teratoid/rhabdoid tumor 6 | 1,095
lung adenocarcinoma 6 | 2,713
non-small cell lung cancer 6 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
posterior fossa group B ependymoma 6 | 1,530
sonic hedgehog group medulloblastoma 6 | 1,482
Bladder Neoplasm 5 | 109
Intellectual disability 5 | 573
diabetes mellitus 5 | 1,663
posterior fossa group A ependymoma 5 | 1,511
Crohn's disease 4 | 304
Endometriosis 4 | 535
Lung Neoplasms 4 | 171
Neurodegenerative disease 4 | 383
Squamous cell carcinoma of esophagus 4 | 82
Stevens-Johnson syndrome 4 | 78
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
cystic fibrosis 4 | 1,665
progressive supranuclear palsy 4 | 674
Adams Oliver syndrome 3 | 6
Adams-Oliver syndrome 3 | 13
Alagille syndrome 3 | 15
Amyotrophic Lateral Sclerosis 3 | 431
Carcinoma, Transitional Cell 3 | 31
Colonic Neoplasms 3 | 126
Congenital Heart Defects 3 | 37
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Familial primary pulmonary hypertension 3 | 3
Glaucoma 3 | 134
Heart disease 3 | 279
Hidradenitis suppurativa 3 | 12
IGA Glomerulonephritis 3 | 454
Immune system cancer 3 | 38
Kidney cancer 3 | 118
Lymphoid leukemia 3 | 69
Melanoma 3 | 261
Prostatic Neoplasms 3 | 471
aldosterone-producing adenoma 3 | 664
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
dermatomyositis 3 | 933
ductal carcinoma in situ 3 | 1,745
Atopic dermatitis 2 | 944
Cerebrovascular disease 2 | 231
Contact Dermatitis 2 | 80
Multiple Sclerosis 2 | 498
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 918
chronic rhinosinusitis 2 | 512
inflammatory breast cancer 2 | 404
spina bifida 2 | 1,064

Tissue

Blood and immune system 57 | 17,995
Cardiovascular System 57 | 17,958
Digestive Tract 57 | 18,473
Endocrine System 57 | 18,512
Female tissues 57 | 18,647
Liver and Pancreas 57 | 18,136
Male tissues 57 | 17,969
Nervous System 57 | 18,561
Respiratory system 57 | 17,484
Skin and soft tissues 57 | 18,115
Urinary Tract 57 | 18,444

Target Family

Non-IDG 20 | 11,971
Epigenetic 15 | 242
Enzyme 12 | 4,146
Transcription Factor 9 | 1,400
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH1 in Cancer 57 | 57
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.02060 88.8 104
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.73604 61.8 100
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.88715 67.2 211
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.00652 11.1 153
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84502 678.2 177