Development Level

Tbio 30 | 10,625
Tchem 15 | 1,890
Tclin 11 | 602
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased lean body mass 3 | 195
increased body weight 3 | 42
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
increased leukocyte cell numbe... 2 | 37
abnormal behavior 1 | 226
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal respiratory quotient 1 | 9
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased circulating alkaline... 1 | 119
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased effector memory CD4-... 1 | 15
increased grip strength 1 | 83
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
long tibia 1 | 13

Disease

ovarian cancer 34 | 8,491
Cancer 32 | 2,346
glioblastoma 27 | 5,572
medulloblastoma, large-cell 27 | 6,234
osteosarcoma 27 | 7,933
Multiple myeloma 19 | 1,327
psoriasis 19 | 6,685
atypical teratoid / rhabdoid tumor 18 | 4,369
lung cancer 18 | 4,473
pilocytic astrocytoma 17 | 3,086
oligodendroglioma 15 | 2,849
primitive neuroectodermal tumor 15 | 3,031
Breast cancer 14 | 3,098
Primary cutaneous T-cell lymphoma 14 | 29
astrocytoma 14 | 1,493
ependymoma 14 | 2,514
pediatric high grade glioma 14 | 2,712
Mammary Neoplasms 13 | 410
Peripheral T-cell lymphoma 13 | 24
adult high grade glioma 11 | 2,148
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
lung carcinoma 11 | 2,844
malignant mesothelioma 11 | 3,163
Alzheimer's disease 10 | 644
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
invasive ductal carcinoma 10 | 2,950
subependymal giant cell astrocytoma 10 | 2,287
Carcinoma 9 | 2,147
interstitial cystitis 9 | 2,299
juvenile dermatomyositis 9 | 1,189
medulloblastoma 9 | 1,524
acute myeloid leukemia 8 | 785
acute quadriplegic myopathy 8 | 1,157
astrocytic glioma 8 | 2,241
group 3 medulloblastoma 8 | 2,254
group 4 medulloblastoma 8 | 1,875
primary pancreatic ductal adenocarcinoma 8 | 1,271
Pick disease 7 | 1,893
Rheumatoid Arthritis 7 | 1,170
gastric carcinoma 7 | 832
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
tuberculosis 7 | 1,563
ulcerative colitis 7 | 2,087
Adenoid Cystic Carcinoma 6 | 99
Carcinoma, Pancreatic Ductal 6 | 19
adrenocortical carcinoma 6 | 1,427
atypical teratoid/rhabdoid tumor 6 | 1,095
lung adenocarcinoma 6 | 2,714
non-small cell lung cancer 6 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
posterior fossa group B ependymoma 6 | 1,530
sonic hedgehog group medulloblastoma 6 | 1,482
Bladder Neoplasm 5 | 109
Intellectual disability 5 | 573
diabetes mellitus 5 | 1,663
posterior fossa group A ependymoma 5 | 1,511
Crohn's disease 4 | 304
Endometriosis 4 | 535
Lung Neoplasms 4 | 171
Neurodegenerative disease 4 | 383
Squamous cell carcinoma of esophagus 4 | 82
Stevens-Johnson syndrome 4 | 91
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
cystic fibrosis 4 | 1,670
progressive supranuclear palsy 4 | 674
Adams Oliver syndrome 3 | 6
Adams-Oliver Syndrome 1 3 | 6
Adams-Oliver syndrome 3 | 13
Alagille syndrome 3 | 15
Amyotrophic Lateral Sclerosis 3 | 432
Carcinoma, Transitional Cell 3 | 31
Colonic Neoplasms 3 | 126
Congenital Heart Defects 3 | 37
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Familial primary pulmonary hypertension 3 | 3
Glaucoma 3 | 135
Heart disease 3 | 279
Hidradenitis suppurativa 3 | 12
IGA Glomerulonephritis 3 | 454
Immune system cancer 3 | 38
Kidney cancer 3 | 121
Lymphoid leukemia 3 | 69
Melanoma 3 | 261
Prostatic Neoplasms 3 | 471
aldosterone-producing adenoma 3 | 664
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
Atopic dermatitis 2 | 944
Contact Dermatitis 2 | 80
Multiple Sclerosis 2 | 498
Waldenstrons macroglobulinemia 2 | 764
active Crohn's disease 2 | 918
chronic rhinosinusitis 2 | 512
inflammatory breast cancer 2 | 404
spina bifida 2 | 1,064

Tissue

Blood and immune system 57 | 17,994
Cardiovascular System 57 | 17,957
Digestive Tract 57 | 18,472
Endocrine System 57 | 18,511
Female tissues 57 | 18,646
Liver and Pancreas 57 | 18,135
Male tissues 57 | 17,968
Nervous System 57 | 18,560
Respiratory system 57 | 17,483
Skin and soft tissues 57 | 18,114
Urinary Tract 57 | 18,443

Target Family

Non-IDG 20 | 11,969
Epigenetic 15 | 242
Enzyme 12 | 4,146
Transcription Factor 9 | 1,400
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH1 in Cancer 57 | 57
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.36549 229.4 425
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.03078 88.8 104
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.15164 12.9 197
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Hairy/enhancer-of-split related with YRPW motif-like protein HEYL Tbio Transcription Factor -1.96922 91.5 262
Mastermind-like protein 3 MAML3 Tbio Non-IDG -0.86502 7.03 93
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.69814 48.1 387
Delta-like protein 4 DLL4 Tbio Non-IDG -2.35311 240.0 323