Development Level

Tbio 41 | 10,625
Tchem 18 | 1,890
Tclin 11 | 602
Tdark 2 | 7,003

IMPC Phenotype

decreased lean body mass 4 | 195
preweaning lethality, complete... 4 | 633
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
increased body weight 3 | 42
abnormal behavior 2 | 226
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased grip strength 2 | 123
decreased prepulse inhibition 2 | 52
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
thrombocytopenia 2 | 46
abnormal bone structure 1 | 131
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal respiratory quotient 1 | 9
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 35
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased heart weight 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
long tibia 1 | 13
tremors 1 | 34

Disease

ovarian cancer 40 | 8,491
glioblastoma 36 | 5,572
Cancer 35 | 2,346
osteosarcoma 35 | 7,933
medulloblastoma, large-cell 34 | 6,234
psoriasis 27 | 6,685
atypical teratoid / rhabdoid tumor 26 | 4,369
lung cancer 26 | 4,473
oligodendroglioma 20 | 2,849
Multiple myeloma 19 | 1,327
pilocytic astrocytoma 19 | 3,086
primitive neuroectodermal tumor 19 | 3,031
astrocytoma 18 | 1,493
ependymoma 18 | 2,514
pediatric high grade glioma 18 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
lung carcinoma 17 | 2,844
Breast cancer 16 | 3,098
malignant mesothelioma 16 | 3,163
Mammary Neoplasms 15 | 410
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
Primary cutaneous T-cell lymphoma 14 | 29
interstitial cystitis 14 | 2,299
invasive ductal carcinoma 14 | 2,950
Carcinoma 13 | 2,147
Peripheral T-cell lymphoma 13 | 24
subependymal giant cell astrocytoma 13 | 2,287
Alzheimer's disease 12 | 644
astrocytic glioma 12 | 2,241
pituitary cancer 12 | 1,972
adult high grade glioma 11 | 2,148
group 3 medulloblastoma 11 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
juvenile dermatomyositis 11 | 1,189
non-small cell lung cancer 11 | 2,798
acute quadriplegic myopathy 10 | 1,157
adrenocortical carcinoma 10 | 1,427
group 4 medulloblastoma 10 | 1,875
medulloblastoma 10 | 1,524
ulcerative colitis 10 | 2,087
Pick disease 9 | 1,893
Rheumatoid Arthritis 9 | 1,170
acute myeloid leukemia 9 | 785
gastric carcinoma 9 | 832
pancreatic cancer 9 | 2,300
primary pancreatic ductal adenocarcinoma 9 | 1,271
Carcinoma, Pancreatic Ductal 8 | 19
breast carcinoma 8 | 1,614
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,563
Adenoid Cystic Carcinoma 7 | 99
cystic fibrosis 7 | 1,670
lung adenocarcinoma 7 | 2,714
posterior fossa group A ependymoma 7 | 1,511
atypical teratoid/rhabdoid tumor 6 | 1,095
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
posterior fossa group B ependymoma 6 | 1,530
Amyotrophic Lateral Sclerosis 5 | 432
Bladder Neoplasm 5 | 109
Duchenne muscular dystrophy 5 | 602
Intellectual disability 5 | 573
Squamous cell carcinoma of esophagus 5 | 82
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
colon cancer 5 | 1,475
dermatomyositis 5 | 966
progressive supranuclear palsy 5 | 674
Congenital Heart Defects 4 | 37
Crohn's disease 4 | 304
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Lung Neoplasms 4 | 171
Neurodegenerative disease 4 | 383
Prostatic Neoplasms 4 | 471
Stevens-Johnson syndrome 4 | 91
Alagille syndrome 3 | 15
Atopic dermatitis 3 | 944
Bipolar Disorder 3 | 266
Carcinoma, Transitional Cell 3 | 31
Colonic Neoplasms 3 | 126
Down syndrome 3 | 548
Glaucoma 3 | 135
Heart disease 3 | 279
Immune system cancer 3 | 38
Kidney cancer 3 | 121
Lymphoid leukemia 3 | 69
Melanoma 3 | 261
Obesity 3 | 616
Pain agnosia 3 | 99
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
cutaneous lupus erythematosus 3 | 1,056
esophageal adenocarcinoma 3 | 737
inflammatory breast cancer 3 | 404
non-inflammatory breast cancer 3 | 208
sarcoidosis 3 | 368
spina bifida 3 | 1,064
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 72 | 17,994
Cardiovascular System 72 | 17,957
Digestive Tract 72 | 18,472
Endocrine System 72 | 18,511
Female tissues 72 | 18,646
Liver and Pancreas 72 | 18,135
Male tissues 72 | 17,968
Nervous System 72 | 18,560
Respiratory system 72 | 17,483
Skin and soft tissues 72 | 18,114
Urinary Tract 72 | 18,443

Target Family

Non-IDG 30 | 11,969
Enzyme 16 | 4,146
Epigenetic 15 | 242
Transcription Factor 10 | 1,400
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH1 72 | 72
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.36549 229.4 425
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.03078 88.8 104
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.15164 12.9 197
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84368 678.2 177
Hairy/enhancer-of-split related with YRPW motif-like protein HEYL Tbio Transcription Factor -1.96922 91.5 262
Mastermind-like protein 3 MAML3 Tbio Non-IDG -0.86502 7.03 93
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.69814 48.1 387
Delta-like protein 4 DLL4 Tbio Non-IDG -2.35311 240.0 323