Development Level

Tbio 41 | 10,625
Tchem 18 | 1,890
Tclin 11 | 602
Tdark 2 | 7,003

IMPC Term

decreased lean body mass 4 | 195
preweaning lethality, complete... 4 | 633
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
increased body weight 3 | 42
abnormal behavior 2 | 226
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased grip strength 2 | 123
decreased prepulse inhibition 2 | 52
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
thrombocytopenia 2 | 46
abnormal bone structure 1 | 131
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal respiratory quotient 1 | 9
abnormal sleep behavior 1 | 63
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 35
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased heart weight 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
long tibia 1 | 13
tremors 1 | 34

Disease

ovarian cancer 40 | 8,484
glioblastoma 36 | 5,572
Cancer 35 | 2,346
osteosarcoma 35 | 7,933
medulloblastoma, large-cell 34 | 6,234
psoriasis 27 | 6,685
atypical teratoid / rhabdoid tumor 26 | 4,369
lung cancer 26 | 4,466
oligodendroglioma 20 | 2,849
Multiple myeloma 19 | 1,327
pilocytic astrocytoma 19 | 3,086
primitive neuroectodermal tumor 19 | 3,031
astrocytoma 18 | 1,493
ependymoma 18 | 2,514
pediatric high grade glioma 18 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
lung carcinoma 17 | 2,844
Breast cancer 16 | 3,094
malignant mesothelioma 16 | 3,162
Mammary Neoplasms 15 | 410
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
Primary cutaneous T-cell lymphoma 14 | 24
interstitial cystitis 14 | 2,299
invasive ductal carcinoma 14 | 2,950
Carcinoma 13 | 2,147
Peripheral T-cell lymphoma 13 | 24
subependymal giant cell astrocytoma 13 | 2,287
Alzheimer's disease 12 | 644
astrocytic glioma 12 | 2,241
pituitary cancer 12 | 1,972
adult high grade glioma 11 | 2,148
group 3 medulloblastoma 11 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
juvenile dermatomyositis 11 | 1,189
non-small cell lung cancer 11 | 2,798
acute quadriplegic myopathy 10 | 1,157
adrenocortical carcinoma 10 | 1,427
group 4 medulloblastoma 10 | 1,875
medulloblastoma 10 | 1,524
ulcerative colitis 10 | 2,087
Pick disease 9 | 1,893
Rheumatoid Arthritis 9 | 1,160
gastric carcinoma 9 | 832
pancreatic cancer 9 | 2,300
primary pancreatic ductal adenocarcinoma 9 | 1,271
Carcinoma, Pancreatic Ductal 8 | 19
acute myeloid leukemia 8 | 780
breast carcinoma 8 | 1,614
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,557
Adenoid Cystic Carcinoma 7 | 99
cystic fibrosis 7 | 1,665
lung adenocarcinoma 7 | 2,713
posterior fossa group A ependymoma 7 | 1,511
atypical teratoid/rhabdoid tumor 6 | 1,095
diabetes mellitus 6 | 1,663
ductal carcinoma in situ 6 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
posterior fossa group B ependymoma 6 | 1,530
Amyotrophic Lateral Sclerosis 5 | 431
Bladder Neoplasm 5 | 109
Duchenne muscular dystrophy 5 | 602
Intellectual disability 5 | 573
Squamous cell carcinoma of esophagus 5 | 82
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
colon cancer 5 | 1,475
dermatomyositis 5 | 933
progressive supranuclear palsy 5 | 674
Congenital Heart Defects 4 | 37
Crohn's disease 4 | 304
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Lung Neoplasms 4 | 171
Neurodegenerative disease 4 | 383
Prostatic Neoplasms 4 | 471
Stevens-Johnson syndrome 4 | 78
Alagille syndrome 3 | 15
Atopic dermatitis 3 | 944
Bipolar Disorder 3 | 266
Carcinoma, Transitional Cell 3 | 31
Colonic Neoplasms 3 | 126
Down syndrome 3 | 548
Glaucoma 3 | 134
Heart disease 3 | 279
Immune system cancer 3 | 38
Kidney cancer 3 | 118
Lymphoid leukemia 3 | 69
Melanoma 3 | 261
Obesity 3 | 616
Pain agnosia 3 | 99
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
cutaneous lupus erythematosus 3 | 1,056
esophageal adenocarcinoma 3 | 737
inflammatory breast cancer 3 | 404
non-inflammatory breast cancer 3 | 208
sarcoidosis 3 | 358
spina bifida 3 | 1,064
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 72 | 17,995
Cardiovascular System 72 | 17,958
Digestive Tract 72 | 18,473
Endocrine System 72 | 18,512
Female tissues 72 | 18,647
Liver and Pancreas 72 | 18,136
Male tissues 72 | 17,969
Nervous System 72 | 18,561
Respiratory system 72 | 17,484
Skin and soft tissues 72 | 18,115
Urinary Tract 72 | 18,444

Target Family

Non-IDG 30 | 11,971
Enzyme 16 | 4,146
Epigenetic 15 | 242
Transcription Factor 10 | 1,400
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH1 72 | 72
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.02060 88.8 104
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Mastermind-like protein 2 MAML2 Tbio Non-IDG -1.73604 61.8 100
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.59708 45.6 159
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.88715 67.2 211