Development Level

Tbio 47 | 11,651
Tchem 13 | 1,388
Tclin 11 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased body weight 2 | 161
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating phosphat... 2 | 26
increased startle reflex 2 | 112
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal eating behavior 1 | 1
abnormal embryo turning 1 | 31
abnormal esophagus morphology 1 | 5
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body temperature 1 | 2
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 52 | 11,493
ovarian cancer 40 | 8,520
Cancer 39 | 2,499
glioblastoma 36 | 5,792
osteosarcoma 35 | 7,950
medulloblastoma, large-cell 33 | 6,241
atypical teratoid / rhabdoid tumor 29 | 5,112
lung cancer 29 | 4,740
psoriasis 27 | 6,694
ependymoma 24 | 4,679
group 3 medulloblastoma 23 | 4,104
Breast cancer 22 | 3,578
oligodendroglioma 20 | 2,850
adult high grade glioma 19 | 3,801
Multiple myeloma 18 | 1,332
malignant mesothelioma 18 | 3,232
primitive neuroectodermal tumor 18 | 3,035
Astrocytoma, Pilocytic 17 | 3,081
lung carcinoma 17 | 2,843
astrocytoma 16 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
astrocytic glioma 15 | 2,597
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Primary cutaneous T-cell lymphoma 14 | 29
interstitial cystitis 14 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
subependymal giant cell astrocytoma 14 | 2,287
Peripheral T-cell lymphoma 13 | 25
invasive ductal carcinoma 13 | 2,951
tuberculosis 13 | 2,010
Alzheimer's disease 12 | 658
Kidney cancer 12 | 2,613
Schizophrenia 12 | 1,160
pituitary cancer 12 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
juvenile dermatomyositis 11 | 1,187
non-small cell lung cancer 11 | 2,890
Mental Depression 9 | 333
Rheumatoid arthritis 9 | 1,191
acute myeloid leukemia 9 | 783
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
gastric carcinoma 9 | 807
pancreatic cancer 9 | 2,398
pediatric high grade glioma 9 | 1,064
ulcerative colitis 9 | 1,819
Bipolar Disorder 8 | 666
Carcinoma, Pancreatic Ductal 8 | 20
Pick disease 8 | 1,894
breast carcinoma 8 | 1,638
primary pancreatic ductal adenocarcinoma 8 | 1,109
Adenoid Cystic Carcinoma 7 | 99
Carcinoma, Adenoid Cystic 7 | 99
cystic fibrosis 7 | 1,696
lung adenocarcinoma 7 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Amyotrophic lateral sclerosis 6 | 451
Carcinoma, Squamous Cell 6 | 110
Cataract 6 | 297
Depressive disorder 6 | 409
Failure to gain weight 6 | 365
Immune system cancer 6 | 140
Lens Opacities 6 | 231
Lymphoid leukemia 6 | 160
Mood Disorders 6 | 184
Pediatric failure to thrive 6 | 365
Seizures 6 | 596
Strabismus 6 | 270
diabetes mellitus 6 | 1,728
ductal carcinoma in situ 6 | 1,745
group 4 medulloblastoma 6 | 1,855
medulloblastoma 6 | 720
Bladder Neoplasm 5 | 112
Brachydactyly 5 | 156
Epilepsy 5 | 792
Esophageal Squamous Cell Carcinoma 5 | 77
Intellectual disability 5 | 1,016
Liver Cirrhosis 5 | 181
Squamous cell carcinoma 5 | 129
Squamous cell carcinoma of esophagus 5 | 77
Syndactyly 5 | 88
Urinary Bladder Neoplasms 5 | 114
Vascular disease 5 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
colon cancer 5 | 1,478
progressive supranuclear palsy 5 | 676
Bilateral fifth finger clinodactyly 4 | 110
Cerebrovascular disease 4 | 238
Crohn's disease 4 | 321
Curvature of little finger 4 | 110
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Endometriosis 4 | 540
Glaucoma 4 | 239
Prostatic Neoplasms 4 | 495
Unipolar Depression 4 | 250
Ventricular Septal Defects 4 | 119
aldosterone-producing adenoma 4 | 665
dermatomyositis 4 | 966

Tissue

Blood and immune system 72 | 16,909
Cardiovascular System 72 | 15,192
Digestive Tract 72 | 17,369
Endocrine System 72 | 18,159
Female tissues 72 | 17,400
Liver and Pancreas 72 | 16,750
Male tissues 72 | 17,142
Nervous System 72 | 16,725
Respiratory system 72 | 16,393
Skin and soft tissues 72 | 17,230
Urinary Tract 72 | 16,678

Target Family

Non-IDG 30 | 12,091
Enzyme 16 | 4,145
Epigenetic 15 | 242
Transcription Factor 10 | 1,400
Kinase 1 | 634

Reactome Pathway

Signaling by NOTCH1 72 | 72
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
Nuclear receptor corepressor 2 NCOR2 Tchem Transcription Factor -2.83392 645.1 189
Gamma-secretase subunit APH-1B APH1B Tbio Enzyme -1.17035 13.6 56
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
Beta-arrestin-1 ARRB1 Tbio Non-IDG -2.63877 418.5 490
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
SNW domain-containing protein 1 SNW1 Tbio Non-IDG -1.59688 46.1 88
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201