Development Level

Tbio 15 | 11,445
Tchem 4 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
increased circulating potassiu... 1 | 29
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
thrombocytopenia 1 | 56

Disease

Carcinoma 11 | 11,493
ovarian cancer 10 | 8,520
Cancer 9 | 2,499
osteosarcoma 9 | 7,950
psoriasis 8 | 6,694
Right atrial isomerism 7 | 29
group 3 medulloblastoma 7 | 4,104
Visceral heterotaxy 6 | 14
Congenital heart disease 5 | 93
Situs ambiguus 5 | 25
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
Heterotaxy Syndrome 4 | 5
Holoprosencephaly 4 | 56
Kidney cancer 4 | 2,613
Situs ambiguous 4 | 8
lung cancer 4 | 4,740
subependymal giant cell astrocytoma 4 | 2,287
Alobar Holoprosencephaly 3 | 14
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Craniofacial Abnormalities 3 | 151
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Lobar Holoprosencephaly 3 | 20
Semilobar Holoprosencephaly 3 | 14
Situs Inversus 3 | 65
Ventricular Septal Defects 3 | 119
adult high grade glioma 3 | 3,801
dermatomyositis 3 | 966
ependymoma 3 | 4,679
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
Aortic coarctation 2 | 30
Astigmatism 2 | 54
Atrial Septal Defects 2 | 85
Autosomal recessive predisposition 2 | 1,442
Brachydactyly 2 | 156
CONOTRUNCAL HEART MALFORMATIONS (disorder) 2 | 6
Cholecystitis 2 | 18
Chronic fatigue syndrome 2 | 25
Cleft Palate 2 | 271
Congenital Camptodactyly 2 | 40
Conotruncal Heart Malformations 2 | 10
Cryptorchidism 2 | 296
Discordant ventriculoarterial connection 2 | 17
Double Outlet Right Ventricle 2 | 11
Hypertensive disease 2 | 292
Increase in blood pressure 2 | 119
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Liver disease 2 | 237
Loeys-Dietz syndrome 2 | 23
Multiple synostoses syndrome 2 | 9
Myopathy 2 | 185
Myopia 2 | 176
Orbital separation excessive 2 | 244
Osteoarthritis 2 | 184
Peyronie's disease 2 | 9
Pneumonia 2 | 174
Pulmonary Fibrosis 2 | 106
Systemic scleroderma 2 | 60
Tetralogy of Fallot 2 | 63
Transposition of Great Vessels 2 | 2
Ureteral obstruction 2 | 33
Vascular disease 2 | 319
Ventricular Remodeling 2 | 5
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
fibroadenoma 2 | 559
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Abnormal nasal morphology 1 | 16
Appendicitis 1 | 15
Cutis marmorata 1 | 32
Cystic medial necrosis of aorta 1 | 13
Dyspnea on exertion 1 | 24
Dyspnea, Paroxysmal 1 | 13
Hepatitis, Chronic 1 | 23
Impaired left ventricular function 1 | 16
Invasive Ductal Breast Carcinoma 1 | 9
Left-Sided Heart Failure 1 | 16
Loeys-Dietz Aortic Aneurysm Syndrome 1 | 13
Platyspondyly 1 | 56
Scimitar syndrome 1 | 7
Simple syndactyly of toes, first web space 1 | 23
Sinusitis 1 | 65

Tissue

Digestive Tract 19 | 17,369
Male tissues 19 | 17,142
Skin and soft tissues 19 | 17,230
Endocrine System 18 | 18,159
Liver and Pancreas 18 | 16,750
Nervous System 18 | 16,725
Female tissues 17 | 17,400
Urinary Tract 17 | 16,678
Blood and immune system 15 | 16,909
Respiratory system 15 | 16,393
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 10 | 12,091
Transcription Factor 5 | 1,400
Kinase 3 | 634
Enzyme 2 | 4,145

Reactome Pathway

Signaling by NODAL 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dr1-associated corepressor DRAP1 Tbio Non-IDG -1.11644 10.8 122
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Putative teratocarcinoma-derived growth factor 3 TDGF1P3 Tdark Non-IDG -1.99746 160.4 0
Cryptic protein CFC1 Tbio Non-IDG -1.89131 76.4 159
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Embryonic growth/differentiation factor 1 GDF1 Tbio Non-IDG -2.00590 102.6 64
DAN domain family member 5 DAND5 Tbio Non-IDG -2.95138 850.2 112
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Cerberus CER1 Tbio Non-IDG -2.32331 194.4 188
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303