Development Level

Tbio 39 | 10,625
Tchem 23 | 1,890
Tclin 3 | 602
Tdark 2 | 7,003

IMPC Term

abnormal behavior 3 | 226
decreased body length 2 | 108
decreased total body fat amoun... 2 | 186
preweaning lethality, complete... 2 | 633
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 23
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased vertical activity 1 | 22
enlarged heart 1 | 111
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased NK T cell number 1 | 11
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased startle reflex 1 | 38
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 44 | 8,484
osteosarcoma 36 | 7,933
Cancer 33 | 2,346
glioblastoma 27 | 5,572
psoriasis 27 | 6,685
Carcinoma 25 | 2,147
lung cancer 25 | 4,466
medulloblastoma, large-cell 24 | 6,234
Breast cancer 21 | 3,094
invasive ductal carcinoma 20 | 2,950
atypical teratoid / rhabdoid tumor 19 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
pancreatic cancer 19 | 2,300
non-small cell lung cancer 18 | 2,798
oligodendroglioma 18 | 2,849
lung adenocarcinoma 17 | 2,713
malignant mesothelioma 17 | 3,162
pediatric high grade glioma 16 | 2,712
primary pancreatic ductal adenocarcinoma 15 | 1,271
ulcerative colitis 15 | 2,087
breast carcinoma 14 | 1,614
ependymoma 14 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
juvenile dermatomyositis 14 | 1,189
astrocytoma 13 | 1,493
group 4 medulloblastoma 13 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
pilocytic astrocytoma 13 | 3,086
interstitial cystitis 12 | 2,299
lung carcinoma 12 | 2,844
primitive neuroectodermal tumor 12 | 3,031
Multiple myeloma 11 | 1,327
Pick disease 11 | 1,893
cystic fibrosis 11 | 1,665
dermatomyositis 11 | 933
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
astrocytic glioma 10 | 2,241
subependymal giant cell astrocytoma 10 | 2,287
Rheumatoid Arthritis 9 | 1,160
diabetes mellitus 9 | 1,663
posterior fossa group A ependymoma 9 | 1,511
sonic hedgehog group medulloblastoma 9 | 1,482
Liver carcinoma 8 | 217
Squamous cell carcinoma 8 | 94
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
non-small cell lung carcinoma 8 | 413
pituitary cancer 8 | 1,972
Noonan Syndrome 7 | 33
acute quadriplegic myopathy 7 | 1,157
gastric carcinoma 7 | 832
group 3 medulloblastoma 7 | 2,254
progressive supranuclear palsy 7 | 674
tuberculosis 7 | 1,557
Neoplasm Invasiveness 6 | 127
Neuroblastoma 6 | 78
Prostatic Neoplasms 6 | 471
Stomach Neoplasms 6 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
fibroadenoma 6 | 557
nasopharyngeal carcinoma 6 | 1,056
non primary Sjogren syndrome sicca 6 | 840
Colorectal Neoplasms 5 | 217
Duchenne muscular dystrophy 5 | 602
Immune system cancer 5 | 38
Leukemia, Myelocytic, Acute 5 | 113
Lymphoid leukemia 5 | 69
Mammary Neoplasms 5 | 410
Neoplasm Metastasis 5 | 138
Schizophrenia 5 | 501
adult high grade glioma 5 | 2,148
colon cancer 5 | 1,475
medulloblastoma 5 | 1,524
spina bifida 5 | 1,064
Adenocarcinoma 4 | 115
Adenoma 4 | 165
Animal Mammary Neoplasms 4 | 136
Autistic Disorder 4 | 320
Bladder Neoplasm 4 | 109
Colonic Neoplasms 4 | 126
Crohn's disease 4 | 304
Endometriosis 4 | 535
Epidermolysis bullosa 4 | 21
Heart disease 4 | 279
Intellectual disability 4 | 573
Junctional epidermolysis bullosa 4 | 9
Juvenile Myelomonocytic Leukemia 4 | 21
Kidney cancer 4 | 118
Kidney disease 4 | 396
Liver neoplasms 4 | 109
Lung Neoplasms 4 | 171
Mammary Neoplasms, Experimental 4 | 150
Pancreatitis 4 | 97
Parkinson's disease 4 | 364
Vascular disease 4 | 281
active ulcerative colitis 4 | 477
acute myeloid leukemia 4 | 780
glioblastoma multiforme 4 | 347
ovarian neoplasm 4 | 97
tuberculosis and treatment for 6 months 4 | 686

Tissue

Blood and immune system 67 | 17,995
Cardiovascular System 67 | 17,958
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Liver and Pancreas 67 | 18,136
Male tissues 67 | 17,969
Nervous System 67 | 18,561
Respiratory system 67 | 17,484
Skin and soft tissues 67 | 18,115
Urinary Tract 67 | 18,444

Target Family

Non-IDG 39 | 11,971
Enzyme 22 | 4,146
Kinase 5 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by MET 67 | 67
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Laminin subunit alpha-2 LAMA2 Tbio Non-IDG -2.48634 321.9 131
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Tensin-4 TNS4 Tbio Non-IDG -1.16707 13.6 124
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Laminin subunit gamma-1 LAMC1 Tchem Non-IDG -1.73437 53.6 239
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971