Development Level

Tbio 265 | 10,625
Tchem 149 | 1,890
Tclin 79 | 602
Tdark 8 | 7,003

IMPC Term

preweaning lethality, complete... 20 | 633
decreased total body fat amoun... 10 | 186
enlarged heart 10 | 111
decreased body weight 9 | 174
decreased bone mineral content 7 | 157
decreased lean body mass 7 | 195
embryonic lethality prior to t... 6 | 187
preweaning lethality, incomple... 6 | 260
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
abnormal seminal vesicle morph... 5 | 47
decreased circulating glucose ... 5 | 121
decreased lumbar vertebrae num... 5 | 62
increased mean corpuscular hem... 5 | 93
increased mean corpuscular vol... 5 | 91
thrombocytopenia 5 | 46
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased heart weight 4 | 44
increased lean body mass 4 | 107
abnormal femur morphology 3 | 14
abnormal retinal pigmentation 3 | 61
decreased body length 3 | 108
decreased caudal vertebrae num... 3 | 49
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
decreased neutrophil cell numb... 3 | 37
enlarged epididymis 3 | 27
enlarged lymph nodes 3 | 27
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased grip strength 3 | 83
male infertility 3 | 62
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal lens morphology 2 | 73
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
cataract 2 | 26
decreased T cell number 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating free fat... 2 | 39
decreased circulating total pr... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased startle reflex 2 | 48
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
embryonic lethality prior to o... 2 | 148
enlarged spleen 2 | 26
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating phosphat... 2 | 24
increased exploration in new e... 2 | 56
increased leukocyte cell numbe... 2 | 37
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
limb grasping 2 | 35
short tibia 2 | 82
small superior vagus ganglion 2 | 20
small testis 2 | 37
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
corneal opacity 1 | 25
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
female infertility 1 | 34
increased NK cell number 1 | 19
increased blood uric acid leve... 1 | 5
increased circulating choleste... 1 | 53
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
tremors 1 | 34

Disease

ovarian cancer 268 | 8,484
psoriasis 258 | 6,685
osteosarcoma 254 | 7,933
Cancer 245 | 2,346
glioblastoma 215 | 5,572
lung cancer 211 | 4,466
medulloblastoma, large-cell 184 | 6,234
malignant mesothelioma 139 | 3,162
lung carcinoma 136 | 2,844
ulcerative colitis 134 | 2,087
pilocytic astrocytoma 130 | 3,086
atypical teratoid / rhabdoid tumor 126 | 4,369
interstitial cystitis 125 | 2,299
invasive ductal carcinoma 125 | 2,950
Breast cancer 119 | 3,094
non-small cell lung cancer 110 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 109 | 3,289
lung adenocarcinoma 109 | 2,713
subependymal giant cell astrocytoma 106 | 2,287
pancreatic cancer 105 | 2,300
tuberculosis 103 | 1,557
pediatric high grade glioma 102 | 2,712
oligodendroglioma 93 | 2,849
diabetes mellitus 91 | 1,663
Rheumatoid Arthritis 89 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 85 | 2,956
cystic fibrosis 84 | 1,665
ependymoma 84 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 84 | 2,988
Carcinoma 80 | 2,147
pituitary cancer 79 | 1,972
Asthma 76 | 349
astrocytoma 76 | 1,493
Multiple myeloma 75 | 1,327
primitive neuroectodermal tumor 73 | 3,031
ductal carcinoma in situ 71 | 1,745
cutaneous lupus erythematosus 70 | 1,056
astrocytic glioma 69 | 2,241
Arthritis 67 | 248
breast carcinoma 65 | 1,614
group 4 medulloblastoma 65 | 1,875
adult high grade glioma 63 | 2,148
colon cancer 62 | 1,475
Multiple Sclerosis 60 | 498
group 3 medulloblastoma 59 | 2,254
posterior fossa group A ependymoma 59 | 1,511
juvenile dermatomyositis 57 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,795
Hypersensitivity reaction type II disease 55 | 235
primary pancreatic ductal adenocarcinoma 54 | 1,271
Inflammatory bowel disease 53 | 142
Mammary Neoplasms 53 | 410
Pick disease 53 | 1,893
gastric carcinoma 50 | 832
Kidney disease 49 | 396
Lung disease 49 | 132
medulloblastoma 49 | 1,524
primary Sjogren syndrome 49 | 789
adrenocortical carcinoma 48 | 1,427
Obesity 47 | 616
Prostatic Neoplasms 45 | 471
Vascular disease 45 | 281
dermatomyositis 45 | 933
Atopic dermatitis 44 | 944
Atherosclerosis 42 | 275
Lung Neoplasms 41 | 171
esophageal adenocarcinoma 40 | 737
mucosa-associated lymphoid tissue lymphoma 39 | 480
spina bifida 39 | 1,064
Pneumonia 38 | 133
nasopharyngeal carcinoma 38 | 1,056
Alzheimer's disease 37 | 644
Dermatitis 37 | 107
Heart disease 37 | 279
Schizophrenia 37 | 501
Stomach Neoplasms 37 | 282
non-small cell lung carcinoma 37 | 413
Myocardial Ischemia 36 | 169
Reperfusion Injury 36 | 84
Waldenstrons macroglobulinemia 36 | 765
Endometriosis 35 | 535
IGA Glomerulonephritis 35 | 454
active Crohn's disease 35 | 918
acute quadriplegic myopathy 35 | 1,157
Inflammation 34 | 109
Liver carcinoma 34 | 217
Allergic hypersensitivity disease 33 | 123
Brain Ischemia 33 | 87
Liver disease 33 | 219
Parkinson's disease 33 | 364
hepatocellular carcinoma 33 | 532
pancreatic carcinoma 33 | 567
Eosinophilia 32 | 65
Neoplasm Invasiveness 32 | 127
periodontitis 32 | 269
sarcoidosis 32 | 358
Neoplasm Metastasis 31 | 138
atypical teratoid/rhabdoid tumor 31 | 1,095
Crohn's disease 30 | 304
posterior fossa group B ependymoma 30 | 1,530

Tissue

Nervous System 497 | 18,561
Endocrine System 496 | 18,512
Female tissues 496 | 18,647
Digestive Tract 494 | 18,473
Urinary Tract 494 | 18,444
Blood and immune system 491 | 17,995
Liver and Pancreas 491 | 18,136
Skin and soft tissues 490 | 18,115
Cardiovascular System 485 | 17,958
Male tissues 481 | 17,969
Respiratory system 476 | 17,484

Target Family

Non-IDG 281 | 11,971
Enzyme 110 | 4,146
Kinase 67 | 634
Transcription Factor 25 | 1,400
GPCR 8 | 406
Ion Channel 5 | 341
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

Reactome Pathway

Signaling by Interleukins 501 | 501
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65