Development Level

Tbio 270 | 11,651
Tchem 113 | 1,388
Tclin 59 | 612
Tdark 6 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 17 | 499
abnormal seminal vesicle morph... 10 | 114
enlarged heart 10 | 210
decreased vertical activity 8 | 208
male infertility 8 | 123
decreased total body fat amoun... 7 | 207
increased neutrophil cell numb... 7 | 46
abnormal heart morphology 6 | 162
decreased circulating creatini... 6 | 39
embryonic lethality prior to t... 6 | 278
increased mean corpuscular hem... 6 | 96
increased monocyte cell number 6 | 63
abnormal bone structure 5 | 187
decreased circulating glucose ... 5 | 126
decreased mean corpuscular vol... 5 | 79
embryonic lethality prior to o... 5 | 239
abnormal retina morphology 4 | 71
abnormal sleep behavior 4 | 70
abnormal spleen morphology 4 | 55
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
short tibia 4 | 97
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal epididymis morphology 3 | 42
decreased circulating insulin ... 3 | 76
decreased hemoglobin content 3 | 68
decreased mean corpuscular hem... 3 | 50
enlarged epididymis 3 | 31
enlarged lymph nodes 3 | 37
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
increased leukocyte cell numbe... 3 | 47
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal eye anterior chamber ... 2 | 9
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal humerus morphology 2 | 11
abnormal kidney morphology 2 | 65
abnormal lung morphology 2 | 26
abnormal skin morphology 2 | 50
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating bilirubi... 2 | 19
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 31
decreased startle reflex 2 | 75
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased large unstained cell... 2 | 5
increased lymphocyte cell numb... 2 | 32
increased spleen weight 2 | 10
abnormal cornea morphology 1 | 31
abnormal optic disc morphology 1 | 10
abnormal vertebrae morphology 1 | 18
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased neutrophil cell numb... 1 | 42
increased blood uric acid leve... 1 | 5
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased startle reflex 1 | 112
vertebral fusion 1 | 23

Disease

Carcinoma 263 | 11,493
ovarian cancer 251 | 8,520
psoriasis 245 | 6,694
Cancer 234 | 2,499
osteosarcoma 220 | 7,950
glioblastoma 206 | 5,792
lung cancer 192 | 4,740
medulloblastoma, large-cell 166 | 6,241
malignant mesothelioma 136 | 3,232
atypical teratoid / rhabdoid tumor 134 | 5,112
lung carcinoma 125 | 2,843
ependymoma 124 | 4,679
Breast cancer 118 | 3,578
adult high grade glioma 116 | 3,801
tuberculosis 116 | 2,010
ulcerative colitis 111 | 1,819
interstitial cystitis 109 | 2,312
Astrocytoma, Pilocytic 106 | 3,081
invasive ductal carcinoma 104 | 2,951
non-small cell lung cancer 98 | 2,890
diabetes mellitus 95 | 1,728
subependymal giant cell astrocytoma 95 | 2,287
Rheumatoid arthritis 94 | 1,191
pancreatic cancer 94 | 2,398
group 3 medulloblastoma 92 | 4,104
lung adenocarcinoma 88 | 2,716
Asthma 86 | 385
Schizophrenia 86 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,291
Multiple myeloma 81 | 1,332
Arthritis 77 | 290
intraductal papillary-mucinous carcinoma (IPMC) 77 | 2,989
cystic fibrosis 76 | 1,696
cutaneous lupus erythematosus 70 | 1,057
Liver Cirrhosis, Experimental 68 | 769
primitive neuroectodermal tumor 68 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 65 | 2,955
oligodendroglioma 65 | 2,850
pituitary cancer 65 | 1,972
Inflammatory bowel disease 64 | 151
Multiple Sclerosis 63 | 540
group 4 medulloblastoma 63 | 1,855
breast carcinoma 62 | 1,638
Hypersensitivity reaction type II disease 61 | 253
Kidney cancer 60 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,962
juvenile dermatomyositis 59 | 1,187
astrocytic glioma 57 | 2,597
astrocytoma 57 | 1,146
ductal carcinoma in situ 56 | 1,745
Lung disease 55 | 142
Vascular disease 55 | 319
dermatomyositis 54 | 966
colon cancer 53 | 1,478
Kidney disease 50 | 430
Pneumonia 50 | 174
Obesity 49 | 678
primary Sjogren syndrome 49 | 735
Pick disease 47 | 1,894
Autosomal recessive predisposition 46 | 1,442
Waldenstrons macroglobulinemia 46 | 765
Dermatitis 44 | 157
Prostatic Neoplasms 44 | 495
Atopic dermatitis 43 | 952
Breast Neoplasms 43 | 445
Depressive disorder 43 | 409
acute quadriplegic myopathy 43 | 1,158
Mammary Neoplasms 42 | 425
adrenocortical carcinoma 42 | 1,428
primary pancreatic ductal adenocarcinoma 42 | 1,109
Alzheimer's disease 41 | 658
Bipolar Disorder 41 | 666
Atherosclerosis 40 | 291
Brain Ischemia 39 | 110
Inflammation 39 | 120
Hypertension 38 | 396
Myocardial Ischemia 38 | 169
Reperfusion Injury 38 | 86
nasopharyngeal carcinoma 38 | 1,058
Allergic hypersensitivity disease 37 | 126
Anemia 37 | 365
Liver disease 36 | 237
Lung Neoplasms 36 | 232
active Crohn's disease 36 | 922
active ulcerative colitis 36 | 764
esophageal adenocarcinoma 36 | 737
pediatric high grade glioma 36 | 1,064
Endometriosis 35 | 540
Heart disease 35 | 306
Stomach Neoplasms 35 | 300
Fever 34 | 138
Hypertensive disease 34 | 292
Mental Depression 34 | 333
Neoplasm Metastasis 34 | 168
hepatocellular carcinoma 34 | 547
periodontitis 34 | 293
Neoplasm Invasiveness 33 | 161
Osteoporosis 33 | 363
gastric carcinoma 33 | 807
mucosa-associated lymphoid tissue lymphoma 33 | 484

Tissue

Blood and immune system 438 | 16,909
Digestive Tract 436 | 17,369
Endocrine System 436 | 18,159
Skin and soft tissues 435 | 17,230
Female tissues 431 | 17,400
Urinary Tract 431 | 16,678
Liver and Pancreas 430 | 16,750
Male tissues 429 | 17,142
Respiratory system 420 | 16,393
Nervous System 414 | 16,725
Cardiovascular System 398 | 15,192

Target Family

Non-IDG 235 | 12,091
Enzyme 109 | 4,145
Kinase 55 | 634
Transcription Factor 36 | 1,400
GPCR 8 | 408
Epigenetic 3 | 242
Nuclear Receptor 2 | 48

Reactome Pathway

Signaling by Interleukins 448 | 448
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Alpha-taxilin TXLNA Tbio Non-IDG -1.08682 11.4 99