Development Level

Tbio 175 | 10,625
Tchem 82 | 1,890
Tclin 44 | 602
Tdark 11 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 19 | 633
decreased body weight 10 | 174
embryonic lethality prior to t... 10 | 187
decreased total body fat amoun... 8 | 186
embryonic lethality prior to o... 7 | 148
decreased circulating choleste... 6 | 85
enlarged heart 6 | 111
abnormal bone structure 5 | 131
decreased circulating HDL chol... 5 | 77
decreased circulating LDL chol... 5 | 37
decreased lean body mass 5 | 195
decreased bone mineral content 4 | 157
decreased circulating alanine ... 4 | 53
decreased grip strength 4 | 123
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular vol... 4 | 50
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
abnormal seminal vesicle morph... 3 | 47
decreased body length 3 | 108
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
decreased mean corpuscular hem... 3 | 19
hypoactivity 3 | 89
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal coat-hair pigmentatio... 2 | 54
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased caudal vertebrae num... 2 | 49
decreased circulating aspartat... 2 | 27
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular hem... 2 | 34
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
enlarged spleen 2 | 26
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
impaired pupillary reflex 2 | 14
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased exploration in new e... 2 | 56
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
limb grasping 2 | 35
male infertility 2 | 62
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
thrombocytosis 2 | 23
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal spleen morphology 1 | 36
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
female infertility 1 | 34
impaired righting response 1 | 19
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 177 | 8,491
osteosarcoma 161 | 7,933
glioblastoma 131 | 5,572
medulloblastoma, large-cell 127 | 6,234
psoriasis 126 | 6,685
Cancer 118 | 2,346
lung cancer 107 | 4,473
atypical teratoid / rhabdoid tumor 93 | 4,369
Breast cancer 74 | 3,098
oligodendroglioma 72 | 2,849
ependymoma 70 | 2,514
pilocytic astrocytoma 69 | 3,086
Carcinoma 67 | 2,147
malignant mesothelioma 67 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,289
invasive ductal carcinoma 63 | 2,950
astrocytic glioma 60 | 2,241
pediatric high grade glioma 59 | 2,712
subependymal giant cell astrocytoma 57 | 2,287
lung adenocarcinoma 56 | 2,714
lung carcinoma 55 | 2,844
Multiple myeloma 54 | 1,327
non-small cell lung cancer 52 | 2,798
primitive neuroectodermal tumor 52 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 50 | 2,956
interstitial cystitis 49 | 2,299
pancreatic cancer 49 | 2,300
ulcerative colitis 45 | 2,087
diabetes mellitus 44 | 1,663
Pick disease 42 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
medulloblastoma 40 | 1,524
astrocytoma 39 | 1,493
pituitary cancer 38 | 1,972
tuberculosis 38 | 1,563
adult high grade glioma 37 | 2,148
cystic fibrosis 37 | 1,670
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
group 3 medulloblastoma 36 | 2,254
breast carcinoma 35 | 1,614
group 4 medulloblastoma 35 | 1,875
ductal carcinoma in situ 34 | 1,745
Rheumatoid Arthritis 30 | 1,170
colon cancer 30 | 1,475
primary pancreatic ductal adenocarcinoma 29 | 1,271
Mammary Neoplasms 26 | 410
Parkinson's disease 24 | 364
Schizophrenia 24 | 503
dermatomyositis 24 | 966
Waldenstrons macroglobulinemia 23 | 764
posterior fossa group B ependymoma 23 | 1,530
juvenile dermatomyositis 22 | 1,189
adrenocortical carcinoma 21 | 1,427
non-small cell lung carcinoma 21 | 413
spina bifida 21 | 1,064
Intellectual disability 20 | 573
Liver carcinoma 20 | 217
Alzheimer's disease 19 | 644
Lung Neoplasms 19 | 171
Obesity 19 | 616
Renal Cell Carcinoma 19 | 199
Stomach Neoplasms 19 | 282
cutaneous lupus erythematosus 19 | 1,056
esophageal adenocarcinoma 19 | 737
gastric carcinoma 19 | 832
sonic hedgehog group medulloblastoma 19 | 1,482
atypical teratoid/rhabdoid tumor 18 | 1,095
non primary Sjogren syndrome sicca 18 | 840
pancreatic carcinoma 18 | 567
posterior fossa group A ependymoma 18 | 1,511
Autistic Disorder 17 | 320
HIV Infections 17 | 99
Prostatic Neoplasms 17 | 471
tuberculosis and treatment for 6 months 17 | 686
Asthma 16 | 349
Osteoporosis 16 | 259
Polycystic Ovary Syndrome 16 | 334
Vascular disease 16 | 281
hepatocellular carcinoma 16 | 550
Anemia 15 | 252
Noonan Syndrome 15 | 33
Heart disease 14 | 279
Kidney disease 14 | 397
Neoplasm Invasiveness 14 | 127
Squamous cell carcinoma 14 | 96
fibroadenoma 14 | 557
primary Sjogren syndrome 14 | 788
Animal Mammary Neoplasms 13 | 135
Down syndrome 13 | 548
Kidney cancer 13 | 121
Mammary Neoplasms, Experimental 13 | 149
nasopharyngeal carcinoma 13 | 1,056
Adenoma 12 | 165
Diarrhea 12 | 155
Melanoma 12 | 261
Multiple Sclerosis 12 | 498
Myocardial Ischemia 12 | 169
Peripheral Neuropathy 12 | 303
Thrombocytopenia 12 | 105
acute myeloid leukemia 12 | 785

Tissue

Nervous System 312 | 18,560
Digestive Tract 311 | 18,472
Female tissues 311 | 18,646
Urinary Tract 311 | 18,443
Endocrine System 310 | 18,511
Blood and immune system 309 | 17,994
Liver and Pancreas 309 | 18,135
Skin and soft tissues 308 | 18,114
Cardiovascular System 307 | 17,957
Male tissues 306 | 17,968
Respiratory system 300 | 17,483

Target Family

Non-IDG 140 | 11,969
Enzyme 111 | 4,146
Kinase 56 | 634
Ion Channel 5 | 341

Reactome Pathway

Signaling by Insulin receptor 312 | 312
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha CSF2RA Tclin Non-IDG -2.15518 132.8 381