Development Level

Tdark 443 | 6,588
Tbio 420 | 11,445
Tchem 217 | 1,598
Tclin 137 | 613

Collection

GPCR: IDG Consortium (Targets) 63 | 126
GPCR: IDG Consortium (Complete... 12 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 30 | 979
preweaning lethality, incomple... 24 | 499
decreased vertical activity 22 | 208
abnormal behavior 17 | 298
enlarged heart 17 | 210
decreased bone mineral content 14 | 151
increased total body fat amoun... 13 | 134
abnormal heart morphology 12 | 162
decreased total body fat amoun... 12 | 207
hyperactivity 12 | 148
abnormal bone structure 11 | 187
increased lean body mass 11 | 172
decreased body weight 10 | 161
decreased lean body mass 10 | 135
hypoactivity 10 | 132
increased startle reflex 10 | 112
embryonic lethality prior to t... 9 | 278
improved glucose tolerance 9 | 79
increased circulating alkaline... 8 | 122
male infertility 8 | 123
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36
small superior vagus ganglion 8 | 74
abnormal kidney morphology 7 | 65
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
increased bone mineral content 7 | 108
increased circulating sodium l... 7 | 71
abnormal retina morphology 6 | 71
decreased circulating serum al... 6 | 82
abnormal sleep behavior 5 | 70
decreased circulating insulin ... 5 | 76
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
embryonic lethality prior to o... 5 | 239
increased circulating calcium ... 5 | 34
increased circulating choleste... 5 | 66
increased circulating triglyce... 5 | 42
increased fasted circulating g... 5 | 76
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased circulating alanine ... 4 | 47
decreased circulating amylase ... 4 | 28
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
impaired righting response 4 | 26
increased blood urea nitrogen ... 4 | 48
increased circulating creatini... 4 | 38
increased hemoglobin content 4 | 45
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased neutrophil cell numb... 4 | 46
limb grasping 4 | 41
short tibia 4 | 97
thrombocytopenia 4 | 56
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased exploration in new e... 3 | 11
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased red blood cell distr... 3 | 41
edema 3 | 59
impaired pupillary reflex 3 | 26
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased lymphocyte cell numb... 3 | 32
increased monocyte cell number 3 | 63
small kidney 3 | 16
small testis 3 | 58
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
abnormal whole-body plethysmog... 2 | 4
decreased IgE level 2 | 6
decreased T cell number 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating calcium ... 2 | 36
increased blood uric acid leve... 2 | 5
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
microphthalmia 2 | 26
tremors 2 | 39

Disease

Carcinoma 841 | 11,493
psoriasis 355 | 6,694
osteosarcoma 346 | 7,950
medulloblastoma, large-cell 313 | 6,241
ovarian cancer 312 | 8,520
glioblastoma 276 | 5,792
atypical teratoid / rhabdoid tumor 246 | 5,112
lung cancer 234 | 4,740
ependymoma 233 | 4,679
adult high grade glioma 214 | 3,801
Cancer 207 | 2,499
Astrocytoma, Pilocytic 185 | 3,081
diabetes mellitus 185 | 1,728
lung carcinoma 182 | 2,843
group 3 medulloblastoma 170 | 4,104
malignant mesothelioma 162 | 3,232
Breast cancer 159 | 3,578
interstitial cystitis 159 | 2,312
primitive neuroectodermal tumor 159 | 3,035
invasive ductal carcinoma 158 | 2,951
lung adenocarcinoma 157 | 2,716
oligodendroglioma 150 | 2,850
Schizophrenia 149 | 1,160
non-small cell lung cancer 149 | 2,890
astrocytic glioma 145 | 2,597
Kidney cancer 136 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 131 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 130 | 2,955
Obesity 125 | 678
ulcerative colitis 122 | 1,819
subependymal giant cell astrocytoma 118 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,291
pancreatic cancer 112 | 2,398
tuberculosis 112 | 2,010
ductal carcinoma in situ 105 | 1,745
pituitary cancer 104 | 1,972
Bipolar Disorder 99 | 666
Depressive disorder 98 | 409
group 4 medulloblastoma 95 | 1,855
breast carcinoma 94 | 1,638
cystic fibrosis 93 | 1,696
Autosomal recessive predisposition 91 | 1,442
colon cancer 87 | 1,478
Pick disease 83 | 1,894
Hypertension 82 | 396
cutaneous lupus erythematosus 78 | 1,057
Rheumatoid arthritis 76 | 1,191
Mental Depression 74 | 333
Alcoholic Intoxication, Chronic 73 | 289
Asthma 70 | 385
Major Depressive Disorder 64 | 301
Intellectual disability 60 | 1,016
Epilepsy 59 | 792
adrenocortical carcinoma 59 | 1,428
Liver Cirrhosis, Experimental 56 | 769
Mood Disorders 55 | 184
Parkinson's disease 55 | 392
astrocytoma 55 | 1,146
Hypertensive disease 54 | 292
Multiple Sclerosis 54 | 540
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
Seizures 52 | 596
Kidney disease 51 | 430
Melanoma 51 | 711
Unipolar Depression 51 | 250
primary Sjogren syndrome 51 | 735
active ulcerative colitis 47 | 764
pediatric high grade glioma 47 | 1,064
active Crohn's disease 46 | 922
fibroadenoma 45 | 559
Atherosclerosis 44 | 291
Atopic dermatitis 44 | 952
Dull intelligence 44 | 645
Low intelligence 44 | 645
Mental Retardation 44 | 645
Mental deficiency 44 | 645
Poor school performance 44 | 645
primary pancreatic ductal adenocarcinoma 44 | 1,109
Alzheimer's disease 42 | 658
Vascular disease 41 | 319
non primary Sjogren syndrome sicca 41 | 891
spina bifida 41 | 1,074
Endometriosis 40 | 540
juvenile dermatomyositis 40 | 1,187
Autistic Disorder 39 | 364
Pain 39 | 103
nasopharyngeal carcinoma 39 | 1,058
Hypogonadism 38 | 173
Adenoma 37 | 167
Cerebrovascular disease 37 | 238
Coronary artery disease 37 | 268
Pain agnosia 37 | 104
mucosa-associated lymphoid tissue lymphoma 37 | 484
Liver cancer 36 | 604
Migraine 36 | 83
Down syndrome 35 | 499
Prostatic Neoplasms 35 | 495
aldosterone-producing adenoma 35 | 665
esophageal adenocarcinoma 35 | 737
hepatocellular carcinoma 35 | 547

Tissue

Endocrine System 870 | 18,159
Female tissues 760 | 17,400
Digestive Tract 749 | 17,369
Male tissues 737 | 17,142
Nervous System 727 | 16,725
Skin and soft tissues 723 | 17,230
Blood and immune system 721 | 16,909
Urinary Tract 694 | 16,678
Liver and Pancreas 689 | 16,750
Respiratory system 665 | 16,393
Cardiovascular System 574 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 319 | 12,091
GPCR 300 | 408
Enzyme 125 | 4,145
Kinase 48 | 634
Ion Channel 8 | 344
Transcription Factor 1 | 1,400
Transporter 1 | 473

Reactome Pathway

Signaling by GPCR 1,217 | 1,217
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 4F4 OR4F4 Tdark oGPCR 0.00000 45
Olfactory receptor 4C12 OR4C12 Tdark oGPCR 0.31 0.30 74
Olfactory receptor 4K3 OR4K3 Tdark oGPCR 0.00000 0
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Olfactory receptor 6C68 OR6C68 Tdark oGPCR 0.00000 49
Olfactory receptor 2M4 OR2M4 Tdark oGPCR 0.95 0.18 19