Development Level

Tdark 443 | 6,588
Tbio 420 | 11,445
Tchem 217 | 1,598
Tclin 137 | 613

Collection

GPCR: IDG Consortium (Targets) 63 | 126
RFA-RM-18-021 40 | 328
GPCR: IDG Consortium (Complete... 12 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 30 | 979
preweaning lethality, incomple... 24 | 499
decreased vertical activity 22 | 208
abnormal behavior 17 | 298
enlarged heart 17 | 210
decreased bone mineral content 14 | 151
increased total body fat amoun... 13 | 134
abnormal heart morphology 12 | 162
decreased total body fat amoun... 12 | 207
hyperactivity 12 | 148
abnormal bone structure 11 | 187
increased lean body mass 11 | 172
decreased body weight 10 | 161
decreased lean body mass 10 | 135
hypoactivity 10 | 132
increased startle reflex 10 | 112
embryonic lethality prior to t... 9 | 278
improved glucose tolerance 9 | 79
increased circulating alkaline... 8 | 122
male infertility 8 | 123
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36
small superior vagus ganglion 8 | 74
abnormal kidney morphology 7 | 65
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
increased bone mineral content 7 | 108
increased circulating sodium l... 7 | 71
abnormal retina morphology 6 | 71
decreased circulating serum al... 6 | 82
abnormal sleep behavior 5 | 70
decreased circulating insulin ... 5 | 76
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
embryonic lethality prior to o... 5 | 239
increased circulating calcium ... 5 | 34
increased circulating choleste... 5 | 66
increased circulating triglyce... 5 | 42
increased fasted circulating g... 5 | 76
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased circulating alanine ... 4 | 47
decreased circulating amylase ... 4 | 28
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
impaired righting response 4 | 26
increased blood urea nitrogen ... 4 | 48
increased circulating creatini... 4 | 38
increased hemoglobin content 4 | 45
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased neutrophil cell numb... 4 | 46
limb grasping 4 | 41
short tibia 4 | 97
thrombocytopenia 4 | 56
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased exploration in new e... 3 | 11
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased red blood cell distr... 3 | 41
edema 3 | 59
impaired pupillary reflex 3 | 26
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased lymphocyte cell numb... 3 | 32
increased monocyte cell number 3 | 63
small kidney 3 | 16
small testis 3 | 58
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
abnormal whole-body plethysmog... 2 | 4
decreased IgE level 2 | 6
decreased T cell number 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating calcium ... 2 | 36
increased blood uric acid leve... 2 | 5
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
microphthalmia 2 | 26
tremors 2 | 39

Disease

Carcinoma 841 | 11,493
psoriasis 355 | 6,694
osteosarcoma 346 | 7,950
medulloblastoma, large-cell 313 | 6,241
ovarian cancer 312 | 8,520
glioblastoma 276 | 5,792
atypical teratoid / rhabdoid tumor 246 | 5,112
lung cancer 234 | 4,740
ependymoma 233 | 4,679
adult high grade glioma 214 | 3,801
Cancer 207 | 2,499
Astrocytoma, Pilocytic 185 | 3,081
diabetes mellitus 185 | 1,728
lung carcinoma 182 | 2,843
group 3 medulloblastoma 170 | 4,104
malignant mesothelioma 162 | 3,232
Breast cancer 159 | 3,578
interstitial cystitis 159 | 2,312
primitive neuroectodermal tumor 159 | 3,035
invasive ductal carcinoma 158 | 2,951
lung adenocarcinoma 157 | 2,716
oligodendroglioma 150 | 2,850
Schizophrenia 149 | 1,160
non-small cell lung cancer 149 | 2,890
astrocytic glioma 145 | 2,597
Kidney cancer 136 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 131 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 130 | 2,955
Obesity 125 | 678
ulcerative colitis 122 | 1,819
subependymal giant cell astrocytoma 118 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,291
pancreatic cancer 112 | 2,398
tuberculosis 112 | 2,010
ductal carcinoma in situ 105 | 1,745
pituitary cancer 104 | 1,972
Bipolar Disorder 99 | 666
Depressive disorder 98 | 409
group 4 medulloblastoma 95 | 1,855
breast carcinoma 94 | 1,638
cystic fibrosis 93 | 1,696
Autosomal recessive predisposition 91 | 1,442
colon cancer 87 | 1,478
Pick disease 83 | 1,894
Hypertension 82 | 396
cutaneous lupus erythematosus 78 | 1,057
Rheumatoid arthritis 76 | 1,191
Mental Depression 74 | 333
Alcoholic Intoxication, Chronic 73 | 289
Asthma 70 | 385
Major Depressive Disorder 64 | 301
Intellectual disability 60 | 1,016
Epilepsy 59 | 792
adrenocortical carcinoma 59 | 1,428
Liver Cirrhosis, Experimental 56 | 769
Mood Disorders 55 | 184
Parkinson's disease 55 | 392
astrocytoma 55 | 1,146
Hypertensive disease 54 | 292
Multiple Sclerosis 54 | 540
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
Seizures 52 | 596
Kidney disease 51 | 430
Melanoma 51 | 711
Unipolar Depression 51 | 250
primary Sjogren syndrome 51 | 735
active ulcerative colitis 47 | 764
pediatric high grade glioma 47 | 1,064
active Crohn's disease 46 | 922
fibroadenoma 45 | 559
Atherosclerosis 44 | 291
Atopic dermatitis 44 | 952
Dull intelligence 44 | 645
Low intelligence 44 | 645
Mental Retardation 44 | 645
Mental deficiency 44 | 645
Poor school performance 44 | 645
primary pancreatic ductal adenocarcinoma 44 | 1,109
Alzheimer's disease 42 | 658
Vascular disease 41 | 319
non primary Sjogren syndrome sicca 41 | 891
spina bifida 41 | 1,074
Endometriosis 40 | 540
juvenile dermatomyositis 40 | 1,187
Autistic Disorder 39 | 364
Pain 39 | 103
nasopharyngeal carcinoma 39 | 1,058
Hypogonadism 38 | 173
Adenoma 37 | 167
Cerebrovascular disease 37 | 238
Coronary artery disease 37 | 268
Pain agnosia 37 | 104
mucosa-associated lymphoid tissue lymphoma 37 | 484
Liver cancer 36 | 604
Migraine 36 | 83
Down syndrome 35 | 499
Prostatic Neoplasms 35 | 495
aldosterone-producing adenoma 35 | 665
esophageal adenocarcinoma 35 | 737
hepatocellular carcinoma 35 | 547

Tissue

Endocrine System 870 | 18,159
Female tissues 760 | 17,400
Digestive Tract 749 | 17,369
Male tissues 737 | 17,142
Nervous System 727 | 16,725
Skin and soft tissues 723 | 17,230
Blood and immune system 721 | 16,909
Urinary Tract 694 | 16,678
Liver and Pancreas 689 | 16,750
Respiratory system 665 | 16,393
Cardiovascular System 574 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 319 | 12,091
GPCR 300 | 408
Enzyme 125 | 4,145
Kinase 48 | 634
Ion Channel 8 | 344
Transcription Factor 1 | 1,400
Transporter 1 | 473

Reactome Pathway

Signaling by GPCR 1,217 | 1,217
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Proteinase-activated receptor 1 F2R Tclin GPCR -2.78393 551.0 453
Platelet-activating factor receptor PTAFR Tchem GPCR -2.02420 116.1 134
Endothelin-3 EDN3 Tbio Non-IDG -2.96371 794.0 219
Alpha-1D adrenergic receptor ADRA1D Tclin GPCR -2.25789 174.5 120
Melanocortin receptor 3 MC3R Tchem GPCR -2.65556 445.3 202
Histamine H2 receptor HRH2 Tclin GPCR -3.21267 1595.1 244
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378