Development Level

Tbio 467 | 10,625
Tdark 451 | 7,003
Tchem 253 | 1,890
Tclin 159 | 602

Collection

Eligible non-olfactory GPCR Proteins 68 | 143
Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 30 | 633
decreased body weight 16 | 174
decreased lean body mass 15 | 195
decreased bone mineral content 14 | 157
abnormal behavior 13 | 226
abnormal bone structure 13 | 131
preweaning lethality, incomple... 13 | 260
decreased grip strength 10 | 123
decreased total body fat amoun... 9 | 186
decreased circulating alanine ... 8 | 53
decreased circulating choleste... 8 | 85
enlarged heart 8 | 111
abnormal bone mineralization 7 | 55
decreased bone mineral density 7 | 126
decreased circulating HDL chol... 7 | 77
decreased circulating triglyce... 7 | 83
embryonic lethality prior to t... 7 | 187
male infertility 7 | 62
decreased circulating glucose ... 6 | 121
improved glucose tolerance 6 | 56
increased circulating HDL chol... 6 | 63
increased circulating alkaline... 6 | 119
increased total body fat amoun... 6 | 57
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
abnormal retinal pigmentation 5 | 61
decreased body length 5 | 108
decreased circulating LDL chol... 5 | 37
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
hypoactivity 5 | 89
increased heart weight 5 | 37
abnormal coat/hair pigmentatio... 4 | 54
abnormal epididymis morphology 4 | 31
abnormal seminal vesicle morph... 4 | 47
decreased caudal vertebrae num... 4 | 49
decreased circulating insulin ... 4 | 75
decreased fasted circulating g... 4 | 49
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
increased blood urea nitrogen ... 4 | 44
increased circulating calcium ... 4 | 32
increased circulating sodium l... 4 | 71
increased grip strength 4 | 83
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal kidney morphology 3 | 30
abnormal lens morphology 3 | 73
cataract 3 | 26
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased circulating calcium ... 3 | 33
decreased circulating chloride... 3 | 32
decreased circulating creatini... 3 | 31
decreased circulating serum al... 3 | 79
decreased circulating sodium l... 3 | 18
decreased circulating total pr... 3 | 41
decreased hemoglobin content 3 | 53
decreased kidney weight 3 | 7
decreased neutrophil cell numb... 3 | 37
decreased vertical activity 3 | 22
enlarged epididymis 3 | 27
hydrops fetalis 3 | 22
hyperactivity 3 | 108
impaired pupillary reflex 3 | 14
impaired righting response 3 | 19
increased bone mineral content 3 | 92
increased circulating creatini... 3 | 29
increased circulating phosphat... 3 | 24
increased circulating total pr... 3 | 20
increased fasted circulating g... 3 | 68
increased hemoglobin content 3 | 45
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased monocyte cell number 3 | 27
increased or absent threshold ... 3 | 128
increased startle reflex 3 | 38
limb grasping 3 | 35
short tibia 3 | 82
tremors 3 | 34
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal spleen morphology 2 | 36
abnormal vibrissa morphology 2 | 17
cardiovascular system phenotyp... 2 | 35
decreased IgE level 2 | 3
decreased circulating bilirubi... 2 | 14
decreased rib number 2 | 59
impaired glucose tolerance 2 | 52
increased body length 2 | 20
increased body weight 2 | 42
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
small testis 2 | 37
vertebral fusion 2 | 23

Disease

osteosarcoma 412 | 7,933
ovarian cancer 390 | 8,484
psoriasis 387 | 6,685
medulloblastoma, large-cell 364 | 6,234
glioblastoma 316 | 5,572
Cancer 251 | 2,346
lung cancer 251 | 4,466
atypical teratoid / rhabdoid tumor 246 | 4,369
pilocytic astrocytoma 221 | 3,086
lung carcinoma 195 | 2,844
oligodendroglioma 189 | 2,849
diabetes mellitus 186 | 1,663
malignant mesothelioma 183 | 3,162
invasive ductal carcinoma 182 | 2,950
interstitial cystitis 179 | 2,299
lung adenocarcinoma 179 | 2,713
primitive neuroectodermal tumor 176 | 3,031
Breast cancer 172 | 3,094
ependymoma 162 | 2,514
pediatric high grade glioma 161 | 2,712
ulcerative colitis 161 | 2,087
Carcinoma 159 | 2,147
non-small cell lung cancer 156 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 148 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 145 | 2,988
astrocytic glioma 143 | 2,241
subependymal giant cell astrocytoma 143 | 2,287
adult high grade glioma 135 | 2,148
pancreatic cancer 131 | 2,300
pituitary cancer 112 | 1,972
ductal carcinoma in situ 110 | 1,745
breast carcinoma 108 | 1,614
tuberculosis 106 | 1,557
Pick disease 105 | 1,893
medulloblastoma 105 | 1,524
colon cancer 104 | 1,475
cystic fibrosis 104 | 1,665
Obesity 102 | 616
group 4 medulloblastoma 102 | 1,875
astrocytoma 100 | 1,493
Schizophrenia 95 | 501
group 3 medulloblastoma 94 | 2,254
posterior fossa group A ependymoma 86 | 1,511
Rheumatoid Arthritis 85 | 1,160
cutaneous lupus erythematosus 80 | 1,056
posterior fossa group B ependymoma 75 | 1,530
Asthma 73 | 349
Multiple myeloma 68 | 1,327
Parkinson's disease 68 | 364
adrenocortical carcinoma 64 | 1,427
atypical teratoid/rhabdoid tumor 64 | 1,095
sonic hedgehog group medulloblastoma 64 | 1,482
primary pancreatic ductal adenocarcinoma 63 | 1,271
primary Sjogren syndrome 61 | 789
Hypertension 56 | 287
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,795
gastric carcinoma 51 | 832
Multiple Sclerosis 50 | 498
juvenile dermatomyositis 50 | 1,189
Alzheimer's disease 48 | 644
Autistic Disorder 47 | 320
Kidney disease 47 | 396
non primary Sjogren syndrome sicca 47 | 840
active Crohn's disease 46 | 918
esophageal adenocarcinoma 45 | 737
fibroadenoma 45 | 557
spina bifida 45 | 1,064
Epilepsy 44 | 346
Hypertensive disease 44 | 193
Atopic dermatitis 43 | 944
Down syndrome 43 | 548
non-small cell lung carcinoma 43 | 413
Mammary Neoplasms 42 | 410
Waldenstrons macroglobulinemia 42 | 765
mucosa-associated lymphoid tissue lymphoma 42 | 480
Atherosclerosis 41 | 275
Vascular disease 41 | 281
Adenoma 40 | 165
Bipolar Disorder 40 | 266
Cerebrovascular disease 40 | 231
hepatocellular carcinoma 40 | 532
Pain 39 | 70
Prostatic Neoplasms 39 | 471
dermatomyositis 39 | 933
nasopharyngeal carcinoma 38 | 1,056
Endometriosis 37 | 535
Hyperalgesia 37 | 71
pancreatic carcinoma 37 | 567
Cocaine-Related Disorders 36 | 88
Heart disease 36 | 279
Pain agnosia 36 | 99
Intellectual disability 35 | 573
Arthritis 34 | 248
Migraine 34 | 79
Osteoporosis 34 | 257
Alcohol dependence 33 | 107
Crohn's disease 33 | 304
aldosterone-producing adenoma 33 | 664
acute quadriplegic myopathy 31 | 1,157

Tissue

Female tissues 1,209 | 18,647
Urinary Tract 1,179 | 18,444
Nervous System 1,129 | 18,561
Endocrine System 1,126 | 18,512
Digestive Tract 1,098 | 18,473
Skin and soft tissues 1,055 | 18,115
Liver and Pancreas 989 | 18,136
Blood and immune system 964 | 17,995
Cardiovascular System 956 | 17,958
Male tissues 921 | 17,969
Respiratory system 892 | 17,484

Target Family

oGPCR 416 | 421
Non-IDG 376 | 11,971
GPCR 299 | 406
Enzyme 154 | 4,146
Kinase 73 | 634
Ion Channel 11 | 341
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by GPCR 1,330 | 1,330
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401