Development Level

Tbio 467 | 10,625
Tdark 451 | 7,003
Tchem 252 | 1,890
Tclin 159 | 602

Collection

GPCR: IDG Consortium (Targets) 64 | 127
GPCR: IDG Consortium (Complete/Control) 12 | 26
Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

preweaning lethality, complete... 30 | 633
decreased body weight 16 | 174
decreased lean body mass 15 | 195
decreased bone mineral content 14 | 157
abnormal behavior 13 | 226
abnormal bone structure 13 | 131
preweaning lethality, incomple... 13 | 260
decreased grip strength 10 | 123
decreased total body fat amoun... 9 | 186
decreased circulating alanine ... 8 | 53
decreased circulating choleste... 8 | 85
enlarged heart 8 | 111
abnormal bone mineralization 7 | 55
decreased bone mineral density 7 | 126
decreased circulating HDL chol... 7 | 77
decreased circulating triglyce... 7 | 83
embryonic lethality prior to t... 7 | 187
male infertility 7 | 62
decreased circulating glucose ... 6 | 121
improved glucose tolerance 6 | 56
increased circulating HDL chol... 6 | 63
increased circulating alkaline... 6 | 119
increased total body fat amoun... 6 | 57
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
abnormal retinal pigmentation 5 | 61
decreased body length 5 | 108
decreased circulating LDL chol... 5 | 37
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
hypoactivity 5 | 89
increased heart weight 5 | 37
abnormal coat-hair pigmentatio... 4 | 54
abnormal epididymis morphology 4 | 31
abnormal seminal vesicle morph... 4 | 47
decreased caudal vertebrae num... 4 | 49
decreased circulating insulin ... 4 | 75
decreased fasted circulating g... 4 | 49
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
increased blood urea nitrogen ... 4 | 44
increased circulating calcium ... 4 | 32
increased circulating sodium l... 4 | 71
increased grip strength 4 | 83
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal kidney morphology 3 | 30
abnormal lens morphology 3 | 73
cataract 3 | 26
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased circulating calcium ... 3 | 33
decreased circulating chloride... 3 | 32
decreased circulating creatini... 3 | 31
decreased circulating serum al... 3 | 79
decreased circulating sodium l... 3 | 18
decreased circulating total pr... 3 | 41
decreased hemoglobin content 3 | 53
decreased kidney weight 3 | 7
decreased neutrophil cell numb... 3 | 37
decreased vertical activity 3 | 22
enlarged epididymis 3 | 27
hydrops fetalis 3 | 22
hyperactivity 3 | 108
impaired pupillary reflex 3 | 14
impaired righting response 3 | 19
increased bone mineral content 3 | 92
increased circulating creatini... 3 | 29
increased circulating phosphat... 3 | 24
increased circulating total pr... 3 | 20
increased fasted circulating g... 3 | 68
increased hemoglobin content 3 | 45
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased monocyte cell number 3 | 27
increased or absent threshold ... 3 | 128
increased startle reflex 3 | 38
limb grasping 3 | 35
short tibia 3 | 82
tremors 3 | 34
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal spleen morphology 2 | 36
abnormal vibrissa morphology 2 | 17
cardiovascular system phenotyp... 2 | 35
decreased IgE level 2 | 3
decreased circulating bilirubi... 2 | 14
decreased rib number 2 | 59
impaired glucose tolerance 2 | 52
increased body length 2 | 20
increased body weight 2 | 42
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
small testis 2 | 37
vertebral fusion 2 | 23

Disease

osteosarcoma 412 | 7,933
ovarian cancer 391 | 8,491
psoriasis 387 | 6,685
medulloblastoma, large-cell 364 | 6,234
glioblastoma 316 | 5,572
Cancer 251 | 2,346
lung cancer 251 | 4,473
atypical teratoid / rhabdoid tumor 246 | 4,369
pilocytic astrocytoma 221 | 3,086
lung carcinoma 195 | 2,844
oligodendroglioma 189 | 2,849
diabetes mellitus 186 | 1,663
malignant mesothelioma 183 | 3,163
invasive ductal carcinoma 182 | 2,950
interstitial cystitis 179 | 2,299
lung adenocarcinoma 179 | 2,714
primitive neuroectodermal tumor 176 | 3,031
Breast cancer 171 | 3,098
ependymoma 162 | 2,514
pediatric high grade glioma 161 | 2,712
ulcerative colitis 161 | 2,087
Carcinoma 159 | 2,147
non-small cell lung cancer 156 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 148 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 145 | 2,988
astrocytic glioma 143 | 2,241
subependymal giant cell astrocytoma 143 | 2,287
adult high grade glioma 135 | 2,148
pancreatic cancer 131 | 2,300
pituitary cancer 112 | 1,972
ductal carcinoma in situ 110 | 1,745
breast carcinoma 108 | 1,614
tuberculosis 106 | 1,563
Pick disease 105 | 1,893
cystic fibrosis 105 | 1,670
medulloblastoma 105 | 1,524
colon cancer 104 | 1,475
Obesity 102 | 616
group 4 medulloblastoma 102 | 1,875
astrocytoma 100 | 1,493
Schizophrenia 95 | 503
group 3 medulloblastoma 94 | 2,254
posterior fossa group A ependymoma 86 | 1,511
Rheumatoid Arthritis 84 | 1,170
cutaneous lupus erythematosus 80 | 1,056
posterior fossa group B ependymoma 75 | 1,530
Asthma 73 | 349
Parkinson's disease 68 | 364
Multiple myeloma 67 | 1,327
adrenocortical carcinoma 64 | 1,427
atypical teratoid/rhabdoid tumor 64 | 1,095
sonic hedgehog group medulloblastoma 64 | 1,482
primary pancreatic ductal adenocarcinoma 63 | 1,271
primary Sjogren syndrome 60 | 788
Hypertension 56 | 293
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,795
gastric carcinoma 51 | 832
Multiple Sclerosis 50 | 498
juvenile dermatomyositis 50 | 1,189
Alzheimer's disease 48 | 644
Autistic Disorder 47 | 320
Kidney disease 47 | 397
non primary Sjogren syndrome sicca 47 | 840
active Crohn's disease 46 | 918
esophageal adenocarcinoma 45 | 737
fibroadenoma 45 | 557
spina bifida 45 | 1,064
Epilepsy 44 | 346
Hypertensive disease 44 | 193
Atopic dermatitis 43 | 944
Down syndrome 43 | 548
hepatocellular carcinoma 43 | 550
non-small cell lung carcinoma 43 | 413
Mammary Neoplasms 42 | 410
mucosa-associated lymphoid tissue lymphoma 42 | 480
Atherosclerosis 41 | 275
Vascular disease 41 | 281
Waldenstrons macroglobulinemia 41 | 764
Adenoma 40 | 165
Bipolar Disorder 40 | 266
Cerebrovascular disease 40 | 231
Pain 39 | 70
Prostatic Neoplasms 39 | 471
dermatomyositis 38 | 966
nasopharyngeal carcinoma 38 | 1,056
Endometriosis 37 | 535
Hyperalgesia 37 | 71
pancreatic carcinoma 37 | 567
Cocaine-Related Disorders 36 | 88
Heart disease 36 | 279
Pain agnosia 36 | 99
Intellectual disability 35 | 573
Arthritis 34 | 248
Migraine 34 | 79
Osteoporosis 34 | 259
Alcohol dependence 33 | 107
Crohn's disease 33 | 304
Polycystic Ovary Syndrome 33 | 334
aldosterone-producing adenoma 33 | 664

Tissue

Female tissues 1,208 | 18,646
Urinary Tract 1,178 | 18,443
Nervous System 1,128 | 18,560
Endocrine System 1,125 | 18,511
Digestive Tract 1,097 | 18,472
Skin and soft tissues 1,054 | 18,114
Liver and Pancreas 988 | 18,135
Blood and immune system 963 | 17,994
Cardiovascular System 955 | 17,957
Male tissues 920 | 17,968
Respiratory system 891 | 17,483

Target Family

oGPCR 416 | 421
Non-IDG 376 | 11,969
GPCR 299 | 408
Enzyme 153 | 4,146
Kinase 73 | 634
Ion Channel 11 | 341
Transcription Factor 1 | 1,400

Reactome Pathway

Signaling by GPCR 1,329 | 1,329
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.51625 341.8 227
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Rho guanine nucleotide exchange factor 25 ARHGEF25 Tbio Non-IDG -1.42716 30.4 46
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.72902 59.1 216
Motilin receptor MLNR Tchem GPCR -2.15968 125.5 135
Gonadotropin-releasing hormone receptor GNRHR Tclin GPCR -2.61137 425.1 280