Development Level

Tbio 31 | 10,625
Tchem 10 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 4 | 187
decreased kidney weight 3 | 7
abnormal embryo size 2 | 112
decreased bone mineral content 2 | 157
impaired pupillary reflex 2 | 14
abnormal body wall morphology 1 | 7
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal motor learning 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal tail morphology 1 | 17
absent startle reflex 1 | 15
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased circulating sodium l... 1 | 18
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating free fat... 1 | 17
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1

Disease

ovarian cancer 22 | 8,484
lung cancer 20 | 4,466
Cancer 18 | 2,346
osteosarcoma 18 | 7,933
psoriasis 15 | 6,685
Breast cancer 11 | 3,094
group 3 medulloblastoma 10 | 2,254
medulloblastoma, large-cell 10 | 6,234
Carcinoma 9 | 2,147
invasive ductal carcinoma 9 | 2,950
non-small cell lung cancer 9 | 2,798
atypical teratoid / rhabdoid tumor 8 | 4,369
breast carcinoma 8 | 1,614
glioblastoma 8 | 5,572
lung adenocarcinoma 8 | 2,713
Cleft Lip 7 | 91
Cleft palate 7 | 125
Mammary Neoplasms 7 | 410
diabetes mellitus 7 | 1,663
malignant mesothelioma 7 | 3,162
LADD syndrome 5 | 9
Liver Cirrhosis 5 | 101
Liver carcinoma 5 | 217
Lung Neoplasms 5 | 171
Multiple myeloma 5 | 1,327
Noonan Syndrome 5 | 33
Parkinson's disease 5 | 364
astrocytoma 5 | 1,493
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 2,514
juvenile dermatomyositis 5 | 1,189
lung carcinoma 5 | 2,844
oligodendroglioma 5 | 2,849
pancreatic cancer 5 | 2,300
pediatric high grade glioma 5 | 2,712
Achondroplasia 4 | 20
Adenoma 4 | 165
Craniosynostosis 4 | 47
Down syndrome 4 | 548
Endometrial cancer 4 | 25
Kidney cancer 4 | 118
Rheumatoid Arthritis 4 | 1,160
Stomach Neoplasms 4 | 282
colon cancer 4 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
pilocytic astrocytoma 4 | 3,086
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
Acrocephalosyndactylia 3 | 15
Adenocarcinoma 3 | 115
Adenoid Cystic Carcinoma 3 | 99
Cardiofaciocutaneous syndrome 3 | 15
Colorectal Neoplasms 3 | 217
Connective tissue cancer 3 | 9
Craniofacial Abnormalities 3 | 147
Heart disease 3 | 279
Hemangiosarcoma 3 | 18
Hypospadias 3 | 65
Intellectual disability 3 | 573
Mouth Neoplasms 3 | 42
NEVUS, EPIDERMAL (disorder) 3 | 4
Neoplasms, Experimental 3 | 33
Neuroblastoma 3 | 78
Papillary thyroid carcinoma 3 | 37
Penile Neoplasms 3 | 4
Prostatic Neoplasms 3 | 471
Pulmonary Fibrosis 3 | 66
Squamous cell carcinoma 3 | 94
Synostosis 3 | 18
Thyroid cancer 3 | 25
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
interstitial cystitis 3 | 2,299
medulloblastoma 3 | 1,524
nasopharyngeal carcinoma 3 | 1,056
non primary Sjogren syndrome sicca 3 | 840
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
primitive neuroectodermal tumor 3 | 3,031
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Cholesteatoma 2 | 13
Cockayne syndrome 2 | 54
Disease Progression 2 | 125
Endometrial carcinoma 2 | 18
Exanthem 2 | 39
Gout 2 | 93
IGA Glomerulonephritis 2 | 454
Liver neoplasms 2 | 109
Lung disease 2 | 132
Malignant neoplasm of breast 2 | 63
Mesothelioma 2 | 40
Reperfusion Injury 2 | 84
atypical teratoid/rhabdoid tumor 2 | 1,095
tuberculosis 2 | 1,557
type II diabetes mellitus and post-ischemic heart failure 2 | 89

Tissue

Endocrine System 43 | 18,512
Female tissues 43 | 18,647
Nervous System 43 | 18,561
Skin and soft tissues 43 | 18,115
Blood and immune system 42 | 17,995
Cardiovascular System 42 | 17,958
Digestive Tract 42 | 18,473
Liver and Pancreas 42 | 18,136
Urinary Tract 42 | 18,444
Male tissues 41 | 17,969
Respiratory system 38 | 17,484

Target Family

Non-IDG 24 | 11,971
Enzyme 16 | 4,146
Kinase 3 | 634

Reactome Pathway

Signaling by FGFR2 in disease 43 | 43
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271
General transcription factor IIF subunit 2 GTF2F2 Tbio Non-IDG -1.54703 35.9 153
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.97848 10115.4 658
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
DNA-directed RNA polymerase II subunit RPB4 POLR2D Tdark Enzyme -0.50937 3.13 114
General transcription factor IIF subunit 1 GTF2F1 Tbio Non-IDG -1.59692 42.8 148